vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2025.3.CLIN.4vmireaviz-1264Research ArticleКлиническая медицинаClinical medicineСиндром обратимой задней энцефалопатии (обзор литературы)Posterior reversible encephalopathy syndrome (literature review)https://orcid.org/0000-0002-8490-1417КовалеваЭ. А.KovalevaE. A.

Ковалева Элла Александровна - Канд. мед. наук, старший научный сотрудник научного отделения неотложной неврологии и восстановительного лечения, старший преподаватель учебного отдела, врач-невролог неврологического отделения для больных с острыми нарушениями мозгового кровообращения Вклад автора: дизайн работы, научное редактирование текста.

Большая Сухаревская пл., д. 3, г. Москва, 129090

Ella A. Kovaleva - Cand. Sci. (Med.), Senior Researcher, Department of Emergency Neurology and Rehabilitation, Senior Lecturer, Educational Department, Neurologist, Department of Neurology for Patients with Acute Cerebrovascular Accidents Author's contribution: design of the work, scientific editing of the text.

3, Bolshaya Sukharevskaya Square, Moscow, 129090

kovalevaea@sklif.mos.ruhttps://orcid.org/0000-0001-8096-5029АхматхановаЛ. Х.-Б.AkhmatkhanovaL. Kh.-B.

Ахматханова Лиана Хаваж-Баудиновна - Младший научный сотрудник научного отделения неотложной неврологии и восстановительного лечения Вклад автора: подбор и анализ источников литературы.

Большая Сухаревская пл., д. 3, г. Москва, 129090

Liana Kh.-B. Akhmatkhanova - Junior Researcher, Department of Emergency Neurology and Rehabilitation Author's contribution: selection and analysis of literature sources.

3, Bolshaya Sukharevskaya Square, Moscow, 129090

akhmatkhanovalkb@sklif.mos.ruhttps://orcid.org/0000-0002-0804-3190МагомедовТ. А.MagomedovT. A.

Магомедов Тимур Абдурахманович - Врач-невролог неврологического отделения для больных с острыми нарушениями мозгового кровообращения Вклад автора: подбор и анализ источников литературы.

Большая Сухаревская пл., д. 3, г. Москва, 129090

Timur A. Magomedov - Neurologist, neurological department for patients with acute cerebrovascular accidents Author's contribution: selection and analysis of literature sources.

3, Bolshaya Sukharevskaya Square, Moscow, 129090

magomedovta@sklif.mos.ruhttps://orcid.org/0000-0001-9750-3509ШевченкоЕ. В.ShevchenkoE. V.

Шевченко Евгений Владимирович - Канд. мед. наук, заведующий неврологическим отделением для больных с острыми нарушениями мозгового кровообращения, старший научный сотрудник научного отделения неотложной неврологии и восстановительного лечения Вклад автора: дизайн работы, научное редактирование текста.

Большая Сухаревская пл., д. 3, г. Москва, 129090

Evgeniy V. Shevchenko - Cand. Sci. (Med.), head of the neurological department for patients with acute cerebrovascular accidents, senior researcher, scientific department of emergency neurology and rehabilitation treatment Author's contribution: design of the work, scientific editing of the text.

3, Bolshaya Sukharevskaya Square, Moscow, 129090

shevchenkoev@sklif.mos.ruhttps://orcid.org/0009-0000-5936-8182ХаховаМ. М.KhakhovaM. M.

Хахова Мадина Мухамедхановна - Младший научный сотрудник научного отделения неотложной неврологии и восстановительного лечения Вклад автора: подбор и анализ источников литературы.

Большая Сухаревская пл., д. 3, г. Москва, 129090

Madina M. Khakhova - Junior Researcher, Scientific Department of Emergency Neurology and Rehabilitation Treatment Author's contribution: selection and analysis of literature sources.

3, Bolshaya Sukharevskaya Square, Moscow, 129090

khakhovamm@sklif.mos.ruhttps://orcid.org/0000-0001-6824-4114РамазановГ. Р.RamazanovG. R.

Рамазанов Ганипа Рамазанович - Канд. мед. наук, заместитель директора – руководитель регионального сосудистого центра; заведующий научным отделением неотложной неврологии и восстановительного лечения Вклад автора: дизайн работы, научное редактирование текста.

Большая Сухаревская пл., д. 3, г. Москва, 129090

Ganipa R. Ramazanov - Cand. Sci. (Med.), Deputy Director – Head of the Regional Vascular Center; Head of the Scientific Department of Emergency Neurology and Rehabilitation Treatment Author's contribution: design of the work, scientific editing of the text.

3, Bolshaya Sukharevskaya Square, Moscow, 129090

ramazanovgr@sklif.mos.ruНаучно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute for Emergency MedicineRussian Federation202501082025153109117Copyright © Ковалева Э.А., Ахматханова Л.Х., Магомедов Т.А., Шевченко Е.В., Хахова М.М., Рамазанов Г.Р., 20252025Ковалева Э.А., Ахматханова Л.Х., Магомедов Т.А., Шевченко Е.В., Хахова М.М., Рамазанов Г.Р.Kovaleva E.A., Akhmatkhanova L.K., Magomedov T.A., Shevchenko E.V., Khakhova M.M., Ramazanov G.R.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/1264

Синдром обратимой задней энцефалопатии (СОЗЭ, Posterior Reversible Encephalopathy Syndrome (PRES)) – клиникорадиологический синдром, характеризующийся острой церебральной эндотелиопатией, нарушением проницаемости гематоэнцефалического барьера с формированием вазогенного отёка белого вещества головного мозга, преимущественно затылочной и теменной долей и, как следствие, развитием таких клинических проявлений, как головная боль, снижение уровня бодрствования, эпилептические приступы и зрительные расстройства. Изначально данное заболевание связывали только с артериальной гипертензией, однако в последствии исследования показали, что синдром обратимой задней энцефалопатии может быть вызван и другими факторами, такими как инфекции, болезни почек или использование определённых лекарственных препаратов. В данной статье рассмотрены основные причины возникновения синдрома обратимой задней энцефалопатии, клинические проявления и методы верификации, а также принципы лечения данного состояния.

Posterior Reversible Encephalopathy Syndrome (PRES) – a clinical and radiological syndrome characterized by acute cerebral endotheliopathy, impaired permeability of the blood-brain barrier with limitations of vasogenic cerebral edema, usually of the occipital and posterior lobes, and known to develop mental illnesses such as headache, decreased alertness, seizures, and visual disturbances. The initial manifestations of the disease are associated only with arterial hypertension, but after investigating the phenomenon, PRES can also be caused by other factors such as infections, kidney disease, or the use of certain medications. This article will discuss the main causes of PRES, the consequences and methods of verifying the manifestation, as well as the principles of treatment of this condition.

синдром обратимой задней энцефалопатии [C10.228.140.199]вазогенный отек [C10.228.140.199]гематоэнцефалический барьер [A05.810.453.736.520.200]артериальная гипертензия [C14.907.489]эпилептические приступы [C10.228.140.546.800]иммуносупрессанты [D27.505.519.625.120.400]магнитно-резонансная томография [E01.370.350.350.810.334.500]церебральная эндотелиопатия [A07.231.432.410]неврологический дефицит [C10]нейровизуализация [E01.370.350.350]posterior reversible encephalopathy syndrome / Brain Edema [C10.228.140.199]vasogenic edema / Brain Edema [C10.228.140.199]blood-brain barrier [A05.810.453.736.520.200]arterial hypertension / Hypertension [C14.907.489]epileptic seizures / Seizures [C10.228.140.546.800]immunosuppressants / Immunosuppressive Agents [D27.505.519.625.120.400]magnetic resonance imaging [E01.370.350.350.810.334.500]cerebral endotheliopathy / EndotheliumVascular [A07.231.432.410]neurological deficit / Nervous System Diseases [C10]neuroimaging [E01.370.350.350]ReferencesGewirtz AN, Gao V, Parauda SC, Robbins MS. Posterior Reversible Encephalopathy Syndrome. Curr Pain Headache Rep. 2021;25(3):19. PMID: 33630183 https://doi.org/10.1007/s11916-020-00932-1Gewirtz AN, Gao V, Parauda SC, Robbins MS. Posterior Reversible Encephalopathy Syndrome. Curr Pain Headache Rep. 2021;25(3):19. PMID: 33630183 https://doi.org/10.1007/s11916-020-00932-1Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494-500. PMID: 8559202 https://doi.org/10.1056/NEJM199602223340803Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494-500. PMID: 8559202 https://doi.org/10.1056/NEJM199602223340803Скворцова В.И., Губский Л.В., Мельникова Е.А. Синдром задней обратимой энцефалопатии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2010;110(5):104-109.Skvortsova VI, Gubskiĭ LV, Mel'nikova EA. Posterior reversible encephalopathy syndrome. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2010;110(5):104-109. (In Russ.)Добрынина Л.А., Калашникова Л.А., Бакулин И.С., Кремнева Е.И., Кротенкова М.В., Шамтиева К.В. Синдром задней обратимой энцефалопатии при гипокальциемии: описание наблюдения и анализ патогенетической значимости электролитных нарушений. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(7):70–77. https://doi.org/10.17116/jnevro20161167170-77Dobrynina LA, Kalashnikova LA, Bakulin IS, Kremneva EI, Krotenkova MV, Shamtieva KV. Sindrom zadnei obratimoi entsefalopatii pri gipokal'tsiemii: opisanie nabliudeniia i analiz patogeneticheskoi znachimosti elektrolitnykh narushenii. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2016;116(7):70–77. (In Russ.) https://doi.org/10.17116/jnevro20161167170-77Farid H, Tatum JK, Wong C, Halbach VV, Hetts SW. Reversible cerebral vasoconstriction syndrome: treatment with combined intra-arterial verapamil infusion and intracranial angioplasty. AJNR Am J Neuroradiol. 2011;32(10):E184-E187. PMID: 21273351 https://doi.org/10.3174/ajnr.A2341Farid H, Tatum JK, Wong C, Halbach VV, Hetts SW. Reversible cerebral vasoconstriction syndrome: treatment with combined intra-arterial verapamil infusion and intracranial angioplasty. AJNR Am J Neuroradiol. 2011;32(10):E184-E187. PMID: 21273351 https://doi.org/10.3174/ajnr.A2341Рамазанов Г.Р., Магомедов Т.А., Соловцова М.С., Шевченко Е.В., Ковалева Э.А. Синдром обратимой церебральной вазоконстрикции. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2024;13(3):492-500. https://doi.org/10.23934/2223-9022-2024-13-3-492-500Ramazanov GR, Magomedov TA, Solovtsova MS, Shevchenko EV, Kovaleva EA. Reversible Cerebral Vasoconstriction Syndrome. Russian Sklifosovsky Journal "Emergency Medical Care". 2024;13(3):492-500. (In Russ.) https://doi.org/10.23934/2223-9022-2024-13-3-492-500Granata G, Greco A, Iannella G, Granata M, Manno A, Savastano E, et al. Posterior reversible encephalopathy syndrome--Insight into pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2015;14(9):830-836. PMID: 25999210 https://doi.org/10.1016/j.autrev.2015.05.006Granata G, Greco A, Iannella G, Granata M, Manno A, Savastano E, et al. Posterior reversible encephalopathy syndrome--Insight into pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2015;14(9):830-836. PMID: 25999210 https://doi.org/10.1016/j.autrev.2015.05.006Pilato F, Distefano M, Calandrelli R. Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome: clinical and radiological considerations. Front Neurol. 2020;11:34. PMID: 32117007 https://doi.org/10.3389/fneur.2020.00034 eCollection 2020.Pilato F, Distefano M, Calandrelli R. Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome: clinical and radiological considerations. Front Neurol. 2020;11:34. PMID: 32117007 https://doi.org/10.3389/fneur.2020.00034 eCollection 2020.Leroux G, Sellam J, Costedoat-Chalumeau N, Le Thi Huong D, Combes A, Tieulié N, et al. Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literature. Lupus. 2008;17(2):139-147. PMID: 18250139 https://doi.org/10.1177/0961203307085405Leroux G, Sellam J, Costedoat-Chalumeau N, Le Thi Huong D, Combes A, Tieulié N, et al. Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literature. Lupus. 2008;17(2):139-147. PMID: 18250139 https://doi.org/10.1177/0961203307085405Petrović B, Kostić V, Sternić N, Kolar J, Tasić N. Posterior reversible encephalopathy syndrome. Srp Arh Celok Lek. 2003;131(11-12):461-466. PMID: 15114789 https://doi.org/10.2298/sarh0312461pPetrović B, Kostić V, Sternić N, Kolar J, Tasić N. Posterior reversible encephalopathy syndrome. Srp Arh Celok Lek. 2003;131(11-12):461-466. PMID: 15114789 https://doi.org/10.2298/sarh0312461pThavamani A, Umapathi KK, Puliyel M, Super D, Allareddy V, Ghori A. Epidemiology, comorbidities, and outcomes of posterior reversible encephalopathy syndrome in children in the United States. Pediatr Neurol. 2020;103:21-26. PMID: 31481327 https://doi.org/10.1016/j.pediatrneurol.2019.07.007Thavamani A, Umapathi KK, Puliyel M, Super D, Allareddy V, Ghori A. Epidemiology, comorbidities, and outcomes of posterior reversible encephalopathy syndrome in children in the United States. Pediatr Neurol. 2020;103:21-26. PMID: 31481327 https://doi.org/10.1016/j.pediatrneurol.2019.07.007Buchhanolla P, Bir S, Angelette A, Lewis A, Kandregula S, Guthikonda B, et al. Determination of Prevalence of Posterior Reversible Encephalopathy Syndrome (PRES) and Its Association with Cerebral Infarction, and Outcome in the Nationwide Inpatient Sample, 2016–2018 (P16- 10.002). Neurology. 2022;98(18, Suppl). https://doi.org/10.1212/WNL.98.18_supplement.3555Buchhanolla P, Bir S, Angelette A, Lewis A, Kandregula S, Guthikonda B, et al. Determination of Prevalence of Posterior Reversible Encephalopathy Syndrome (PRES) and Its Association with Cerebral Infarction, and Outcome in the Nationwide Inpatient Sample, 2016–2018 (P16- 10.002). Neurology. 2022;98(18, Suppl). https://doi.org/10.1212/WNL.98.18_supplement.3555Raj S, Overby P, Erdfarb A, Ushay HM. Posterior reversible encephalopathy syndrome: incidence and associated factors in a pediatric critical care population. Pediatr Neurol. 2013;49(5):335–339. PMID: 23916861 https://doi.org/10.1016/j.pediatrneurol.2013.06.007Raj S, Overby P, Erdfarb A, Ushay HM. Posterior reversible encephalopathy syndrome: incidence and associated factors in a pediatric critical care population. Pediatr Neurol. 2013;49(5):335–339. PMID: 23916861 https://doi.org/10.1016/j.pediatrneurol.2013.06.007Khademian Z, Speller-Brown B, Nouraie SM, Minniti CP. Reversible posterior leuko-encephalopathy in children with sickle cell disease. Pediatr Blood Cancer. 2009;52(3):373–375. PMID: 19003906 https://doi.org/10.1002/pbc.21812Khademian Z, Speller-Brown B, Nouraie SM, Minniti CP. Reversible posterior leuko-encephalopathy in children with sickle cell disease. Pediatr Blood Cancer. 2009;52(3):373–375. PMID: 19003906 https://doi.org/10.1002/pbc.21812Masetti R, Cordelli DM, Zama D, Vendemini F, Biagi C, Franzoni E, et al. PRES in children undergoing hematopoietic stem cell or solid organ transplantation. Pediatrics. 2015;135(5):890-901. PMID: 25917987 https://doi.org/10.1542/peds.2014-2325Masetti R, Cordelli DM, Zama D, Vendemini F, Biagi C, Franzoni E, et al. PRES in children undergoing hematopoietic stem cell or solid organ transplantation. Pediatrics. 2015;135(5):890-901. PMID: 25917987 https://doi.org/10.1542/peds.2014-2325Lin E, Lantos JE, Strauss SB, Phillips CD, Campion TR Jr, Navi BB, et al. Brain Imaging of Patients with COVID-19: Findings at an Academic Institution during the Height of the Outbreak in New York City. AJNR Am J Neuroradiol. 2020;41(11):2001-2008. PMID: 32819899 https://doi.org/10.3174/ajnr.A6793Lin E, Lantos JE, Strauss SB, Phillips CD, Campion TR Jr, Navi BB, et al. Brain Imaging of Patients with COVID-19: Findings at an Academic Institution during the Height of the Outbreak in New York City. AJNR Am J Neuroradiol. 2020;41(11):2001-2008. PMID: 32819899 https://doi.org/10.3174/ajnr.A6793Mayama M, Uno K, Tano S, Yoshihara M, Ukai M, Kishigami Y, et al. Incidence of posterior reversible encephalopathy syndrome in eclamptic and patients with preeclampsia with neurologic symptoms. Am J Obstet Gynecol. 2016;215(2):239.e1-5. PMID: 26902987 https://doi.org/10.1016/j.ajog.2016.02.039Mayama M, Uno K, Tano S, Yoshihara M, Ukai M, Kishigami Y, et al. Incidence of posterior reversible encephalopathy syndrome in eclamptic and patients with preeclampsia with neurologic symptoms. Am J Obstet Gynecol. 2016;215(2):239.e1-5. PMID: 26902987 https://doi.org/10.1016/j.ajog.2016.02.039Brewer J, Owens MY, Wallace K, Reeves AA, Morris R, Khan M, et al. Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia. Am J Obstet Gynecol. 2013;208(6):468.e1-6. PMID: 23395926 https://doi.org/10.1016/j.ajog.2013.02.015Brewer J, Owens MY, Wallace K, Reeves AA, Morris R, Khan M, et al. Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia. Am J Obstet Gynecol. 2013;208(6):468.e1-6. PMID: 23395926 https://doi.org/10.1016/j.ajog.2013.02.015Wagner SJ, Acquah LA, Lindell EP, Craici IM, Wingo MT, Rose CH, et al. Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more aggressive blood pressure control. Mayo Clin Proc. 2011;86(9):851-856. PMID: 21878596 https://doi.org/10.4065/mcp.2011.0090Wagner SJ, Acquah LA, Lindell EP, Craici IM, Wingo MT, Rose CH, et al. Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more aggressive blood pressure control. Mayo Clin Proc. 2011;86(9):851-856. PMID: 21878596 https://doi.org/10.4065/mcp.2011.0090Mergen S, Long B, Matlock A. Posterior Reversible Encephalopathy Syndrome: A Narrative Review for Emergency Clinicians. J Emerg Med. 2021;61(6):666-673. PMID: 34696929 https://doi.org/10.1016/j.jemermed.2021.09.005Mergen S, Long B, Matlock A. Posterior Reversible Encephalopathy Syndrome: A Narrative Review for Emergency Clinicians. J Emerg Med. 2021;61(6):666-673. PMID: 34696929 https://doi.org/10.1016/j.jemermed.2021.09.005Lee VH, Wijdicks EF, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008;65(2):205-210. PMID: 18268188 https://doi.org/10.1001/archneurol.2007.46Lee VH, Wijdicks EF, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008;65(2):205-210. PMID: 18268188 https://doi.org/10.1001/archneurol.2007.46Fugate JE, Claassen DO, Cloft HJ, Kallmes DF, Kozak OS, Rabinstein AA. Posterior reversible encephalopathy syndrome: associated clinical and radiologic finings. Mayo Clin Proc. 2010;85(5):427-432. PMID: 20435835 https://doi.org/10.4065/mcp.2009.0590Fugate JE, Claassen DO, Cloft HJ, Kallmes DF, Kozak OS, Rabinstein AA. Posterior reversible encephalopathy syndrome: associated clinical and radiologic finings. Mayo Clin Proc. 2010;85(5):427-432. PMID: 20435835 https://doi.org/10.4065/mcp.2009.0590Gewirtz AN, Gao V, Parauda SC, Robbins MS. Posterior Reversible Encephalopathy Syndrome. Curr Pain Headache Rep. 2021;25(3):19. PMID: 33630183 https://doi.org/10.1007/s11916-020-00932-1Gewirtz AN, Gao V, Parauda SC, Robbins MS. Posterior Reversible Encephalopathy Syndrome. Curr Pain Headache Rep. 2021;25(3):19. PMID: 33630183 https://doi.org/10.1007/s11916-020-00932-1Magaña SM, Matiello M, Pittock SJ, McKeon A, Lennon VA, Rabinstein AA, et al. Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disorders. Neurology. 2009;72(8):712-717. PMID: 19237699 https://doi.org/10.1212/01.wnl.0000343001.36493.aeMagaña SM, Matiello M, Pittock SJ, McKeon A, Lennon VA, Rabinstein AA, et al. Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disorders. Neurology. 2009;72(8):712-717. PMID: 19237699 https://doi.org/10.1212/01.wnl.0000343001.36493.aeFerreira TS, Reis F, Appenzeller S. Posterior reversible encephalopathy syndrome and association with systemic lupus erythematosus. Lupus. 2016;25(12):1369-76. PMID: 27084028 https://doi.org/10.1177/0961203316643598Ferreira TS, Reis F, Appenzeller S. Posterior reversible encephalopathy syndrome and association with systemic lupus erythematosus. Lupus. 2016;25(12):1369-76. PMID: 27084028 https://doi.org/10.1177/0961203316643598Dhar R. Neurologic complications of transplantation. Neurocrit Care. 2018;28(1):4-11. PMID: 28251577 https://doi.org/10.1007/s12028-017-0387-6Dhar R. Neurologic complications of transplantation. Neurocrit Care. 2018;28(1):4-11. PMID: 28251577 https://doi.org/10.1007/s12028-017-0387-6Chen S, Hu J, Xu L, Brandon D, Yu J, Zhang J. Posterior reversible encephalopathy syndrome after transplantation: a review. Mol Neurobiol. 2016;53(10):6897-6909. PMID: 26666662 https://doi.org/10.1007/s12035-015-9560-0Chen S, Hu J, Xu L, Brandon D, Yu J, Zhang J. Posterior reversible encephalopathy syndrome after transplantation: a review. Mol Neurobiol. 2016;53(10):6897-6909. PMID: 26666662 https://doi.org/10.1007/s12035-015-9560-0Parikh NS, Schweitzer AD, Young RJ, Giambrone AE, Lyo J, Karimi S, et al. Corticosteroid therapy and severity of vasogenic edema in posterior reversible encephalopathy syndrome. J Neurol Sci. 2017;380:11-15. PMID: 28870548 https://doi.org/10.1016/j.jns.2017.06.044Parikh NS, Schweitzer AD, Young RJ, Giambrone AE, Lyo J, Karimi S, et al. Corticosteroid therapy and severity of vasogenic edema in posterior reversible encephalopathy syndrome. J Neurol Sci. 2017;380:11-15. PMID: 28870548 https://doi.org/10.1016/j.jns.2017.06.044Wu Q, Marescaux C, Wolff V, Jeung MY, Kessler R, Lauer V, et al. Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation. Eur Neurol. 2010;64(3):169-177. PMID: 20699617 https://doi.org/10.1159/000319032Wu Q, Marescaux C, Wolff V, Jeung MY, Kessler R, Lauer V, et al. Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation. Eur Neurol. 2010;64(3):169-177. PMID: 20699617 https://doi.org/10.1159/000319032Bartynski WS, Tan HP, Boardman JF, Shapiro R, Marsh JW. Posterior reversible encephalopathy syndrome after solid organ transplantation. AJNR Am J Neuroradiol. 2008;29(5):924-30. PMID: 18272559 https://doi.org/10.3174/ajnr.A0960Bartynski WS, Tan HP, Boardman JF, Shapiro R, Marsh JW. Posterior reversible encephalopathy syndrome after solid organ transplantation. AJNR Am J Neuroradiol. 2008;29(5):924-30. PMID: 18272559 https://doi.org/10.3174/ajnr.A0960Chang JM, Hwang SJ, Kuo HT, Tsai JC, Guh JY, Chen HC, et al. Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. Am J Kidney Dis. 2000;35(2):189-193. PMID: 10676715 https://doi.org/10.1016/s0272-6386(00)70325-8Chang JM, Hwang SJ, Kuo HT, Tsai JC, Guh JY, Chen HC, et al. Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. Am J Kidney Dis. 2000;35(2):189-193. PMID: 10676715 https://doi.org/10.1016/s0272-6386(00)70325-8Chen CL, Chou KJ, Wang JS, Yeh JH, Fang HC, Chung HM. Neurotoxic effects of carambola in rats: the role of oxalate. J Formos Med Assoc. 2002;101(5):337-341. PMID: 12101851Chen CL, Chou KJ, Wang JS, Yeh JH, Fang HC, Chung HM. Neurotoxic effects of carambola in rats: the role of oxalate. J Formos Med Assoc. 2002;101(5):337-341. PMID: 12101851Wu XM, Wang GL, Kou CG, Wang JT, Liang JM, Yu YQ. Posterior reversible encephalopathy syndrome induced by food poisoning in a pediatric patient: a case report. J Int Med Res. 2020;48(12):300060520980201. PMID: 33349079 https://doi.org/10.1177/0300060520980201Wu XM, Wang GL, Kou CG, Wang JT, Liang JM, Yu YQ. Posterior reversible encephalopathy syndrome induced by food poisoning in a pediatric patient: a case report. J Int Med Res. 2020;48(12):300060520980201. PMID: 33349079 https://doi.org/10.1177/0300060520980201Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon. 2023 Mar 15;225:107054. PMID: 36801215 https://doi.org/10.1016/j.toxicon.2023.107054Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon. 2023 Mar 15;225:107054. PMID: 36801215 https://doi.org/10.1016/j.toxicon.2023.107054Li Y, Gor D, Walicki D, Jenny D, Jones D, Barbour P, et al. Spectrum and potential pathogenesis of reversible posterior leukoencephalopathy syndrome. J Stroke Cerebrovasc Dis. 2012;21(8):873-882. PMID: 21703874 https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.05.010Li Y, Gor D, Walicki D, Jenny D, Jones D, Barbour P, et al. Spectrum and potential pathogenesis of reversible posterior leukoencephalopathy syndrome. J Stroke Cerebrovasc Dis. 2012;21(8):873-882. PMID: 21703874 https://doi.org/10.1016/j.jstrokecerebrov asdis.2011.05.010Делягин В.М., Сердюк О.А., Балашов Д.Н. и др. Задняя обратимая лейкоэнцефалопатия у детей с гематологическими и онкологическими заболеваниями (собственные данные и анализ литературы). современная онкология. 2017;19(1):69–74.Delyagin V.M., Serdyuk O.A., Balashov D.N. et al. Posterior reversible encephalopathy syndrome in children with hematological and oncology diseases. Journal of Modern Oncology. 2017;19(1):69–74. (In Russ.)Ando Y, Ono Y, Sano A, Fujita N, Ono S. Posterior Reversible Encephalopathy Syndrome: A Review of the Literature. Intern Med. 2022;61(2):135-141. PMID: 34275982 https://doi.org/10.2169/internalmedicine.7520-21Ando Y, Ono Y, Sano A, Fujita N, Ono S. Posterior Reversible Encephalopathy Syndrome: A Review of the Literature. Intern Med. 2022;61(2):135-141. PMID: 34275982 https://doi.org/10.2169/internalmedicine.7520-21Mueller-Mang C, Mang T, Pirker A, Klein K, Prchla C, Prayer D. Posterior reversible encephalopathy syndrome:do predisposing risk factors make a difference in MRI appearance? Neuroradiology. 2009;51(6):373-383. PMID: 19234694 https://doi.org/10.1007/s00234-009-0504-0Mueller-Mang C, Mang T, Pirker A, Klein K, Prchla C, Prayer D. Posterior reversible encephalopathy syndrome:do predisposing risk factors make a difference in MRI appearance? Neuroradiology. 2009;51(6):373-383. PMID: 19234694 https://doi.org/10.1007/s00234-009- 0504-0Bartynski WS. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol. 2008;29(6):1043–1049. PMID: 18403560 https://doi.org/10.3174/ajnr.A0929Bartynski WS. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol. 2008;29(6):1043–1049. PMID: 18403560 https://doi.org/10.3174/ajnr.A0929Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol. 2015;14(9):914-925. PMID: 26184985 https://doi.org/10.1016/s1474-4422(15)00111-8Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol. 2015;14(9):914-925. PMID: 26184985 https://doi.org/10.1016/s1474-4422(15)00111-8Feske SK. Posterior reversible encephalopathy syndrome: a review. Semin Neurol. 2011;31(2):202-215. PMID: 21590625 https://doi.org/10.1055/s-0031-1277990Feske SK. Posterior reversible encephalopathy syndrome: a review. Semin Neurol. 2011;31(2):202-215. PMID: 21590625 https://doi.org/10.1055/s-0031-1277990Abdulla MC. Posterior reversible encephalopathy syndrome secondary to malignancy-associated hypercalcemia: A case report. Int J Crit Illn Inj Sci. 2023;13(4):199-201. PMID: 38292398 https://doi.org/10.4103/ijciis.ijciis_8_23Abdulla MC. Posterior reversible encephalopathy syndrome secondary to malignancy-associated hypercalcemia: A case report. Int J Crit Illn Inj Sci. 2023;13(4):199-201. PMID: 38292398 https://doi.org/10.4103/ijciis.ijciis_8_23Bartynski WS, Zeigler Z, Spearman MP, Lin L, Shadduck RK, Lister J. Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity. AJNR Am J Neuroradiol. 2001;22(10):1901–1914. PMID: 11733324Bartynski WS, Zeigler Z, Spearman MP, Lin L, Shadduck RK, Lister J. Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity. AJNR Am J Neuroradiol. 2001;22(10):1901–1914. PMID: 11733324Гудкова В.В., Кимельфельд Е.И., Стаховская Л.В. Малоизвестный синдром задней обратимой энцефалопатии, требующий неотложной помощи. Consilium Medicum. 2018;20(2):84–89.Gudkova VV, Kimel'fel'd EI, Stakhovskaya L.V. Maloizvestnyy sindrom zadney obratimoy entsefalopatii, trebuyushchiy neotlozhnoy pomoshchi. Consilium Medicum. 2018;20(2):84–89. (In Russ.) https://doi.org/10.26442/2075-1753_2018.2.84-89Lamy C, Oppenheim C, Mas JL. Posterior reversible encephalopathy syndrome. Handb Clin Neurol. 2014;121:1687-1701. PMID: 24365441 https://doi.org/10.1016/B978-0-7020-4088-7.00109-7Lamy C, Oppenheim C, Mas JL. Posterior reversible encephalopathy syndrome. Handb Clin Neurol. 2014;121:1687-1701. PMID: 24365441 https://doi.org/10.1016/B978-0-7020-4088-7.00109-7Hinduja A. Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome. Front Neurol. 2020 14;11:71. PMID: 32117030 https://doi.org/10.3389/fneur.2020.00071eCollection 2020.Hinduja A. Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome. Front Neurol. 2020 14;11:71. PMID: 32117030 https://doi.org/10.3389/fneur.2020.00071 eCollection 2020.Hinduja A, Habetz K, Raina SK, Fitzgerald RT, Sahaya K. Predictors of seizures in patients with posterior reversible encephalopathy syndrome. Epilepsy Behav. 2016;61:97-101. PMID: 27337161 https://doi.org/10.1016/j.yebeh.2016.05.001Hinduja A, Habetz K, Raina SK, Fitzgerald RT, Sahaya K. Predictors of seizures in patients with posterior reversible encephalopathy syndrome. Epilepsy Behav. 2016;61:97-101. PMID: 27337161 https://doi.org/10.1016/j.yebeh.2016.05.001Lifson N, Pasquale A, Salloum G, Alpert S. Ophthalmic Manifestations of Posterior Reversible Encephalopathy Syndrome. Neuroophthalmology. 2018;43(3):180-184. PMID: 31312242 https://doi.org/10.1080/01658107.2018.1506938Lifson N, Pasquale A, Salloum G, Alpert S. Ophthalmic Manifestations of Posterior Reversible Encephalopathy Syndrome. Neuroophthalmology. 2018;43(3):180-184. PMID: 31312242 https://doi.org/10.1080/01658107.2018.1506938Liman TG, Bohner G, Heuschmann PU, Scheel M, Endres M, Siebert E. Clinical and radiological differences in posterior reversible encephalopathy syndrome between patients with preeclampsia-eclampsia and other predisposing diseases. Eur J Neurol. 2012;19(7):935-943. PMID: 22248235 https://doi.org/10.1111/j.1568-1331.2011.03629.xLiman TG, Bohner G, Heuschmann PU, Scheel M, Endres M, Siebert E. Clinical and radiological differences in posterior reversible encephalopathy syndrome between patients with preeclampsia-eclampsia and other predisposing diseases. Eur J Neurol. 2012;19(7):935-943. PMID: 22248235 https://doi.org/10.1111/j.1568-1331.2011.03629.xMiller R, Wagner S, Hammond J, Roberts N, Marshall K, Barth B. Posterior reversible encephalopathy syndrome in the emergency department: A single center retrospective study. Am J Emerg Med. 2021;45:61-64. PMID: 33667750 https://doi.org/10.1016/j.ajem.2021.02.013Miller R, Wagner S, Hammond J, Roberts N, Marshall K, Barth B. Posterior reversible encephalopathy syndrome in the emergency department: A single center retrospective study. Am J Emerg Med. 2021;45:61-64. PMID: 33667750 https://doi.org/10.1016/j.ajem.2021.02.013Сергеев А.В., Осипова В.В., Табеева Г.Р., Снопкова Е.В. Синдром обратимой церебральной вазоконстрикции. Неврологический журнал. 2012;17(3):4–11.Sergeev AV, Osipova VV, Tabeeva GR, Snopkova EV. The syndrome of reversible cerebral vasoconstriction. Nevrologicheskiy zhurnal. 2012;17(3):4–11. (In Russ.)de Havenon A, Joos Z, Longenecker L, Shah L, Ansari S, Digre K. Posterior reversible encephalopathy syndrome with spinal cord involvement. Neurology. 2014;83(22):2002–2006. PMID: 25355822 https://doi.org/10.1212/WNL.0000000000001026de Havenon A, Joos Z, Longenecker L, Shah L, Ansari S, Digre K. Posterior reversible encephalopathy syndrome with spinal cord involvement. Neurology. 2014;83(22):2002–2006. PMID: 25355822 https://doi.org/10.1212/WNL.0000000000001026Toledano M, Fugate JE. Posterior reversible encephalopathy in the intensive care unit. Handb Clin Neurol. 2017;141:467-483. PMID: 28190431 https://doi.org/10.1016/B978-0-444-63599-0.00026-0Toledano M, Fugate JE. Posterior reversible encephalopathy in the intensive care unit. Handb Clin Neurol. 2017;141:467-483. PMID: 28190431 https://doi.org/10.1016/B978-0-444-63599-0.00026-0Ahn KJ, You WJ, Jeong SL, Lee JW, Kim BS, Lee JH, et al. Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping. Neuroradiology. 2004;46(12):978–983. PMID: 15536557 https://doi.org/10.1007/s00234-004-1276-1Ahn KJ, You WJ, Jeong SL, Lee JW, Kim BS, Lee JH, et al. Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping. Neuroradiology. 2004;46(12):978–983. PMID: 15536557 https://doi.org/10.1007/s00234-004-1276-1Covarrubias DJ, Luetmer PH, Campeau NG. Posterior reversible encephalopathy syn drome: prognostic utility of quantitative diffusionweighted MR images. AJNR Am J Neuroradiol. 2002;23(6):1038-1048. PMID: 12063238Covarrubias DJ, Luetmer PH, Campeau NG. Posterior reversible encephalopathy syn drome: prognostic utility of quantitative diffusionweighted MR images. AJNR Am J Neuroradiol. 2002;23(6):1038-1048. PMID: 12063238Bartynski WS, Boardman JF. Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol. 2007;28(7):1320-1327. PMID: 17698535 https://doi.org/10.3174/ajnr.A0549Bartynski WS, Boardman JF. Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol. 2007;28(7):1320-1327. PMID: 17698535 https://doi.org/10.3174/ajnr.A0549Zou LP, Liu LY, Li H, Wang YY, Liu Y, Chen J, et al. Establishment and utility assessment of posterior reversible encephalopathy syndrome early warning scoring (PEWS) scale establishment and utility assessment of PEWS scale. BMC Neurol. 2019;19(1):30. PMID: 30791893 https://doi.org/10.1186/s12883-019-1247-0Zou LP, Liu LY, Li H, Wang YY, Liu Y, Chen J, et al. Establishment and utility assessment of posterior reversible encephalopathy syndrome early warning scoring (PEWS) scale establishment and utility assessment of PEWS scale. BMC Neurol. 2019;19(1):30. PMID: 30791893 https://doi.org/10.1186/s12883-019-1247-0Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953–2041. PMID: 30234752 https://doi.org/10.1097/HJH.0000000000001940Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953–2041. PMID: 30234752 https://doi.org/10.1097/HJH.0000000000001940Gasparini S, Ferlazzo E, Sueri C, Cianci V, Ascoli M, Cavalli SM, et al. Epilepsy Study Group of the Italian Neurological Society. Hypertension, seizures, and epilepsy: a review on pathophysiology and management. Neurol Sci. 2019;40(9):1775-1783. PMID: 31055731 https://doi.org/10.1007/s10072-019-03913-4Gasparini S, Ferlazzo E, Sueri C, Cianci V, Ascoli M, Cavalli SM, et al. Epilepsy Study Group of the Italian Neurological Society. Hypertension, seizures, and epilepsy: a review on pathophysiology and management. Neurol Sci. 2019;40(9):1775-1783. PMID: 31055731 https://doi.org/10.1007/s10072-019-03913-4Fittro K, Dizon R. Understanding posterior reversible encephalopathy syndrome. JAAPA. 2018;31(7):31-34. PMID: 29957604 https://doi.org/10.1097/01.JAA.0000534980.69236.81Fittro K, Dizon R. Understanding posterior reversible encephalopathy syndrome. JAAPA. 2018;31(7):31-34. PMID: 29957604 https://doi.org/10.1097/01.JAA.0000534980.69236.81Zeitouni D, Parish JM, Smith M, Stetler WR, Bernard JD. Reversible cerebral vasoconstriction syndrome successfully treated by intrathecal nicardipine. Clin Neurol Neurosurg. 2021;206:106705. PMID: 34053805 https://doi.org/10.1016/j.clineuro.2021.106705Zeitouni D, Parish JM, Smith M, Stetler WR, Bernard JD. Reversible cerebral vasoconstriction syndrome successfully treated by intrathecal nicardipine. Clin Neurol Neurosurg. 2021;206:106705. PMID: 34053805 https://doi.org/10.1016/j.clineuro.2021.106705Farid H, Tatum JK, Wong C, Halbach VV, Hetts SW. Reversible cerebral vasoconstriction syndrome: treatment with combined intra-arterial verapamil infusion and intracranial angioplasty. AJNR Am J Neuroradiol. 2011;32(10):E184-E187. PMID: 21273351 https://doi.org/10.3174/ajnr.A2341Farid H, Tatum JK, Wong C, Halbach VV, Hetts SW. Reversible cerebral vasoconstriction syndrome: treatment with combined intra-arterial verapamil infusion and intracranial angioplasty. AJNR Am J Neuroradiol. 2011;32(10):E184-E187. PMID: 21273351 https://doi.org/10.3174/ajnr.A2341Cai X, Bhattacharyya S, Plitt A, Raibagkar P, LaBuzetta JN, Schleicher SM, et al. Management of Posterior Reversible Syndrom Induced by Carbizomib in Patitnt with Multiple Myeloma. J Clin Oncol. 2016;34(2):e1-5. PMID: 24799479 https://doi.org/10.1200/JCO.2013.49.6166Cai X, Bhattacharyya S, Plitt A, Raibagkar P, LaBuzetta JN, Schleicher SM, et al. Management of Posterior Reversible Syndrom Induced by Carbizomib in Patitnt with Multiple Myeloma. J Clin Oncol. 2016;34(2):e1-5. PMID: 24799479 https://doi.org/10.1200/JCO.2013.49.6166Akins PT, Axelrod Y, Silverthorn JW, Guppy K, Banerjee A, Hawk MW. Management and outcomes of malignant posterior reversible encephalopathy syndrome. Clin Neurol Neurosurg. 2014;125:52–57. PMID: 25086431 https://doi.org/10.1016/j.clineuro.2014.06.034Akins PT, Axelrod Y, Silverthorn JW, Guppy K, Banerjee A, Hawk MW. Management and outcomes of malignant posterior reversible encephalopathy syndrome. Clin Neurol Neurosurg. 2014;125:52–57. PMID: 25086431 https://doi.org/10.1016/j.clineuro.2014.06.034Liman TG, Bohner G, Endres M, Siebert E. Discharge status and in-hospital mortality in posterior reversible encephalopathy syndrome. Acta Neurol Scand. 2014;130(1):34–39. PMID: 24329761 https://doi.org/10.1111/ane.12213Liman TG, Bohner G, Endres M, Siebert E. Discharge status and in-hospital mortality in posterior reversible encephalopathy syndrome. Acta Neurol Scand. 2014;130(1):34–39. PMID: 24329761 https://doi.org/10.1111/ane.12213

The authors declare that there are no conflicts of interest present.