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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2024.6.MIM.1</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-1031</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Медицинская визуализация</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Medical Imaging</subject></subj-group></article-categories><title-group><article-title>Динамическая контрастная магнитнорезонансная перфузия головного мозга у детей с краниосиностозами</article-title><trans-title-group xml:lang="en"><trans-title>Dynamic contrast-enhanced magnetic resonance perfusion of the brain in children with craniosynostosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5008-954X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лукин Максим Владимирович, Аспирант кафедры лучевой диагностики и медицинской визуализации с клиникой ИМО </p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Maksim V. Lukin, Postgraduate student of the Department of Radiation Diagnostics and Medical Imaging with the Clinic at the Institute of Medical Education </p><p>2, Akkuratov St., St. Petersburg, 197341</p></bio><email xlink:type="simple">lukin.mv.radiology@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-0778-6396</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филин</surname><given-names>Я. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Filin</surname><given-names>Ya. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филин Яна Альбертовна, Ординатор кафедры лучевой диагностики и медицинской визуализации с клиникой ИМО </p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Yana A. Filin, Resident of the Department of Radiation Diagnostics and Medical Imaging with the Clinic at the Institute of Medical Education </p><p>2, Akkuratov St., St. Petersburg, 197341</p></bio><email xlink:type="simple">filin_yana@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-4731-5250</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Звездин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zvezdin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Звездин Антон Викторович, Студент 6 курса педиатрического факультета </p><p>Литовская ул., 2, г. Санкт-Петербург, 194100</p></bio><bio xml:lang="en"><p>Anton V. Zvezdin, 6th year student of the pediatric faculty </p><p>2, Litovskaya St., St. Petersburg, 194100</p></bio><email xlink:type="simple">antonzvezdin@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-7964-7857</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Береговский</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Beregovskiy</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Береговский Даниил Андреевич, Ординатор кафедры лучевой диагностики и медицинской визуализации с клиникой ИМО </p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Daniil A. Beregovskiy, Resident of the Department of Radiation Diagnostics and Medical Imaging with the Clinic at the Institute of Medical Education </p><p>2, Akkuratov St., St. Petersburg, 197341</p></bio><email xlink:type="simple">bereg.daniil96@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2249-1405</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефимцев</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Efimtsev</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефимцев Александр Юрьевич, Д-р мед. наук, доцент кафедры лучевой диагностики и медицинской визуализации с клиникой ИМО </p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Aleksandr Yu. Efimtsev, Dr. Sci. (Med.), Associate Professor of the Department of Radiation Diagnostics and Medical Imaging with the Clinic at the Institute of Medical Education </p><p>2, Akkuratov St., St. Petersburg, 197341</p></bio><email xlink:type="simple">atralf@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1611-5000</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Труфанов</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Trufanov</surname><given-names>G. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Труфанов Геннадий Евгеньевич, Д-р мед. наук, профессор, заведующий кафедрой лучевой диагностики и медицинской визуализации с клиникой ИМО </p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Gennadiy E. Trufanov, Dr. Sci. (Med.), Professor, Head of the Department of Radiation Diagnostics and Medical Imaging with the Clinic at the Institute of Medical Education </p><p>2, Akkuratov St., St. Petersburg, 197341</p></bio><email xlink:type="simple">trufanovge@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Национальный медицинский исследовательский центр имени В.А. Алмазова<country>Россия</country></aff><aff xml:lang="en">Almazov National Medical Research Center<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Санкт-Петербургский государственный педиатрический медицинский университет<country>Россия</country></aff><aff xml:lang="en">Saint-Petersburg State Pediatric Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2024</year></pub-date><volume>14</volume><issue>6</issue><fpage>151</fpage><lpage>158</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лукин М.В., Филин Я.А., Звездин А.В., Береговский Д.А., Ефимцев А.Ю., Труфанов Г.Е., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Лукин М.В., Филин Я.А., Звездин А.В., Береговский Д.А., Ефимцев А.Ю., Труфанов Г.Е.</copyright-holder><copyright-holder xml:lang="en">Lukin M.V., Filin Y.A., Zvezdin A.V., Beregovskiy D.A., Efimtsev A.Y., Trufanov G.E.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/1031">https://vestnik.reaviz.ru/jour/article/view/1031</self-uri><abstract><p>Краниосиностоз – раннее закрытие швов черепа, что приводит к его деформации, краниоцеребральной диспропорции и может повлечь развитие внутричерепной гипертензии, стойких неврологических и когнитивных нарушений. Магнитно-резонансная томография, дополненная контрастной динамической МР-перфузией, позволяет детально оценить интракардиальные структуры, а также оценить показатели мозгового кровотока в зонах предполагаемой компрессии головного мозга у детей с краниосиностозами. Цель исследования: оценить показатели мозгового кровотока (CBV и CBF) у детей с краниосиностозами с помощью контрастной динамической МР-перфузии на дооперационном этапе. Объект и методы. Было обследовано 48 детей с различными видами краниосиностоза: у 10 (20 %) детей отмечался синостоз сагиттального шва, у 15 (31 %) – метопического шва, у 9 (19%) – коронарного шва с одной стороны, у 6 (13 %) – бикоронарный синостоз, у 2 (4 %) – лямбдовидный синостоз и у 6 (13 %) – поражение всех швов. Построение цветных перфузионных карт CBF и СBV осуществлялось с помощью системы syngo.via (Siemens). Результаты. По данным МР-перфузии при метопическом краниосиностозе в зонах компрессии (лобные доли) относительные показатели rCBV и rCBF составили 88,3 ± 24,6 % и 85,5 ± 19,6 % соответственно относительно теменно-затылочных областей. При монокоронарном синостозе в зоне компрессии (ипсилатеральная лобная доля) относительно контрлатеральной лобной доли равны 95,3 ± 3,1 % (rCBV) и 93,1 ± 2,2 %, (rCBF), а относительно затылочных долей – 84,4 ± 5,2 % (rCBV) и 87,3 ± 8,2 % (rCBF); при бикоронарном синостозе в лобных долях равны 86,2 ± 19,7 % (rCBV) и 86,4 ± 14,7 % (rCBF) относительно теменно-затылочных областей; при заращении сагиттального шва, в теменных долях относительно лобных и затылочных долей составили 99,1 ± 3,2 % (rCBV) и 98,1 ± 2,4 % (rCBF).</p></abstract><trans-abstract xml:lang="en"><p>Craniosynostosis is the premature closure of cranial sutures, leading to skull deformation, cranio-cerebral disproportion, and potentially resulting in the development of intracranial hypertension, persistent neurological, and cognitive impairments. Magnetic resonance imaging (MRI) complemented by dynamic contrast-enhanced MR perfusion, allows for a detailed assessment of intracardiac structures, as well as evaluation of cerebral blood flow parameters in areas of suspected brain compression in children with craniosynostosis. Purpose of the study: еvaluate cerebral blood flow parameters (CBV and CBF) in children with craniosynostosis using contrast-enhanced dynamic MR perfusion in the preoperative stage. Object and methods. Forty-eight children with various types of craniosynostosis were examined: 10 (20%) had sagittal suture synostosis, 15 (31%) had metopic suture synostosis, 9 (19%) had unilateral coronal suture synostosis, 6 (13%) had bicoronal synostosis, 2 (4%) had lambdoid synostosis, and 6 (13%) had involvement of all sutures. Color perfusion maps of CBF and CBV were constructed using the syngo.via system (Siemens). Results. According to MR perfusion data, in areas of compression (frontal lobes) relative rCBV and rCBF indices in metopic craniosynostosis were 88.3 ± 24.6% and 85.5 ± 19.6% respectively, compared to the occipito-parietal regions. In cases of unilateral coronal synostosis, in the compression zone (ipsilateral frontal lobe) relative to the contralateral frontal lobe, they were 95.3 ± 3.1% (rCBV) and 93.1 ± 2.2% (rCBF), and relative to the occipital lobes, 84.4 ± 5.2% (rCBV) and 87.3 ± 8.2% (rCBF). In cases of bicoronal synostosis, in the frontal lobes they were 86.2 ± 19.7% (rCBV) and 86.4 ± 14.7% (rCBF) relative to the occipito-parietal regions. In cases of sagittal suture closure, in the temporal lobes relative to the frontal and occipital lobes, they were 99.1 ± 3.2% (rCBV) and 98.1±2.4% (rCBF).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>краниосиностоз</kwd><kwd>магнитно-резонансная томография</kwd><kwd>динамическая контрастная МР-перфузия</kwd><kwd>краниоцеребральная диспропорция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>craniosynostosis</kwd><kwd>MRI</kwd><kwd>dynamic contrast-enhanced MR perfusion</kwd><kwd>craniocerebral disproportion</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kim HJ, Roh HG, Lee IW. Craniosynostosis: Updates in Radiologic Diagnosis. J Korean Neurosurg Soc. 2016 May;59(3):219-226. https://doi.org/10.3340/jkns.2016.59.3.219. Epub 2016 May 10. PMID: 27226852; PMCID: PMC4877543.</mixed-citation><mixed-citation xml:lang="en">Kim HJ, Roh HG, Lee IW. 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