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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2025.2.MIM.2</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-1207</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Медицинская визуализация</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Medical Imaging</subject></subj-group></article-categories><title-group><article-title>Оценка правожелудочково-артериального сопряжения у пациентов с хронической сердечной недостаточностью и лёгочной гипертензией</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of right ventricular-arterial coupling in chronic heart failure and pulmonary hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-4672-2779</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондрашова</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondrashova</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кондрашова Ксения Владимировна, Врач ультразвуковой диагностики, заведующая отделением ультразвуковой диагностики регионального сосудистого центра</p><p>ул. Вишневского, 1, г. Калуга, 248007</p></bio><bio xml:lang="en"><p>Kseniya V. Kondrashova, Ultrasound diagnostics doctor, head of the ultrasound diagnostics department of the regional vascular center</p><p>Vishnevsky St., 1, Kaluga, 248007</p></bio><email xlink:type="simple">xenijasv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбакова</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Rybakova</surname><given-names>M. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рыбакова Марина Константиновна, доктор медицинских наук, профессор кафедры ультразвуковой диагностики </p><p>ул. Баррикадная, д. 2/1, стр. 1, г. Москва, 125993</p></bio><bio xml:lang="en"><p>Marina K. Rybakova, Dr. Sci. (Med.), Professor of the Department of Ultrasound Diagnostics</p><p>2/1, Barrikadnaya str., building 1, Moscow, 125993</p></bio><email xlink:type="simple">xenijasv@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Калужская областная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kaluga Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>06</month><year>2025</year></pub-date><volume>15</volume><issue>2</issue><fpage>198</fpage><lpage>205</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кондрашова К.В., Рыбакова М.К., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кондрашова К.В., Рыбакова М.К.</copyright-holder><copyright-holder xml:lang="en">Kondrashova K.V., Rybakova M.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/1207">https://vestnik.reaviz.ru/jour/article/view/1207</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Нарушение функции правого желудочка играет важную роль в течении хронической сердечной недостаточности и её исходов. Систолическая функция правого желудочка тесно связана с постнагрузкой, поэтому очень важно оценивать правожелудочково-артериальное сопряжение.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: определить значения показателей правожелудочково-артериального сопряжения при трансторакальной эхокардиографии в норме и у пациентов с хронической сердечной недостаточностью и лёгочной гипертензией.</p></sec><sec><title>Объект и методы</title><p>Объект и методы. В исследование включен 41 пациент с хронической сердечной недостаточностью вследствие ишемической болезни сердца или дилятационной кардиомиопатии с признаками лёгочной гипертензии по данным трансторакальной эхокардиографии. Средний возраст составил 69,2 ± 10,1 года; из них 12 (29%) женщин и 29 (71%) мужчин. У 27 (65,9%) пациентов с хронической сердечной недостаточностью фракция выброса левого желудочка была в пределах нормы. Также в исследование включено 37 здоровых лиц, средний возраст которых составил 59 ± 12 лет. При эхокардиографическом исследовании оценивались показатели правожелудочково-артериального сопряжения, такие как отношение амплитуды движения латеральной части фиброзного кольца трикуспидального клапана (tricuspid annular plane systolic excursion – TAPSE), скорости движения латеральной части фиброзного кольца трикуспидального клапана в режиме тканевой импульсноволновой допплерографии (скорость пика s’), фракционного изменения площади (ФИП) правого желудочка, глобальной продольной систолической деформации (ГПСД) правого желудочка и продольной систолической деформации свободной стенки правого желудочка к систолическому давлению в лёгочной артерии (СДЛА).</p></sec><sec><title>Результаты</title><p>Результаты.  У пациентов с хронической сердечной недостаточностью и лёгочной гипертензией все показатели правожелудочково-артериального сопряжения достоверно отличались от контрольной группы (P &lt; 0,0001), вне зависимости от величины фракции выброса левого желудочка. При этом показатели правожелудочково-артериального сопряжения (ФИП/СДЛА, s ФК ТК/СДЛА, ГПСД ПЖ/СДЛА, ПСД СС ПЖ/СДЛА) продемонстрировали высокую чувствительность и специфичность в отношении выявления нарушения связи между правым желудочком и лёгочной артерией. Наибольшую информативность среди показателей правожелудочково-артериального сопряжения продемонстрировали ГПСД ПЖ/СДЛА и ПСД СС ПЖ/СДЛА. В контрольной группе отмечено снижение показателей правожелудочково-артериального сопряжения у лиц более старшего возраста. </p></sec><sec><title>Выводы</title><p>Выводы. Включение параметров правожелудочково-артериального сопряжения в исследование функции правого желудочка у пациентов с хронической сердечной недостаточностью и лёгочной гипертензией повышает выявляемость разобщения между правым желудочком и лёгочной артерией. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Rationale</title><p>Rationale. Right ventricular dysfunction plays an important role in the course of chronic heart failure and its outcomes. Right ventricular systolic function is closely related to afterload; therefore, it is important to assess right ventricular-arterial coupling.</p></sec><sec><title>Objective</title><p>Objective. To determine the values of right ventricular-arterial coupling (RVAC) parameters during transthoracic echocardiography in healthy subjects and in patients with chronic heart failure and pulmonary hypertension.</p></sec><sec><title>Material and methods</title><p>Material and methods. 41 patients with chronic heart failure due to coronary heart disease or dilated cardiomyopathy with signs of PH were examined. The average age of the patients was 69.2 ± 10.1 years; 12 women (29%), 29 men (71%). In 27 of patients with CHF and PH (65.9%), the left ventricular ejection fraction (LVEF) was within normal limits. Echocardiographic examination assessed various parameters of RVAC, such as the ratios of TAPSE (tricuspid annular plane systolic excursion), peak systolic tissue velocity of the lateral tricuspid annulus (S′), RVFAC (fractional area change), RVGLS, and RVFWLS to pulmonary artery systolic pressure (PASP).</p></sec><sec><title>Results</title><p>Results. In patients with chronic heart failure and pulmonary hypertension, all measures of RVAC were significantly different from the control group  (P &lt; 0.0001), regardless of the left ventricular ejection fraction value. All the indicators of RVAC demonstrated high sensitivity and specificity in relation to RV-arterial uncoupling. In the control group, there was a decrease in RVAC rates in older individuals. The most diagnostic accuracy among RVAC parameters was demonstrated by RVGLS/PASP and RVFWLS/PASP.</p></sec><sec><title>Conclusions</title><p>Conclusions. Application of RVAC parameters in the RV function assessment increases the detection of RV-arterial uncoupling in chronic heart failure and pulmonary hypertension. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>функциональная МРТ [D060277]</kwd><kwd>коннектом [D001921.535.791.785]</kwd><kwd>детский церебральный паралич [D002547]</kwd><kwd>нейрореабилитация [D009469]</kwd><kwd>коррекционные костюмы [D011862]</kwd><kwd>нейропластичность [D009474]</kwd><kwd>сети покоя головного мозга [D066127]</kwd><kwd>функциональная коннективность [D056948]</kwd></kwd-group><kwd-group xml:lang="en"><kwd>functional MRI [D060277]</kwd><kwd>connectome [D001921.535.791.785]</kwd><kwd>cerebral palsy [D002547]</kwd><kwd>neurorehabilitation [D009469]</kwd><kwd>corrective suits [D011862]</kwd><kwd>neuroplasticity [D009474]</kwd><kwd>resting state networks [D066127]</kwd><kwd>functional connectivity [D056948]</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Todaro MC, Carerj S, Zito C, Trifirò MP, Consolo G, Khandheria B. Echocardiographic evaluation of right ventricular-arterial coupling in pulmonary hypertension. Am J Cardiovasc Dis. 2020 Oct 15;10(4):272-283. PMID: 33224574; PMCID: PMC7675169.</mixed-citation><mixed-citation xml:lang="en">1 Todaro MC, Carerj S, Zito C, Trifirò MP, Consolo G, Khandheria B. Echocardiographic evaluation of right ventricular-arterial coupling in pulmonary hypertension. Am J Cardiovasc Dis. 2020 Oct 15;10(4):272-283. PMID: 33224574; PMCID: PMC7675169.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Thandavarayan R.A., Chitturi K.R., Guha A. Pathophysiology of acute and chronic right heart failure. Cardiol. Clin. 2020;38(2):149–160. https://doi.org/10.1016/j.ccl.2020.01.009</mixed-citation><mixed-citation xml:lang="en">2 Thandavarayan R.A., Chitturi K.R., Guha A. Pathophysiology of acute and chronic right heart failure. Cardiol. Clin. 2020;38(2):149–160. https://doi.org/10.1016/j.ccl.2020.01.009</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Мартынюк Т.В., Валиева З.С., Азизов В.А.-О., Барбараш О.Л., Веселова Т.Н., Галявич А.С. и др. Диагностика и лечение лёгочной гипертензии. Евразийский кардиологический журнал. 2020;1:78–124. URL: https://cyberleninka.ru/article/n/diagnostika-i-lechenie-lyogochnoy-gipertenzii (дата обращения: 08.10.2024).</mixed-citation><mixed-citation xml:lang="en">3 Chazova I.E., Martynyuk T.V., Valieva Z.S., Azizov V.A.-O., Barbarash O.L., Veselova T.N., Galyavich A.S. et al. Diagnosis and treatment of pulmonary hypertension. Eurasian Journal of Cardiology. 2020;1:78–124. (In Russ.). URL: https://cyberleninka.ru/article/n/diagnostika-i-lechenie-lyogochnoy-gipertenzii (дата обращения: 08.10.2024).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tello K, Wan J, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Mohajerani E, Seeger W, Herberg U, Sommer N, Gall H, Richter MJ. Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular- Arterial Coupling in Severe Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Sep;12(9):e009047. https://doi.org/10.1161/CIRCIMAGING.119.009047. Epub 2019 Sep 10. PMID: 31500448; PMCID: PMC7099862.</mixed-citation><mixed-citation xml:lang="en">4 Tello K, Wan J, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Mohajerani E, Seeger W, Herberg U, Sommer N, Gall H, Richter MJ. Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular- Arterial Coupling in Severe Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Sep;12(9):e009047. https://doi.org/10.1161/CIRCIMAGING.119.009047. Epub 2019 Sep 10. PMID: 31500448; PMCID: PMC7099862.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Guazzi M, Dixon D, Labate V, Beussink-Nelson L, Bandera F, Cuttica MJ, Shah SJ. RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction: Stratification of Clinical Phenotypes and Outcomes. JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt B):1211-1221. https://doi.org/10.1016/j.jcmg.2016.12.024. Epub 2017 Apr 12. PMID: 28412423.</mixed-citation><mixed-citation xml:lang="en">5 Guazzi M, Dixon D, Labate V, Beussink-Nelson L, Bandera F, Cuttica MJ, Shah SJ. RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction: Stratification of Clinical Phenotypes and Outcomes. JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt B):1211-1221. https://doi.org/10.1016/j.jcmg.2016.12.024. Epub 2017 Apr 12. PMID: 28412423.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Исламова М.Р., Лазарев П.В., Сафарова А.Ф., Кобалава Ж.Д. Значение дисфункции правого желудочка, правожелудочковоартериального сопряжения при хронической сердечной недостаточности: роль эхокардиографии. Кардиология. 2018;58(5):82–90. https://doi.org/10.18087/cardio.2018.5.10124</mixed-citation><mixed-citation xml:lang="en">6 Islamova M.R., Lazarev P.V., Safarova A.F., Kobalava Zh.D. The Value of Right Ventricular Dysfunction and Right Ventricular-Pulmonary Artery Coupling in Chronic Heart Failure: The Role of Echocardiography. Kardiologiia. 2018;58(5):82–90. (In Russ.). https://doi.org/10.18087/cardio. 2018.5.10124</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ishiwata J, Daimon M, Nakanishi K, Sugimoto T, Kawata T, Shinozaki T, Nakao T, Hirokawa M, Sawada N, Yoshida Y, Amiya E, Hatano M, Morita H, Yatomi Y, Komuro I. Combined evaluation of right ventricular function using echocardiography in non-ischaemic dilated cardiomyopathy. ESC Heart Fail. 2021 Oct;8(5):3947-3956. https://doi.org/10.1002/ehf2.13519. Epub 2021 Aug 4. PMID: 34346188; PMCID: PMC8497345.</mixed-citation><mixed-citation xml:lang="en">7 Ishiwata J, Daimon M, Nakanishi K, Sugimoto T, Kawata T, Shinozaki T, Nakao T, Hirokawa M, Sawada N, Yoshida Y, Amiya E, Hatano M, Morita H, Yatomi Y, Komuro I. Combined evaluation of right ventricular function using echocardiography in non-ischaemic dilated cardiomyopathy. ESC Heart Fail. 2021 Oct;8(5):3947-3956. https://doi.org/10.1002/ehf2.13519. Epub 2021 Aug 4. PMID: 34346188; PMCID: PMC8497345.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jentzer JC, Anavekar NS, Reddy YNV, Murphree DH, Wiley BM, Oh JK, Borlaug BA. Right Ventricular Pulmonary Artery Coupling and Mortality in Cardiac Intensive Care Unit Patients. J Am Heart Assoc. 2021 Apr 6;10(7):e019015. https://doi.org/10.1161/JAHA.120.019015. Epub 2021 Mar 28. PMID: 33775107; PMCID: PMC8174347.</mixed-citation><mixed-citation xml:lang="en">8 Jentzer JC, Anavekar NS, Reddy YNV, Murphree DH, Wiley BM, Oh JK, Borlaug BA. Right Ventricular Pulmonary Artery Coupling and Mortality in Cardiac Intensive Care Unit Patients. J Am Heart Assoc. 2021 Apr 6;10(7):e019015. https://doi.org/10.1161/JAHA.120.019015. Epub 2021 Mar 28. PMID: 33775107; PMCID: PMC8174347.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fortuni F, Butcher SC, Dietz MF, van der Bijl P, Prihadi EA, De Ferrari GM, Ajmone Marsan N, Bax JJ, Delgado V. Right Ventricular-Pulmonary Arterial Coupling in Secondary Tricuspid Regurgitation. Am J Cardiol. 2021 Jun 1;148:138-145. https://doi.org/10.1016/j.amjcard.2021.02.037. Epub 2021 Mar 3. PMID: 33667451.</mixed-citation><mixed-citation xml:lang="en">9 Fortuni F, Butcher SC, Dietz MF, van der Bijl P, Prihadi EA, De Ferrari GM, Ajmone Marsan N, Bax JJ, Delgado V. Right Ventricular-Pulmonary Arterial Coupling in Secondary Tricuspid Regurgitation. Am J Cardiol. 2021 Jun 1;148:138-145. https://doi.org/10.1016/j.amjcard.2021.02.037. Epub 2021 Mar 3. PMID: 33667451.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrara F., Rudski L.G., Vriz O., Gargani L., Afilalo J., D'Andrea A., D'Alto M., Marra A.M., Acri E., Stanziola A.A., Ghio S., Cittadini A., Naeije R., Bossone E. Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects. Int. J. Cardiol. 2016;223:736–743. https://doi.org/10.1016/j.ijcard.2016.08.275</mixed-citation><mixed-citation xml:lang="en">10 Ferrara F., Rudski L.G., Vriz O., Gargani L., Afilalo J., D'Andrea A., D'Alto M., Marra A.M., Acri E., Stanziola A.A., Ghio S., Cittadini A., Naeije R., Bossone E. Physiologic correlates of tricuspid annular plane systolic excursion in 1168 healthy subjects. Int. J. Cardiol. 2016;223:736–743. https://doi.org/10.1016/j.ijcard.2016.08.275</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bosch L, Lam CSP, Gong L, Chan SP, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Ng TP, Richards AM, Arslan F, Ling LH. Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. Eur J Heart Fail. 2017 Dec;19(12):1664-1671. https://doi.org/10.1002/ejhf.873. Epub 2017 Jun 8. PMID: 28597497.</mixed-citation><mixed-citation xml:lang="en">11 Bosch L, Lam CSP, Gong L, Chan SP, Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Ng TP, Richards AM, Arslan F, Ling LH. Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. Eur J Heart Fail. 2017 Dec;19(12):1664-1671. https://doi.org/10.1002/ejhf.873. Epub 2017 Jun 8. PMID: 28597497.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rudski L.G., Lai W.W., Afilalo J., Hua L., Handschumacher M.D., Chandrasekaran K., Solomon S.D., Louie E.K., Schiller N.B. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J. Am. Soc. Echocardiogr. 2010;23(7):685–713. https://doi.org/10.1016/j.echo.2010.05.010</mixed-citation><mixed-citation xml:lang="en">12 Rudski L.G., Lai W.W., Afilalo J., Hua L., Handschumacher M.D., Chandrasekaran K., Solomon S.D., Louie E.K., Schiller N.B. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J. Am. Soc. Echocardiogr. 2010;23(7):685–713. https://doi.org/10.1016/j.echo.2010.05.010</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mukherjee M, Rudski LG, Addetia K, Afilalo J, D'Alto M, Freed BH, Friend LB, Gargani L, Grapsa J, Hassoun PM, Hua L, Kim J, Mercurio V, Saggar R, Vonk-Noordegraaf A. Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2025 Mar;38(3):141186. https://doi.org/10.1016/j.echo.2025.01.006. PMID: 40044341.</mixed-citation><mixed-citation xml:lang="en">13 Mukherjee M, Rudski LG, Addetia K, Afilalo J, D'Alto M, Freed BH, Friend LB, Gargani L, Grapsa J, Hassoun PM, Hua L, Kim J, Mercurio V, Saggar R, Vonk-Noordegraaf A. Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2025 Mar;38(3):141186. https://doi.org/10.1016/j.echo.2025.01.006. PMID: 40044341.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Галявич А.С., Терещенко С.Н., Ускач Т.М., Агеев Ф.Т., Аронов Д.М., Арутюнов Г.П., Беграмбекова Ю.Л. и др. Хроническая сердечная недостаточность. Клинические рекомендации 2024. Российский кардиологический журнал. 2024;29(11):6162. https://doi.org/10.15829/1560-4071-2024-6162</mixed-citation><mixed-citation xml:lang="en">14 Galyavich A.S., Tereshchenko S.N., Uskach T.M., Ageev F.T., Aronov D.M., Arutyunov G.P., Begrambekova Yu.L. et al. 2024 Clinical practice guidelines for Chronic heart failure. Russian Journal of Cardiology. 2024;29(11):6162. (In Russ.) https://doi.org/10.15829/1560-4071-2024-6162</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ghio S, Guazzi M, Scardovi AB, Klersy C, Clemenza F, Carluccio E, Temporelli PL, Rossi A, Faggiano P, Traversi E, Vriz O, Dini FL; all investigators. Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction. Eur J Heart Fail. 2017 Jul;19(7):873-879. https://doi.org/10.1002/ejhf.664. Epub 2016 Nov 17. PMID: 27860029.</mixed-citation><mixed-citation xml:lang="en">15 Ghio S, Guazzi M, Scardovi AB, Klersy C, Clemenza F, Carluccio E, Temporelli PL, Rossi A, Faggiano P, Traversi E, Vriz O, Dini FL; all investigators. Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction. Eur J Heart Fail. 2017 Jul;19(7):873-879. https://doi.org/10.1002/ejhf.664. Epub 2016 Nov 17. PMID: 27860029.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rako ZA, Kremer N, Yogeswaran A, Richter MJ, Tello K. Adaptive versus maladaptive right ventricular remodelling. ESC Heart Fail. 2023 Apr;10(2):762-775. https://doi.org/10.1002/ehf2.14233. Epub 2022 Nov 23. PMID: 36419369; PMCID: PMC10053363.</mixed-citation><mixed-citation xml:lang="en">16 Rako ZA, Kremer N, Yogeswaran A, Richter MJ, Tello K. Adaptive versus maladaptive right ventricular remodelling. ESC Heart Fail. 2023 Apr;10(2):762-775. https://doi.org/10.1002/ehf2.14233. Epub 2022 Nov 23. PMID: 36419369; PMCID: PMC10053363.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Brener MI, Grayburn P, Lindenfeld J, Burkhoff D, Liu M, Zhou Z, Alu MC, Medvedofsky DA, Asch FM, Weissman NJ, Bax J, Abraham W, Mack MJ, Stone GW, Hahn RT. Right Ventricular-Pulmonary Arterial Coupling in Patients With HF Secondary MR: Analysis From the COAPT Trial. JACC Cardiovasc Interv. 2021 Oct 25;14(20):2231-2242. https://doi.org/10.1016/j.jcin.2021.07.047. PMID: 34674862.</mixed-citation><mixed-citation xml:lang="en">17 Brener MI, Grayburn P, Lindenfeld J, Burkhoff D, Liu M, Zhou Z, Alu MC, Medvedofsky DA, Asch FM, Weissman NJ, Bax J, Abraham W, Mack MJ, Stone GW, Hahn RT. Right Ventricular-Pulmonary Arterial Coupling in Patients With HF Secondary MR: Analysis From the COAPT Trial. JACC Cardiovasc Interv. 2021 Oct 25;14(20):2231-2242. https://doi.org/10.1016/j.jcin.2021.07.047. PMID: 34674862.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Iacoviello M, Monitillo F, Citarelli G, Leone M, Grande D, Antoncecchi V, Rizzo C, Terlizzese P, Romito R, Caldarola P, Ciccone MM. Right ventriculo-arterial coupling assessed by two-dimensional strain: A new parameter of right ventricular function independently associated with prognosis in chronic heart failure patients. Int J Cardiol. 2017 Aug 15;241:318-321. https://doi.org/10.1016/j.ijcard.2017.04.051. Epub 2017 May 1. PMID: 28479093.</mixed-citation><mixed-citation xml:lang="en">18 Iacoviello M, Monitillo F, Citarelli G, Leone M, Grande D, Antoncecchi V, Rizzo C, Terlizzese P, Romito R, Caldarola P, Ciccone MM. Right ventriculo-arterial coupling assessed by two-dimensional strain: A new parameter of right ventricular function independently associated with prognosis in chronic heart failure patients. Int J Cardiol. 2017 Aug 15;241:318-321. https://doi.org/10.1016/j.ijcard.2017.04.051. Epub 2017 May 1. PMID: 28479093.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Wu VC, Takeuchi M. Echocardiographic assessment of right ventricular systolic function. Cardiovasc Diagn Ther. 2018;8(1):70-79. doi:10.21037/cdt.2017.06.05</mixed-citation><mixed-citation xml:lang="en">19 Wu VC, Takeuchi M. Echocardiographic assessment of right ventricular systolic function. Cardiovasc Diagn Ther. 2018;8(1):70-79. doi:10.21037/cdt.2017.06.05</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kittipovanonth M, Bellavia D, Chandrasekaran K, Villarraga HR, Abraham TP, Pellikka PA. Doppler myocardial imaging for early detection of right ventricular dysfunction in patients with pulmonary hypertension. J Am Soc Echocardiogr. 2008;21(9):1035-1041.</mixed-citation><mixed-citation xml:lang="en">20 Kittipovanonth M, Bellavia D, Chandrasekaran K, Villarraga HR, Abraham TP, Pellikka PA. Doppler myocardial imaging for early detection of right ventricular dysfunction in patients with pulmonary hypertension. J Am Soc Echocardiogr. 2008;21(9):1035-1041.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
