vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2025.4.DENT.1vmireaviz-1291Research ArticleВопросы стоматологииDentistryСовременные возможности и перспективы мезенхимальных стволовых клеток в ортопедической стоматологии (обзор литературы)Modern possibilities and prospects of mesenchymal stem cells in orthopedic dentistry (literature review)https://orcid.org/0009-0007-9171-2554МусаеваХ. Х.MusaevaH. H.

Мусаева Ханифа Хамди гызы, Канд. мед. наук, ассистент кафедры ортопедической стоматологии Вклад автора: подбор и анализ литературы, написание текста статьи.

ул. Бакиханова, д. 23, г. Баку,

Hanifa Hamdi gizi Musaeva, Cand. Sci. (Med.), Assistant of the Department of Prosthetic Dentistry Author's contribution: selection and analysis of literature, writing the article.

Bakikhanov str., 23, Baku

Азербайджанский Медицинский УниверситетАзербайджанAzerbaijan Medical UniversityAzerbaijan202528102025154214220Copyright © Мусаева Х.Х., 20252025Мусаева Х.Х.Musaeva H.H.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/1291

В обзорной статье представлены результаты анализа современных литературных источников, посвящённых получению и применению мезенхимальным стволовым клеткам (МСК) в ортопедической стоматологии. В статье рассмотрены основные типы дентальных МСК – стволовые клетки пульпы зуба (DPSC), стволовые клетки отслоившихся молочных зубов (SHED), стволовые клетки апикального сосочка (SCAP), клетки пародонтальной связки (PDLSC) – их происхождение, молекулярно-биологические характеристики, дифференцировочный потенциал и возможности применения в тканевой инженерии. Обобщены данные о секреторной активности МСК, их иммуномодулирующих и регенеративных свойствах. Подчёркнута высокая перспективность применения дентальных МСК в реконструкции твёрдых и мягких тканей полости рта, в том числе при адентии, как альтернатива или дополнение к традиционным методам лечения.

The review article presents the results of an analysis of modern literature sources dedicated to the isolation and application of mesenchymal stem cells (MSCs) in prosthetic dentistry. The article discusses the main types of dental MSCs — dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from the apical papilla (SCAP), and periodontal ligament stem cells (PDLSCs) — focusing on their origin, molecular and biological characteristics, differentiation potential, and possible applications in tissue engineering. The data on the secretory activity of MSCs, their immunomodulatory and regenerative properties are summarized. The high potential of dental MSCs in the reconstruction of hard and soft oral tissues, including in cases of edentulism, is emphasized, highlighting their role as an alternative or adjunct to conventional treatment methods.

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The authors declare that there are no conflicts of interest present.