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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2025.3.MORPH.2</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-1272</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Морфология, патология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Morphology, pathology</subject></subj-group></article-categories><title-group><article-title>Клинический случай комбинированного злокачественного новообразования шейки матки: нейроэндокринная карцинома и плоскоклеточный рак</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3343-6973</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаркуша</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Garkusha</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаркуша Татьяна Андреевна - Ассистент кафедры патологической анатомии им. профессора П.Г. Подзолкова; врач-патологоанатом Вклад автора: автор идеи, написание рабочего варианта рукописи, ответственность за целостность всех частей статьи, подготовка иллюстраций.</p><p>ул. Партизана-Железняка, д. 1, г. Красноярск, 660022;ул. Партизана-Железняка, д. 3Д, г. Красноярск, 660022</p></bio><bio xml:lang="en"><p>Tat'yana A. Garkusha - Assistant of the Department of Pathological Anatomy named after Professor P.G. Podzolkov; pathologist Author's contribution: author of the idea, writing the working version of the manuscript, responsibility for the integrity of all parts of the article, preparation of illustrations. </p><p>1, Partizana Zheleznyaka str., Krasnoyarsk, 660022;3D, Partizana Zheleznyaka str., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">t.garkusha@internet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-1132-2375</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загребельникова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagrebel'nikova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загребельникова Александра Николаевна - Студентка педиатрического факультета Вклад автора: написание рабочего варианта рукописи, ответственность за целостность всех частей статьи.</p><p>ул. Партизана-Железняка, д. 1, г. Красноярск, 660022</p></bio><bio xml:lang="en"><p>Aleksandra N. Zagrebel'nikova - Student of the Pediatrics Department Author's contribution: writing the working version of the manuscript, responsibility for the integrity of all parts of the article. </p><p>1, Partizana Zheleznyaka str., Krasnoyarsk, 660022</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-0675-9424</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелепова</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelepova</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шелепова Виктория Николаевна - Студентка педиатрического факультета Вклад автора: написание рабочего варианта рукописи, ответственность за целостность всех частей статьи.</p><p>ул. Партизана-Железняка, д. 1, г. Красноярск, 660022</p></bio><bio xml:lang="en"><p>Viktoriya N. Shelepova - Student of the Faculty of Pediatrics Author's contribution: writing the working version of the manuscript, responsibility for the integrity of all parts of the article. </p><p>1, Partizana Zheleznyaka str., Krasnoyarsk, 660022</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4438-1717</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алябьев</surname><given-names>Ф. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Alyab'ev</surname><given-names>F. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алябьев Федор Валерьевич - Д-р мед. наук, профессор, заведующий кафедры патологической анатомии им. профессора П.Г. Подзолкова, заведующий кафедры судебной медицины и ПО Вклад автора: научный консультант, редактирование текста статьи.</p><p>ул. Партизана-Железняка, д. 1, г. Красноярск, 660022</p></bio><bio xml:lang="en"><p>Fedor V. Alyab'yev - Dr. Cand. Sci. (Med.), Professor, Head of the Department of Pathological Anatomy named after Professor P.G. Podzolkov, Head of the Department of Forensic Medicine and PO Author's contribution: scientific consultant, editing the text of the article. </p><p>1, Partizana Zheleznyaka str., Krasnoyarsk, 660022</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хлуднева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khludneva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хлуднева Наталья Владимировна - Канд. мед. наук, доцент, кафедры судебной медицины и ПО Вклад автора: научный консультант, редактирование текста статьи.</p><p>ул. Партизана-Железняка, д. 1, г. Красноярск, 660022</p></bio><bio xml:lang="en"><p>Natal'ya V. Khludneva - Cand. Sci. (Med.), Docent, department of forensic medicine and PO Author's contribution: scientific consultant, editing the text of the article. </p><p>1, Partizana Zheleznyaka str., Krasnoyarsk, 660022</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого;&#13;
Красноярское краевое патологоанатомическое бюро<country>Россия</country></aff><aff xml:lang="en">Krasnoyarsk State Medical University named after Professor V. F. Voyno-Yasenetsky;&#13;
Krasnoyarsk Regional Pathological Anatomy Bureau<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого<country>Россия</country></aff><aff xml:lang="en">Krasnoyarsk State Medical University named after Professor V. F. Voyno-Yasenetsky<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>01</day><month>08</month><year>2025</year></pub-date><volume>15</volume><issue>3</issue><fpage>151</fpage><lpage>155</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гаркуша Т.А., Загребельникова А.Н., Шелепова В.Н., Алябьев Ф.В., Хлуднева Н.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гаркуша Т.А., Загребельникова А.Н., Шелепова В.Н., Алябьев Ф.В., Хлуднева Н.В.</copyright-holder><copyright-holder xml:lang="en">Garkusha T.A., Zagrebel'nikova A.N., Shelepova V.N., Alyab'ev F.V., Khludneva N.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/1272">https://vestnik.reaviz.ru/jour/article/view/1272</self-uri><abstract><p>Нейроэндокринные карциномы являются редкими и агрессивными типами опухолей шейки матки. В доступной литературе мало описано случаев смешанной нейроэндокринной и плоскоклеточной карциномы, и знания о таком типе смешанной карциномы ограничены. Морфологическая диагностика этого типа карцином бывает затруднена вследствие того, что клетки нейроэндокринной карциномы могут напоминать плоскоклеточную карциному. Дополнительные сложности могут быть вызваны отсутствием экспрессии части специфических нейроэндокринных маркеров. Неверная диагностика данной карциномы может приводить к неправильной тактике ведения пациента или её отсрочке. В данной статье представлено клиническое наблюдение пациентки 45 лет, у которой была диагностирована смешанная нейроэндокринная и плоскоклеточная карцинома шейки матки, ВПЧ-ассоциированная, с множественными метастазами. Данный случай представляет интерес в связи с редкостью этой патологии и сложностью её диагностики.</p></abstract><trans-abstract xml:lang="en"><p>Neuroendocrine carcinomas are rare and aggressive types of cervical tumors. Available literature contains limited descriptions of mixed carcinomas, and knowledge about this type of mixed carcinoma remains limited. Morphological diagnosis of this carcinoma type can be difficult due to the fact that neuroendocrine carcinoma cells can resemble squamous cell carcinoma. Additional complications can be caused by the lack of expression of some specific neuroendocrine markers. Incorrect diagnosis of this carcinoma can lead to incorrect patient management tactics or treatment delays. This article presents a clinical observation of a 45-year-old female patient who was diagnosed with mixed neuroendocrine and squamous cell carcinoma of the cervix, HPV-associated, with multiple metastases. This case is of particular interest due to the rarity of this pathology and diagnostics challenges it presents.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>злокачественное новообразование [C04.557]</kwd><kwd>смешанная карцинома [C04.557.470.200.025]</kwd><kwd>карцинома шейки матки [C04.588.322.894]</kwd><kwd>нейроэндокринная карцинома [C04.557.470.200.025.330]</kwd><kwd>плоскоклеточная карцинома [C04.557.470.200.025.700]</kwd><kwd>вирус папилломы человека [C02.256.743]</kwd><kwd>метастазы [C04.697.645]</kwd><kwd>иммуногистохимия [E01.370.225.500.384.100]</kwd><kwd>морфологическая диагностика [H02.403.670]</kwd><kwd>клинический случай [V02.600.300.200]</kwd></kwd-group><kwd-group xml:lang="en"><kwd>malignant neoplasm / Neoplasms</kwd><kwd>Malignant [C04.557]</kwd><kwd>mixed carcinoma / Carcinoma [C04.557.470.200.025]</kwd><kwd>cervical carcinoma / Uterine Cervical Neoplasms [C04.588.322.894]</kwd><kwd>neuroendocrine carcinoma / Carcinoma</kwd><kwd>Neuroendocrine [C04.557.470.200.025.330]</kwd><kwd>squamous cell carcinoma / Carcinoma</kwd><kwd>Squamous Cell [C04.557.470.200.025.700]</kwd><kwd>human papillomavirus / Papillomavirus Infections [C02.256.743]</kwd><kwd>metastases / Neoplasm Metastasis [C04.697.645]</kwd><kwd>immunohistochemistry [E01.370.225.500.384.100]</kwd><kwd>morphological diagnosis / Pathology</kwd><kwd>Clinical [H02.403.670]</kwd><kwd>clinical case / Case Reports [V02.600.300.200]</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">TempferCB, TischoffI, DoganA, HilalZ, SchultheisB, KernP et al. 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