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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2025.1.CASE.4</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-1186</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>Холецистодуоденальный свищ, сопровождающийся кровотечением из верхних отделов желудочно-кишечного тракта (клинический случай)</article-title><trans-title-group xml:lang="en"><trans-title>Cholecystoduodenal fistula accompanied by bleeding from the upper gastrointestinal tract (clinical case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0854-8922</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мануйлов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Manuylov</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мануйлов Владимир Михайлович - д-р мед. наук, профессор, Заслуженный врач Российской Федерации, главный врач.</p><p>ул. Авиационная, д. 35, Пушкино, 141206</p></bio><bio xml:lang="en"><p>Vladimir M. Manuylov - Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Chief Physician of the Pushkin Clinical Hospital named after prof. V.P. Rozanov.</p><p>35, Aviatsionnaya str., Pushkino, 141206</p></bio><email xlink:type="simple">pushkino_rb@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2616-2940</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербюк</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shcherbyuk</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щербюк Александр Николаевич - д-р мед. наук, профессор, заведующий научно-клинического отдела, Пушкинская КБ им. проф. Розанова В.П., профессор кафедры хирургических болезней, Московский медицинский университета «Реавиз».</p><p>ул. Авиационная, д. 35, г. Пушкино, 141206; Краснобогатырская ул., д. 2, стр. 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Aleksandr N. Shcherbyuk - Dr. Sci. (Med.), Professor, Head of the Scientific and Clinical Department, Pushkin Clinical Hospital named after prof. V.P. Rozanov, Professor of the Department of Surgical Diseases, Moscow Medical University "Reaviz".</p><p>35, Aviatsionnaya str., Pushkino, 141206; 2, Krasnobogatyrskaya str., building 2, Moscow, 107564</p></bio><email xlink:type="simple">ANS1949@Rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-3464-3328</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Царёв</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsarev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Царёв Даниил Александрович - врач-колопроктолог, хирург, стационар № 2.</p><p>ул. Авиационная, д. 35, Пушкино, 141206</p></bio><bio xml:lang="en"><p>Daniil A. Tsarev - Proctologist, surgeon, hospital #2, Pushkin Clinical Hospital named after prof. V.N. Rozanov.</p><p>35, Aviatsionnaya str., Pushkino, 141206</p></bio><email xlink:type="simple">tsaryov@kkmx.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2546-2362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захаров</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharov</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Захаров Юрий Иванович - канд. мед. наук, врач-хирург, старший научный сотрудник отделения абдоминальной хирургии.</p><p>ул. Щепкина, д. 61/2, Москва, 129110</p></bio><bio xml:lang="en"><p>Yuriy I. Zakharov - Cand. Sci. (Med.), surgeon, senior researcher, abdominal surgery department, Moscow Regional Research Clinical Institute named after M.F. Vladimirsky.</p><p>61/2, Shchepkina str., Moscow, 129110</p></bio><email xlink:type="simple">zakharov-69@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8784-7655</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Немсцверидзе</surname><given-names>Я. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Nemstsveridze</surname><given-names>Ya. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Немсцверидзе Яков Элгуджович - специалист научно-инновационного отдела, Московский медицинский университет «Реавиз»; врач-стоматолог, врач-клинический ординатор кафедры ортопедической стоматологии, МОНИКИ им. М.Ф. Владимирского.</p><p>Краснобогатырская ул., д. 2, стр. 2, Москва, 107564; ул. Щепкина, д. 61/2, г. Москва, 129110</p></bio><bio xml:lang="en"><p>Yakov E. Nemstsveridze - Specialist of the Research and Innovation Department, Moscow Medical University "Reaviz"; dentist, resident physician of the Department of Orthopedic Dentistry, Moscow Regional Research Clinical Institute named after M.F. Vladimirsky.</p><p>2, Krasnobogatyrskaya str., building 2, Moscow, 107564; 61/2, Shchepkina str., Moscow, 129110</p></bio><email xlink:type="simple">9187751@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0506-5677</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мохов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mokhov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мохов Андрей Витальевич - канд. мед. наук, заведующий хирургическим отделением, стационар № 2.</p><p>ул. Авиационная, д. 35, Пушкино, 141206</p></bio><bio xml:lang="en"><p>Andrey V. Mokhov - Cand. Sci. (Med.), Head of the Surgical Department, Hospital No. 2, Pushkin Clinical Hospital named after prof. V.N. Rozanov.</p><p>35, Aviatsionnaya str., Pushkino, 141206</p></bio><email xlink:type="simple">mkhvand@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8320-8813</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мохов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mokhov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мохов Дмитрий Андреевич - врач-хирург, стационар № 2.</p><p>ул. Авиационная, д. 35, Пушкино, 141206</p></bio><bio xml:lang="en"><p>Dmitriy A. Mokhov - Surgeon, Hospital No. 2, Pushkin Clinical Hospital named after prof. V.N. Rozanov.</p><p>35, Aviatsionnaya str., Pushkino, 141206</p></bio><email xlink:type="simple">Mokhovdmitriy@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-2886-1047</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Набиева</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nabieva</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Набиева Елена Юрьевна - студентка 4 курса лечебного дела.</p><p>ул. Трубецкая, д. 8, стр. 2, Москва, 119048</p></bio><bio xml:lang="en"><p>Elena Yu. Nabieva - 4th year student of General Medicine, First Moscow State Medical University named after I. M. Sechenov (Sechenov University).</p><p>8 Trubetskaya str., Bldg. 2, Moscow, 119048</p></bio><email xlink:type="simple">lena.nabieva.03@bk.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-2138-0225</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпина</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpina</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпина София Сергеевна - студентка 2 курса лечебного дела.</p><p>ул. Трубецкая, д. 8, стр. 2, Москва, 119048</p></bio><bio xml:lang="en"><p>Sofiya S. Karpina - 2nd year student of General Medicine, First Moscow State Medical University named after I.M. Sechenov (Sechenov University).</p><p>8 Trubetskaya str., Bldg. 2, Moscow, 119048</p></bio><email xlink:type="simple">skarpina93@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0445-4053</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гафаров</surname><given-names>У. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Gafarov</surname><given-names>U. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гафаров Умеджон Олимджонович - канд. мед. наук, врач-хирург, Пушкинская КБ им. проф. Розанова В.Н.; МНПЦ борьбы с туберкулезом.</p><p>ул. Авиационная, д. 35, г. Пушкино, 141206; ул. Стромынка, д. 10, Москва, 107014</p></bio><bio xml:lang="en"><p>Umedzhon O. Gafarov - Cand. Sci. (Med.), Surgeon, Pushkin Clinical Hospital named after prof. V.N. Rozanov; Moscow City Scientific and Practical Center for the Fight against Tuberculosis.</p><p>35, Aviatsionnaya str., Pushkino, 141206; 10, Stromynka str., Moscow, 107014</p></bio><email xlink:type="simple">umed_78@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-9446-9204</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перетечиков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Peretechikov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Перетечиков Александр Владимирович - канд. мед. наук, заместитель главного врача по хирургии, врач-хирург, стационар №2.</p><p>ул. Авиационная, д. 35, Пушкино, 141206</p></bio><bio xml:lang="en"><p>Aleksandr V. Peretechikov - Cand. Sci. (Med.), Deputy Chief Physician for Surgery, Surgeon, Hospital No. 2, Pushkin Clinical Hospital named after prof. V.N. Rozanov.</p><p>35, Aviatsionnaya str., Pushkino, 141206</p></bio><email xlink:type="simple">pushkinomobsurg@mail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-2061-367X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юнкин</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Yunkin</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юнкин Антон Петрович - заведующий патологоанатомическим отделением, врач патологоанатом, стационар № 2.</p><p>ул. Авиационная, д. 35, Пушкино, 141206</p></bio><bio xml:lang="en"><p>Anton P. Yunkin - Head of the Pathological Anatomy Department, Pathologist, Hospital No. 2, Pushkin Clinical Hospital named after prof. V.N. Rozanov.</p><p>35, Aviatsionnaya str., Pushkino, 141206</p></bio><email xlink:type="simple">yunkin.tony@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пушкинская клиническая больница им. проф. Розанова В.Н.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pushkin Clinical Hospital named after prof. V.N. Rozanov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Пушкинская клиническая больница им. проф. Розанова В.Н.; Московский медицинский университет «Реавиз»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pushkin Clinical Hospital named after prof. V.N. Rozanov; Moscow Medical University "Reaviz"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research Clinical Institute named after M.F. Vladimirsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Московский медицинский университет «Реавиз»; Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Medical University "Reaviz"; Moscow Regional Research Clinical Institute named after M.F. Vladimirsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Пушкинская клиническая больница им. проф. Розанова В.Н.; Московский городской научно-практический центр борьбы с туберкулёзом</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pushkin Clinical Hospital named after prof. V.N. Rozanov; Moscow City Scientific and Practical Center for the Fight against Tuberculosis</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>20</day><month>03</month><year>2025</year></pub-date><volume>15</volume><issue>1</issue><fpage>123</fpage><lpage>129</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мануйлов В.М., Щербюк А.Н., Царёв Д.А., Захаров Ю.И., Немсцверидзе Я.Э., Мохов А.В., Мохов Д.А., Набиева Е.Ю., Карпина С.С., Гафаров У.О., Перетечиков А.В., Юнкин А.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Мануйлов В.М., Щербюк А.Н., Царёв Д.А., Захаров Ю.И., Немсцверидзе Я.Э., Мохов А.В., Мохов Д.А., Набиева Е.Ю., Карпина С.С., Гафаров У.О., Перетечиков А.В., Юнкин А.П.</copyright-holder><copyright-holder xml:lang="en">Manuylov V.M., Shcherbyuk A.N., Tsarev D.A., Zakharov Y.I., Nemstsveridze Y.E., Mokhov A.V., Mokhov D.A., Nabieva E.Y., Karpina S.S., Gafarov U.O., Peretechikov A.V., Yunkin A.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/1186">https://vestnik.reaviz.ru/jour/article/view/1186</self-uri><abstract><p>Введение. Холецистодуоденальный свищ является редким осложнением желчнокаменной болезни и исключительно редко проявляется массивным кровотечением из верхних отделов желудочно-кишечного тракта. В мировой литературе описано всего 15 подобных клинических случаев. Цель исследования: представить клинический случай билиодигестивного свища, осложнённого кровотечением из верхних отделов желудочно-кишечного тракта, и проанализировать особенности диагностики и лечения данной патологии. Материалы и методы. Описан клинический случай пациента 62 лет с желчнокаменной болезнью, осложнённой холецистодуоденальным свищом и массивным желудочно-кишечным кровотечением. Проведён анализ литературных данных с систематизацией 15 аналогичных случаев. Результаты. У пациента с известным анамнезом желчнокаменной болезни и билиодигестивного свища развилось массивное кровотечение из верхних отделов желудочно-кишечного тракта с развитием геморрагического шока. Эндоскопические исследования выявили фиксированный геморрагический сгусток и язву луковицы двенадцатиперстной кишки. Несмотря на проводимую консервативную терапию и эндоскопический гемостаз на 8-е сутки произошёл рецидив кровотечения, потребовавший экстренного хирургического вмешательства. Интраоперационно выявлены холецистодуоденальный и холецистотрансверзальный свищи с продолжающимся кровотечением. Выполнены резекция 2/3 желудка на выключенной по Ру петле, холецистэктомия и правосторонняя гемиколэктомия. Заключение. Холецистодуоденальный свищ, осложнённый кровотечением, требует хирургического лечения, поскольку значительное кровотечение из крупных артерий редко устраняется консервативным лечением или эндоскопическим гемостазом. Представленный случай является 16-м в мировой хирургической практике, что подчёркивает необходимость дальнейшего изучения данной патологии и разработки эффективных методов лечения.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Cholecystoduodenal fistula is a rare complication of cholelithiasis and extremely rarely manifests as massive bleeding from the upper gastrointestinal tract. Only 15 similar clinical cases have been described in the world literature. Objective: To present a clinical case of a biliodigestive fistula complicated by upper gastrointestinal bleeding, and to analyze the features of diagnosis and treatment of this pathology. Materials and methods. A clinical case of a 62-year-old patient with cholelithiasis complicated by cholecystoduodenal fistula and massive gastrointestinal bleeding is described. An analysis of literature data with systematization of 15 similar cases was conducted. Results. A patient with a known history of cholelithiasis and biliodigestive fistula developed massive bleeding from the upper gastrointestinal tract with hemorrhagic shock. Endoscopic examinations revealed a fixed hemorrhagic clot and a duodenal bulb ulcer. Despite conservative therapy and endoscopic hemostasis, on the 8th day, rebleeding occurred requiring emergency surgical intervention. Intraoperatively, cholecystoduodenal and cholecystotransverse fistulas with ongoing bleeding were identified. A 2/3 gastric resection with Roux-en-Y reconstruction, cholecystectomy, and right hemicolectomy were performed. Conclusion. Cholecystoduodenal fistula complicated by bleeding requires surgical treatment, as significant bleeding from large arteries is rarely eliminated by conservative treatment or endoscopic hemostasis. The presented case is the 16th in world surgical practice, which emphasizes the need for further study of this pathology and the development of effective treatment methods.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Холецистодуоденальный свищ [D005764</kwd><kwd>D004386]</kwd><kwd>Желчный пузырь [D005705]</kwd><kwd>Двенадцатиперстная кишка [D004386]</kwd><kwd>Кровотечение из верхних отделов ЖКТ [D006471</kwd><kwd>D005764]</kwd><kwd>Осложнения билиарной патологии [D001650</kwd><kwd>D006505]</kwd><kwd>Желчнокаменная болезнь [D003628]</kwd><kwd>Неопластический процесс [D009369]</kwd><kwd>Клинический случай [D002363]</kwd><kwd>Экстренная хирургия [D013514</kwd><kwd>D013851]</kwd><kwd>Гастродуоденоскопия [D013903</kwd><kwd>D004386]</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Cholecystoduodenal fistula [D005764</kwd><kwd>D004386]</kwd><kwd>Gallbladder [D005705]</kwd><kwd>Duodenum [D004386]</kwd><kwd>Upper gastrointestinal bleeding [D006471</kwd><kwd>D005764]</kwd><kwd>Biliary tract disease complications [D001650</kwd><kwd>D006505]</kwd><kwd>Cholelithiasis [D003628]</kwd><kwd>Neoplastic process [D009369]</kwd><kwd>Case report [D002363]</kwd><kwd>Emergency surgery [D013514</kwd><kwd>D013851]</kwd><kwd>Gastroduodenoscopy [D013903</kwd><kwd>D004386]</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Inal M, Oguz M, Aksungur E, Soyupak S, Börüban S, Akgül E. 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