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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2024.4.CASE.3</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-1057</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical case</subject></subj-group></article-categories><title-group><article-title>Сложности диагностики и лечения медуллярного рака щитовидной железы. Клиническое наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Complexities in diagnosis and treatment of medullary thyroid cancer. Clinical observation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5489-9352</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фролова Елена Владимировна, кафедра факультетской хирургии</p><p>ул. Чапаевская, д. 89, г. Самара, 443099</p></bio><bio xml:lang="en"><p>Elena V. Frolova, Department of Faculty Surgery</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">frolova-samsmu2009@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-5605-1372</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наумова Наталья Николаевна</p><p>бульвар Здоровья, д. 25, г. Тольятти, 44503</p></bio><bio xml:lang="en"><p>Natal'ya N. Naumova</p><p>25 Health Boulevard, Togliatti, 445039</p></bio><email xlink:type="simple">N.Naunova83@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7452-1030</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салаутин</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Salautin</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Салаутин Евгений Владимирович, кафедра факультетской хирургии</p><p>ул. Чапаевская, д. 89, г. Самара, 443099</p></bio><bio xml:lang="en"><p>Evgeniy V. Salautin, Department of Faculty Surgery</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">salautin163@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-8051-3264</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Володина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Volodina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Володина Екатерина Алексеевна, кафедра факультетской хирургии</p><p>ул. Чапаевская, д. 89, г. Самара, 443099</p></bio><bio xml:lang="en"><p>Ekaterina A. Volodina, Department of Faculty Surgery</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">volodinak@vk.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тольяттинская городская больница №5</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Togliatti City Clinical Hospital No. 5</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>08</day><month>09</month><year>2024</year></pub-date><volume>14</volume><issue>4</issue><fpage>99</fpage><lpage>105</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фролова Е.В., Наумова Н.Н., Салаутин Е.В., Володина Е.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Фролова Е.В., Наумова Н.Н., Салаутин Е.В., Володина Е.А.</copyright-holder><copyright-holder xml:lang="en">Frolova E.V., Naumova N.N., Salautin E.V., Volodina E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/1057">https://vestnik.reaviz.ru/jour/article/view/1057</self-uri><abstract><p>В данной статье рассматриваются этиология спорадической и наследственной формы медуллярного рака щитовидной железы (МРЩЖ), диагностические критерии, позволяющие наиболее точно и чётко поставить диагноз и дифференцировать его от схожих по симптоматике состояний, морфологические изменения при медуллярном раке щитовидной железы. Данная форма рака щитовидной железы является одной из наименее изученных в связи с особенностями гистогенетического генеза и невысокой частотой обращения населения с этой проблемой. Медуллярный рак щитовидной железы часто диагностируется в момент плановой госпитализации пациентов по проблемам в смежной области, напрямую не связанным с онкологией щитовидной железы. Представленное клиническое наблюдение отражает сложность лечения пациента с медуллярным раком щитовидной железы, обусловленное его продолжительностью, а также неоднократными оперативными вмешательствами, которые были направлены на удаление множественных метастазов. Данная статья демонстрирует необходимость своевременной ранней диагностики в рамках диспансеризации населения и повышенной онконастороженности в выявлении медуллярного рака щитовидной железы.</p></abstract><trans-abstract xml:lang="en"><p>This article discusses the etiology of sporadic and hereditary forms of medullary thyroid cancer (MTC), diagnostic criteria that allow the most accurate and accurate diagnosis and differentiate it from similar symptoms, morphological changes in MTC, which is one of the least studied due to the peculiarities of its histogenetic genesis and low frequency of treatment of the population with this a problem. MTC is often diagnosed at the time of planned hospitalization of patients for problems in a related area, but not directly related to thyroid cancer. In this article, clinical manifestations presented in a specific clinical case are investigated, markers of immunohistochemical studies are determined. This case is interesting and unusual for the duration of the patient's treatment, as well as successful surgical interventions that were aimed at removing multiple metastases. To date, the number of referrals from patients with minimal structural and functional changes in the thyroid gland is small, which indicates that the disease is often diagnosed at a later date. In the minds of a certain percentage of the population, the idea of a possible self-healing of the body is firmly fixed, which is often decisive with the progression of the disease (especially with a sharp jump in progress, for example, after a general somatic decrease in the immune response after infectious diseases, hypothermia, radiation exposure). This article is indicative in this matter – it clearly demonstrates the need for timely vigilance and care for the body, timely medical examination of the population and attentive attitude in particular to the thyroid gland.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>медуллярный рак щитовидной железы</kwd><kwd>гистологические изменения</kwd><kwd>морфология</kwd><kwd>клинические проявления</kwd><kwd>метастазирование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>medullary thyroid cancer</kwd><kwd>histological changes</kwd><kwd>morphology</kwd><kwd>clinical manifestations</kwd><kwd>metastases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Caillé S, Debreuve-Theresette A, Vitellius G, Deguelte S, La Manna L, Zalzali M. Medullary Thyroid Cancer: Epidemiology and Characteristics According to Data From the Marne-Ardennes Register 1975-2018. 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