vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2025.3.PHYS.1vmireaviz-1215Research ArticleФизиологияPhysiologyЭкспериментальные поиски препаратов для лечения фибрилляции предсердий (литературный обзор)Experimental search for drugs for the treatment of atrial fibrillation (literature review)https://orcid.org/0000-0002-4808-1546АбдуллаевА. А.AbdullaevA. A.

Абдуллаев Алигаджи Абдуллаевич - Д-р мед. наук, профессор, заведующий кафедры кардиологии, скорой помощи и общей врачебной практики ФПК и ППС Вклад автора: разработка концепции исследования.

пл. Ленина, д. 1, г. Махачкала, 367000

Alijadzhi А. Abdullaev - Dr. Sci. (Med.), Professor, Head of the Department of Cardiology, Emergency Care and General Medical Practice, Faculty of Advanced Training and PPS Author's contribution: development of the research concept.

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0001-5446-1775КудаевМ. Т.KudaevM. T.

Кудаев Магомед Тагирович - Д-р мед. наук, профессор, заведующий кафедры терапии ФПК и ППС Вклад автора: обсуждение результатов.

пл. Ленина, д. 1, г. Махачкала, 367000

Magomed Т. Kudayev - Dr. Sci. (Med.), Professor, Head of the Department of Therapy, Faculty of Advanced Training and Professional Development Author's contribution: discussion of results.

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0003-2483-5937МахмудоваЭ. Р.MakhmudovaE. R.

Махмудова Эльмира Рашитбековна - Канд. мед. наук, ассистент кафедры терапии ФПК и ППС Вклад автора: анализ литературных данных.

пл. Ленина, д. 1, г. Махачкала, 367000

Elmira R. Makhmudova - Cand. Sci. (Med.), Assistant of the Department of Therapy of Faculty of advanced training and professional retraining of specialists Author contribution: analysis of literature data.

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0002-8174-3900ХабчабовР. Г.KhabchabovR. G.

Хабчабов Рустам Газимагомедович - Канд. мед. наук, доцент кафедры кардиологии, скорой помощи и общей врачебной практики ФПК и ППС Вклад автора: степень новизны.

пл. Ленина, д. 1, г. Махачкала, 367000

Rustam G. Khabchabov - Cand. Sci. (Med.), Associate Professor of the Department of Cardiology, Emergency Care and General Medical Practice, Faculty of Advanced Training and PPS Author's contribution: degree of novelty.

Lenin Square, 1, Makhachkala, 367000

rustam033@gmail.comhttps://orcid.org/0000-0001-6790-1020ГафуроваР. М.GafurovaR. M.

Гафурова Разият Магомедтагировна - Доктор медицинских наук, доцент кафедры кардиологии, скорой помощи и общей врачебной практики ФПК и ППС Вклад автора: обсуждение полученных результатов.

пл. Ленина, д. 1, г. Махачкала, 367000

Raziyat M. Gafurova - Doctor of Medical Sciences, Associate Professor of the Department of Cardiology, Emergency Care and General Medical Practice, Faculty of Advanced Training and PPS Author's contribution: discussion of the obtained results.

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0002-1280-1505ИсламоваУ. А.IslamovaU. A.

Исламова Уммет Абдулхакимовна - Канд. мед. наук, доцент кафедры кардиологии, скорой помощи и общей врачебной практики ФПК и ППС Вклад автора: обработка данных.

пл. Ленина, д. 1, г. Махачкала, 367000

Ummet A. Islamova - Islamova Ummet Abdulkhakimovna Cand. Sci. (Med.), Associate Professor of the Department of Cardiology, Emergency Care and General Medical Practice, Faculty of Advanced Training and PPS Author's contribution: data processing

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0002-6009-9511АнатоваА. А.AnatovaA. A.

Анатова Аминат Анатовна - Канд. мед. наук, ассистент кафедры кардиологии, скорой помощи и общей врачебной практики ФПК и ППС Вклад автора: обсуждение обзора.

пл. Ленина, д. 1, г. Махачкала, 367000

Aminat A. Anatova - Cand. Sci. (Med.), Assistant Professor, Department of Cardiology, Emergency Care and General Medical Practice, Faculty of Advanced Training and PPS Author's contribution: discussion of the review.

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0001-6789-8853ДжанбулатовМ. А.DzhanbulatovM. A.

Джанбулатов Мурат Абдулвагитович - Канд. мед. наук, доцент кафедры стоматологии ФПК и ППС Вклад автора: дизайн обзора.

пл. Ленина, д. 1, г. Махачкала, 367000

Murat A. Dzhanbulatov - Cand. Sci. (Med.), Associate Professor of the Department of Dentistry, Faculty of Advanced Training and PPS Author's contribution: review design.

Lenin Square, 1, Makhachkala, 367000

https://orcid.org/0000-0002-8935-220XАбдуллаеваА. М.AbdullaevaA. M.

Абдуллаева Аида Мурадовна - Студентка лечебного факультета 4 группа, 6 курс Вклад автора: поиск информации.

пл. Ленина, д. 1, г. Махачкала, 367000

Abdullaeva Aida Muradovna - Student of the medical faculty, 4th group, 6th year Author's contribution: Information retrieval.

Lenin Square, 1, Makhachkala, 367000

Дагестанский государственный медицинский университетРоссияDagestan State Medical UniversityRussian Federation2025010820251533141Copyright © Абдуллаев А.А., Кудаев М.Т., Махмудова Э.Р., Хабчабов Р.Г., Гафурова Р.М., Исламова У.А., Анатова А.А., Джанбулатов М.А., Абдуллаева А.М., 20252025Абдуллаев А.А., Кудаев М.Т., Махмудова Э.Р., Хабчабов Р.Г., Гафурова Р.М., Исламова У.А., Анатова А.А., Джанбулатов М.А., Абдуллаева А.М.Abdullaev A.A., Kudaev M.T., Makhmudova E.R., Khabchabov R.G., Gafurova R.M., Islamova U.A., Anatova A.A., Dzhanbulatov M.A., Abdullaeva A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/1215

Фибрилляция предсердий или мерцательная аритмия является самым распространённым нарушением ритма сердца с частыми осложнениями. Несмотря на столетие исследования и предположения, механизмы, лежащие в основе фибрилляции предсердий, так и не были до конца установлены, а терапия, особенно постоянной формы, остаётся неоптимальной. Назначение современных антиаритмических препаратов связано со значительным уровнем побочных эффектов, особенно проаритмическими. Многие пациенты с выраженной симптоматикой фибрилляции предсердий не получают терапии для контроля ритма. В этом обзоре основное внимание уделено фармакологическим разработкам в лечении фибрилляции предсердий. Проанализирован нынешний статус некоторых антиаритмических препаратов и их дальнейшая возможность в терапии ФП, рассмотрены молекулярные механизмы и клиническое использование некоторых селективных для предсердий антифибрилляторных препаратов. Подробно описаны ключевые фармакодинамические и фармакокинетические свойства этих препаратов с целью предупреждения проаритмических эффектов, а также препаратов, влияющих на ремоделирование предсердий, воспаление и фиброз, которые проходят тестирования в качестве потенциальных методов лечения фибрилляции предсердий.

Atrial fibrillation is the most common cardiac arrhythmia with frequent complications. Despite a century of research and speculation, the mechanisms underlying AF have not been fully elucidated, and therapy, especially for the permanent form, remains suboptimal. The use of modern antiarrhythmic drugs is associated with a significant level of side effects, especially proarrhythmic ones. Many patients with severe atrial fibrillation symptoms do not receive any therapy for rhythm control. In this review, the main focus will be on pharmacological developments in the treatment of atrial fibrillation. We will discuss the current status of some antiarrhythmic drugs and their future potential in the treatment of atrial fibrillation, reviewing the molecular mechanisms and clinical use of some atrial-selective antifibrillatory drugs. We will review in detail the key pharmacodynamic and pharmacokinetic properties of these drugs in order to prevent proarrhythmic effects. As well as drugs that affect atrial remodeling, inflammation and fibrosis, which are being tested as potential treatments for atrial fibrillation.

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The authors declare that there are no conflicts of interest present.