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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2025.6.MIM.2</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-1338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНСКАЯ ВИЗУАЛИЗАЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL IMAGING</subject></subj-group></article-categories><title-group><article-title>Оценка морфометрических параметров теменных долей головного мозга у детей при магнитно-резонансном исследовании</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of morphometric parameters of the parietal lobes in children using magnetic resonance imaging</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0034-7413</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семибратов</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Semibratov</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семибратов Николай Николаевич. Врач-рентгенолог отделения амбулаторного лечения с дневным стационаром в составе радиотерапевтического отделения; ассистент кафедры онкологии, детской онкологии и лучевой терапии</p><p>Ленинградская ул., д. 68А, пос. Песочный, г. Санкт-Петербург, 197758</p><p>ул. Литовская, д. 2, г. Санкт-Петербург, 194100</p></bio><bio xml:lang="en"><p>Nikolay N. Semibratov. Radiologist, Outpatient Treatment Department with Day Hospital, Radiotherapy Department; Assistant Professor, Department of Oncology, Pediatric Oncology, and Radiation Therapy</p><p>Leningradskaya str., 68a, vill. Pesochniy, St. Petersburg, 197758</p><p>Litovskaya str., 2, St. Petersburg 194100</p></bio><email xlink:type="simple">nsemibr@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7885-9024</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фокин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fokin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фокин Владимир Александрович. Д-р мед. наук, профессор кафедры лучевой диагностики и медицинской визуализации</p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Vladimir A. Fokin. Dr. Sci. (Med.), Professor of the Department of Radiation Diagnostics and Medical Imaging</p><p>Akkuratova str., 2, St. Petersburg, 197341</p><p> </p></bio><email xlink:type="simple">vladfokin@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1611-5000</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Труфанов</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Trufanov</surname><given-names>G. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Труфанов Геннадий Евгеньевич. Д-р мед. наук, профессор, заведующий кафедрой лучевой диагностики и медицинской визуализации</p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Gennadiy E. Trufanov. Dr. Sci. (Med.), Professor, Head of the Department of Radiation Diagnostics and Medical Imaging</p><p>Akkuratova str., 2, St. Petersburg, 197341</p></bio><email xlink:type="simple">trufanovge@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2249-1405</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефимцев</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Efimtsev</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефимцев Александр Юрьевич. Д-р мед. наук, профессор кафедры лучевой диагностики и медицинской визуализации, ведущий научный сотрудник НИЛ лучевой визуализации</p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Aleksandr Yu. Efimtsev. Dr. Sci. (Med.), Professor of the Department of Radiation Diagnostics and Medical Imaging, Leading Researcher at the Research Laboratory of Radiation Imaging</p><p>Akkuratova str., 2, St. Petersburg, 197341</p></bio><email xlink:type="simple">atralf@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1290-3659</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамов</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramov</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абрамов Константин Борисович. Канд. мед. наук, заместитель главного врача, врач-нейрохирург Российского научно-исследовательского нейрохирургического института им. проф. А.Л. Поленова – филиала </p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Konstantin B. Abramov. Cand. Sci. (Med.), Deputy Chief Physician, Neurosurgeon, Russian Research Neurosurgical Institute named after Professor A.L. Polenov, a branch </p><p>Akkuratova str., 2, St. Petersburg, 197341</p></bio><email xlink:type="simple">kalyghanin@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1462-6907</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондратьев</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondratiev</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кондратьев Глеб Валентинович. Ассистент кафедры онкологии, детской онкологии и лучевой терапии, врач-детский онколог</p><p>ул. Литовская, д. 2, г. Санкт-Петербург, 194100</p></bio><bio xml:lang="en"><p>Gleb V. Kondrat'ev. Assistant Professor, Department of Oncology, Pediatric Oncology, and Radiation Therapy; Pediatric Oncologist</p><p> </p></bio><email xlink:type="simple">spbgvk@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8848-3136</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левчук</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Levchuk</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Левчук Анатолий Геннадьевич. Младший научный сотрудник НИЛ магнитно-резонансной томографии</p><p>ул. Аккуратова, д. 2, г. Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Anatoliy G. Levchuk. Junior Researcher, Magnetic Resonance Imaging Research Laboratory</p><p>Akkuratova str., 2, St. Petersburg, 197341</p></bio><email xlink:type="simple">feuerlag999@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический) имени Н.П. Напалкова; Санкт-Петербургский государственный педиатрический медицинский университет</aff><aff xml:lang="en">N.P. Napalkov St. Petersburg Clinical Scientific and Practical Center for Specialized Medical Care (Oncology); Saint Petersburg State Pediatric Medical University</aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Национальный медицинский исследовательский центр им. В.А. Алмазова<country>Россия</country></aff><aff xml:lang="en">Almazov National Medical Research Centre<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Санкт-Петербургский государственный педиатрический медицинский университет<country>Россия</country></aff><aff xml:lang="en">Saint Petersburg State Pediatric Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>10</day><month>03</month><year>2026</year></pub-date><volume>15</volume><issue>6</issue><fpage>304</fpage><lpage>313</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Семибратов Н.Н., Фокин В.А., Труфанов Г.Е., Ефимцев А.Ю., Абрамов К.Б., Кондратьев Г.В., Левчук А.Г., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Семибратов Н.Н., Фокин В.А., Труфанов Г.Е., Ефимцев А.Ю., Абрамов К.Б., Кондратьев Г.В., Левчук А.Г.</copyright-holder><copyright-holder xml:lang="en">Semibratov N.N., Fokin V.A., Trufanov G.E., Efimtsev A.Y., Abramov K.B., Kondratiev G.V., Levchuk A.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/1338">https://vestnik.reaviz.ru/jour/article/view/1338</self-uri><abstract><sec><title>Введение</title><p>Введение. Настоящее исследование посвящено количественному анализу теменных долей головного мозга у детей с использованием магнитно-резонансной морфометрии. Теменные доли играют ключевую роль в восприятии тактильной информации, пространственной ориентации тела и регуляции целенаправленных движений. В раннем детском возрасте, когда происходит интенсивное развитие мозга, теменные доли претерпевают значительные структурные изменения, что обосновывает необходимость проведения подробного морфометрического исследования. Полученные данные способствуют углублению знаний о нормальном развитии нервной системы и повышению точности диагностики патологий, ассоциированных с аномалиями строения теменных долей, такими как синдром дефицита внимания и гиперактивности, аутизм, эпилепсия и когнитивные расстройства.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: изучение морфометрических показателей структур теменных долей головного мозга у неврологически здоровых детей с целью выявления возрастных и половых различий.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Всего обследовано 49 детей в возрасте от 2 месяцев до 18 лет. Наблюдения были разделены на две группы: от рождения до 7 лет (17 человек), от 7 до 18 лет (32 человека). Морфометрический анализ теменных долей головного мозга выполнен с использованием программного обеспечения «FreeSurfer», в ходе которого были проанализированы следующие параметры: объём для каждой структуры теменных долей, площадь поверхности и толщина коры.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе исследования были обнаружены возрастные изменения объёма, площади и толщины коры различных структур теменной доли у детей. Хотя статистически значимых гендерных различий в морфометрических показателях этих структур не выявлено, наблюдалась тенденция к увеличению относительных размеров (рассчитанных относительно внутричерепного объёма) у мальчиков по сравнению с девочками. Полученные данные свидетельствуют о сложной и разнонаправленной динамике развития теменной доли в онтогенезе, проявляющейся как симметричных, так и в асимметричных изменениях.</p></sec><sec><title>Заключение</title><p>Заключение. Настоящее исследование демонстрирует эффективность магнитнорезонансной морфометрии в анализе развития структур теменных долей у неврологически здоровых детей. Полученные морфометрические показатели могут быть использованы в качестве сравнительных референсных данных при исследовании структурных изменений при различных неврологических состояниях. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. This study is dedicated to the quantitative analysis of the parietal lobes in the pediatric brain using magnetic resonance morphometry. The parietal lobes play a key role in tactile perception, spatial body orientation, and the regulation of goal-directed movements. In early childhood, a period marked by intensive brain development, the parietal lobes undergo significant structural changes, which justifies the need for detailed morphometric analysis. The obtained data contribute to a deeper understanding of normal nervous system development and improve the accuracy of diagnosing pathologies associated with structural abnormalities of the parietal lobes, such as attention deficit hyperactivity disorder, autism spectrum disorder, epilepsy, and cognitive impairments.</p></sec><sec><title>Aim</title><p>Aim. To perform a detailed study of morphometric parameters of the parietal lobe brain structures in neurologically healthy children to identify age- and gender-related variations.</p></sec><sec><title>Methods</title><p>Methods. The study included 49 children aged between 2 months and 18 years. All observations were divided into two age groups: from birth to 7 years (17 subjects) and from 7 to 18 years (32 subjects). Morphometric analysis of the parietal lobes was performed using the FreeSurfer software, the following parameters were analyzed: volume of each parietal lobe structure, surface area, and cortical thickness.</p></sec><sec><title>Results</title><p>Results. Age-related changes in the volume, surface area, and cortical thickness of various parietal lobe structures were identified. Although no statistically significant gender differences in the morphometric parameters of these structures were found, there was a tendency for increased relative sizes (normalized to intracranial volume) in boys compared to girls. The data indicate complex and heterogeneous developmental dynamics of the parietal lobe during ontogenesis, manifested in both symmetrical and asymmetrical changes.</p></sec><sec><title>Conclusion</title><p>Conclusion. This study demonstrates the effectiveness of using morphometry for analyzing the development of parietal lobe structures in neurologically healthy children. The obtained morphometric measures may serve as comparative reference data for studies of structural changes in various neurological conditions. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>магнитно-резонансная томография [D008279]</kwd><kwd>магнитно-резонансная морфометрия [D059906 (Neuroimaging)]</kwd><kwd>теменная доля /[D010296]</kwd><kwd>дети [D002648]</kwd><kwd>рост и развитие [D006128 (Growth and Development)]</kwd><kwd>головной мозг [D001921]</kwd><kwd>возрастные изменения [D000375 (Age Factors)]</kwd><kwd>кора головного мозга [D002540]</kwd><kwd>нейровизуализация [D059906]</kwd><kwd>морфометрия [D009682 (Anatomy)]</kwd></kwd-group><kwd-group xml:lang="en"><kwd>magnetic resonance imaging [D008279]</kwd><kwd>magnetic resonance morphometry [D059906 (Neuroimaging)]</kwd><kwd>parietal lobe [D010296]</kwd><kwd>children [D002648]</kwd><kwd>growth and development [D006128 (Growth and Development)]</kwd><kwd>brain [D001921]</kwd><kwd>age-related changes [D000375 (Age Factors)]</kwd><kwd>cerebral cortex [D002540]</kwd><kwd>neuroimaging [D059906]</kwd><kwd>morphometry [D009682 (Anatomy)]</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сидорова И.С., Никитина Н.А., Унанян А.Л., Агеев М.Б. Развитие головного мозга плода и влияние пренатальных повреждающих факторов на основные этапы нейрогенеза. Российский вестник акушера-гинеколога. 2022;22(1):35–44. https://doi.org/10.17116/rosakush20222201135</mixed-citation><mixed-citation xml:lang="en">1 Sidorova I.S., Nikitina N.A., Unanyan A.L., Ageev M.B. Development of the human fetal brain and the influence of prenatal damaging factors on the main stages of neurogenesis. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(1):35–44. (In Russ.) https://doi.org/10.17116/rosakush20222201135</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Giedd J.N., Castellanos F.X., Rajapakse J.C., Vaituzis A.C., Rapoport J.L. Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry. 1997;21(8):1185–1201. PMID: 9460086 https://doi.org/10.1016/s0278-5846(97)00158-9</mixed-citation><mixed-citation xml:lang="en">2 Giedd J.N., Castellanos F.X., Rajapakse J.C., Vaituzis A.C., Rapoport J.L. Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry. 1997;21(8):1185–1201. PMID: 9460086 https://doi.org/10.1016/s0278-5846(97)00158-9</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lenroot R.K., Gogtay N., Greenstein D.K., Wells E.M., Wallace G.L., Clasen L.S., et al. Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage. 2007;36(4):1065–1073. PMID: 17513132 https://doi.org/10.1016/j.neuroimage.2007.03.053</mixed-citation><mixed-citation xml:lang="en">3 Lenroot R.K., Gogtay N., Greenstein D.K., Wells E.M., Wallace G.L., Clasen L.S., et al. Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage. 2007;36(4):1065–1073. PMID: 17513132 https://doi.org/10.1016/j.neuroimage.2007.03.053</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sowell E.R., Trauner D.A., Gamst A., Jernigan T.L. Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study. Dev Med Child Neurol. 2002;44(1):4–16. PMID: 11811649 https://doi.org/10.1017/s0012162201001591</mixed-citation><mixed-citation xml:lang="en">4 Sowell E.R., Trauner D.A., Gamst A., Jernigan T.L. Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study. Dev Med Child Neurol. 2002;44(1):4–16. PMID: 11811649 https://doi.org/10.1017/s0012162201001591</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wilke M., Schmithorst V.J., Holland, S.K. Assessment of spatial normalization of whole-brain magnetic resonance images in children. Human brain mapping. 2002;17(1):48–60. PMID: 12203688 https://doi.org/10.1002/hbm.10053</mixed-citation><mixed-citation xml:lang="en">5 Wilke M., Schmithorst V.J., Holland, S.K. Assessment of spatial normalization of whole-brain magnetic resonance images in children. Human brain mapping. 2002;17(1):48–60. PMID: 12203688 https://doi.org/10.1002/hbm.10053</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Воронова Н.В., Климова Н.М., Менджерицкий А.М. Анатомия центральной нервной системы. Москва: Аспект Пресс; 2005.</mixed-citation><mixed-citation xml:lang="en">6 Voronova N.V., Klimova N.M., Mendgeritsky A.M. Anatomy of the Central Nervous System. Moscow: Aspect Press; 2005. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Giedd J.N., Blumenthal J., Jeffries N.O., Castellanos F.X., Liu H., Zijdenbos A., et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci. 1999;2(10):861–863. PMID: 10491603 https://doi.org/10.1038/13158</mixed-citation><mixed-citation xml:lang="en">7 Giedd J.N., Blumenthal J., Jeffries N.O., Castellanos F.X., Liu H., Zijdenbos A., et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci. 1999;2(10):861–863. PMID: 10491603 https://doi.org/10.1038/13158</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jernigan T.L., Tallal P. Late childhood changes in brain morphology observable with MRI. Dev Med Child Neurol. 1990;32(5):379–385. PMID: 2354751 https://doi.org/10.1111/j.1469-8749.1990.tb16956.x</mixed-citation><mixed-citation xml:lang="en">8 Jernigan T.L., Tallal P. Late childhood changes in brain morphology observable with MRI. Dev Med Child Neurol. 1990;32(5):379–385. PMID: 2354751 https://doi.org/10.1111/j.1469-8749.1990.tb16956.x</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pfefferbaum A., Mathalon D.H., Sullivan E.V., Rawles J.M., Zipursky R.B., Lim K.O. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol. 1994;51(9):874–887. PMID: 8080387 https://doi.org/10.1001/archneur.1994.00540210046012</mixed-citation><mixed-citation xml:lang="en">9 Pfefferbaum A., Mathalon D.H., Sullivan E.V., Rawles J.M., Zipursky R.B., Lim K.O. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol. 1994;51(9):874–887. PMID: 8080387 https://doi.org/10.1001/archneur.1994.00540210046012</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Vijayakumar N., Allen N.B., Youssef G., Dennison M., Yücel M., Simmons J.G., et al. Brain development during adolescence: A mixedlongitudinal investigation of cortical thickness, surface area, and volume. Hum Brain Mapp. 2016;37:2027–2038. PMID: 26946457 https://doi.org/10.1002/hbm.23154</mixed-citation><mixed-citation xml:lang="en">10 Vijayakumar N., Allen N.B., Youssef G., Dennison M., Yücel M., Simmons J.G., et al. Brain development during adolescence: A mixedlongitudinal investigation of cortical thickness, surface area, and volume. Hum Brain Mapp. 2016;37:2027–2038. PMID: 26946457 https://doi.org/10.1002/hbm.23154</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sowell E.R., Thompson P.M., Holmes C.J., Batth R., Jernigan T.L., Toga A.W. Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. Neuroimage. 1999;9(6Pt1):587–597. PMID: 10334902 https://doi.org/10.1006/nimg.1999.0436</mixed-citation><mixed-citation xml:lang="en">11 Sowell E.R., Thompson P.M., Holmes C.J., Batth R., Jernigan T.L., Toga A.W. Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. Neuroimage. 1999;9(6Pt1):587–597. PMID: 10334902 https://doi.org/10.1006/nimg.1999.0436</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rakic P, Ayoub A.E., Breunig J.J., Dominguez M.H. Decision by division: making cortical maps. Trends in neurosciences. 2009;32(5):291–301. PMID: 19380167 https://doi.org/10.1016/j.tins.2009.01.007</mixed-citation><mixed-citation xml:lang="en">12 Rakic P, Ayoub A.E., Breunig J.J., Dominguez M.H. Decision by division: making cortical maps. Trends in neurosciences. 2009;32(5):291–301. PMID: 19380167 https://doi.org/10.1016/j.tins.2009.01.007</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Горчаков В.Н., Сергеева И.Г., Тулупов А.А. Нейрохирургическая анатомия головного мозга. Новосибирск: НГУ; 2015.</mixed-citation><mixed-citation xml:lang="en">13 Gorchakov V.N., Sergeeva I.G., Tulupov A.A. Neurosurgical Anatomy of the Brain. Novosibirsk: NSU; 2015. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Байбаков С.Е., Бахарева Н.С., Гордеева Е.К., Бараева Л.М., Хромов Д.А., Юсупова А.И. и др. Динамика роста полушарий головного мозга и его долей у детей периода раннего детства. Международный научно-исследовательский журнал. 2024;150(12).https://doi.org/10.60797/IRJ.2024.150.13</mixed-citation><mixed-citation xml:lang="en">14 Baibakov S.E., Bakhareva N.S., Gordeeva E.K., Baraeva L.M., Khromov D.A., Yusupova A.I., et al. Dynamics of growth of cerebral hemispheres and their lobes in children of early childhood period. International Research Journal. 2024;150(12). (In Russ.) https://doi.org/10.60797/IRJ.2024.150.13</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Потемкина Е.Г., Саломатина Т.А., Андреев Е.В., Абрамов К.Б., Банникова В.Д., Деньгина Н.О. и др. Применение МР-морфометрии в эпилептологии: достижения и перспективы. Вопросы нейрохирургии имени Н.Н. Бурденко. 2023;87(3):113–119. PMID: 37325834 https://doi.org/10.17116/neiro202387031113 Backhausen L.L., Herting M.M., Tamnes C.K., Vetter N.C. Best Practices in Structural Neuroimaging of Neurodevelopmental Disorders. Neuropsychol Rev. 2022;32(2):400–418. PMID: 33893904 https://doi.org/10.1007/s11065-021-09496-2</mixed-citation><mixed-citation xml:lang="en">15 Potemkina E.G., Salomatina T.A., Andreev E.V., Abramov K.B., Bannikova V.D., Dengina N.O., et al. MR morphometry in epileptology: progress and perspectives. Burdenko's Journal of Neurosurgery. 2023;87(3):113–119. (In Russ.) PMID: 37325834 https://doi.org/10.17116/neiro202387031113 Backhausen L.L., Herting M.M., Tamnes C.K., Vetter N.C. Best Practices in Structural Neuroimaging of Neurodevelopmental Disorders. Neuropsychol Rev. 2022;32(2):400–418. PMID: 33893904 https://doi.org/10.1007/s11065-021-09496-2</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fjell A.M., Walhovd K.B. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187–221. PMID: 20879692 https://doi.org/10.1515/revneuro.2010.21.3.187</mixed-citation><mixed-citation xml:lang="en">16 Fjell A.M., Walhovd K.B. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187–221. PMID: 20879692 https://doi.org/10.1515/revneuro.2010.21.3.187</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Heinen R., Bouvy W.H., Mendrik A.M., Viergever M.A., Biessels G.J., de Bresser J. Robustness of Automated Methods for Brain Volume Measurements across Different MRI Field Strengths. PLoS One. 2016;11(10):e0165719. PMID: 27798694 https://doi.org/10.1371/journal.pone.0165719</mixed-citation><mixed-citation xml:lang="en">17 Heinen R., Bouvy W.H., Mendrik A.M., Viergever M.A., Biessels G.J., de Bresser J. Robustness of Automated Methods for Brain Volume Measurements across Different MRI Field Strengths. PLoS One. 2016;11(10):e0165719. PMID: 27798694 https://doi.org/10.1371/journal.pone.0165719</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fischl B. FreeSurfer. Neuroimage. 2012;62(2):774–781. PMID: 22248573 https://doi.org/10.1016/j.neuroimage.2012.01.021</mixed-citation><mixed-citation xml:lang="en">18 Fischl B. FreeSurfer. Neuroimage. 2012;62(2):774–781. PMID: 22248573 https://doi.org/10.1016/j.neuroimage.2012.01.021</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Fischl, B., Salat D.H., Busa E., Albert M., Dieterich M., Haselgrove C., et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33(3):341–355. PMID: 11832223 https://doi.org/10.1016/s0896-6273(02)00569-x</mixed-citation><mixed-citation xml:lang="en">19 Fischl, B., Salat D.H., Busa E., Albert M., Dieterich M., Haselgrove C., et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33(3):341–355. PMID: 11832223 https://doi.org/10.1016/s0896-6273(02)00569-x</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fischl B., Sereno M.I., Dale A.M. Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage. 1999;9(2):195–207. PMID: 9931269 https://doi.org/10.1006/nimg.1998.0396</mixed-citation><mixed-citation xml:lang="en">20 Fischl B., Sereno M.I., Dale A.M. Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage. 1999;9(2):195–207. PMID: 9931269 https://doi.org/10.1006/nimg.1998.0396</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Klein A., Tourville J. 101 Labeled Brain Images and a Consistent Human Cortical Labeling Protocol. Front Neurosci. 2012;6. PMID: 23227001 https://doi.org/10.3389/fnins.2012.00171</mixed-citation><mixed-citation xml:lang="en">21 Klein A., Tourville J. 101 Labeled Brain Images and a Consistent Human Cortical Labeling Protocol. Front Neurosci. 2012;6. PMID: 23227001 https://doi.org/10.3389/fnins.2012.00171</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">The jamovi project. jamovi. Version 2.5 [Computer Software] — [cited 2025 Sep 10]. Available from: https://www.jamovi.org</mixed-citation><mixed-citation xml:lang="en">22 The jamovi project. jamovi. Version 2.5 [Computer Software] — [cited 2025 Sep 10]. Available from: https://www.jamovi.org</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Microsoft Corporation. Microsoft Excel. Version 16.88 [Computer Software]. — [cited 2025 Sep 10]. Available from: https://www.microsoft.com</mixed-citation><mixed-citation xml:lang="en">23 Microsoft Corporation. Microsoft Excel. Version 16.88 [Computer Software]. — [cited 2025 Sep 10]. Available from: https://www.microsoft.com</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Herting M.M., Johnson C., Mills K.L., Vijayakumar N., Dennison M., Liu C., et al. Development of subcortical volumes across adolescence in males and females: A multisample study of longitudinal changes. Neuroimage. 2018;172:194–205. PMID: 29353072 https://doi.org/10.1016/j.neuroimage.2018.01.020</mixed-citation><mixed-citation xml:lang="en">24 Herting M.M., Johnson C., Mills K.L., Vijayakumar N., Dennison M., Liu C., et al. Development of subcortical volumes across adolescence in males and females: A multisample study of longitudinal changes. Neuroimage. 2018;172:194–205. PMID: 29353072 https://doi.org/10.1016/j.neuroimage.2018.01.020</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Tamnes C.K., Herting M.M., Goddings A.L., Meuwese R., Blakemore S.J., Dahl R.E, et al. Development of the Cerebral Cortex across Adolescence: A Multisample Study of Inter-Related Longitudinal Changes in Cortical Volume, Surface Area, and Thickness. J Neurosci. 2017;37(12):3402–3412. PMID: 28242797 https://doi.org/10.1523/JNEUROSCI.3302-16.2017</mixed-citation><mixed-citation xml:lang="en">25 Tamnes C.K., Herting M.M., Goddings A.L., Meuwese R., Blakemore S.J., Dahl R.E, et al. Development of the Cerebral Cortex across Adolescence: A Multisample Study of Inter-Related Longitudinal Changes in Cortical Volume, Surface Area, and Thickness. J Neurosci. 2017;37(12):3402–3412. PMID: 28242797 https://doi.org/10.1523/JNEUROSCI.3302-16.2017</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Leonard C.M., Towler S., Welcome S., Halderman L.K., Otto R., Eckert M.A., et al. Size matters: cerebral volume influences sex differences in neuroanatomy. Cerebral cortex. 2008;18(12):2920–2931. PMID: 18440950 https://doi.org/10.1093/cercor/bhn052</mixed-citation><mixed-citation xml:lang="en">26 Leonard C.M., Towler S., Welcome S., Halderman L.K., Otto R., Eckert M.A., et al. Size matters: cerebral volume influences sex differences in neuroanatomy. Cerebral cortex. 2008;18(12):2920–2931. PMID: 18440950 https://doi.org/10.1093/cercor/bhn052</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Luders E., Gaser C., Narr K.L., Toga A.W. Why sex matters: brain size independent differences in gray matter distributions between men and women. J Neurosci. 2009;29(45):14265–14270. PMID: 19906974 https://doi.org/10.1523/JNEUROSCI.2261-09.2009</mixed-citation><mixed-citation xml:lang="en">27 Luders E., Gaser C., Narr K.L., Toga A.W. Why sex matters: brain size independent differences in gray matter distributions between men and women. J Neurosci. 2009;29(45):14265–14270. PMID: 19906974 https://doi.org/10.1523/JNEUROSCI.2261-09.2009</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Lenroot R.K., Giedd J.N. Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neurosci Biobehav Rev. 2006;30(6):718–729. PMID: 16887188 https://doi.org/10.1016/j.neubiorev.2006.06.001</mixed-citation><mixed-citation xml:lang="en">28 Lenroot R.K., Giedd J.N. Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neurosci Biobehav Rev. 2006;30(6):718–729. PMID: 16887188 https://doi.org/10.1016/j.neubiorev.2006.06.001</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Sullivan E.V., Rosenbloom M., Serventi K.L., Pfefferbaum A. Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging. 2004;25(2):185–192. PMID: 14749136 https://doi.org/10.1016/s0197-4580(03)00044-7</mixed-citation><mixed-citation xml:lang="en">29 Sullivan E.V., Rosenbloom M., Serventi K.L., Pfefferbaum A. Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging. 2004;25(2):185–192. PMID: 14749136 https://doi.org/10.1016/s0197-4580(03)00044-7</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Resnick S.M., Goldszal A.F., Davatzikos C., Golski S., Kraut M.A., Metter E.J., et. al. One-year age changes in MRI brain volumes in older adults. Cereb Cortex. 2000;10(5):464–472. PMID: 10847596 https://doi.org/10.1093/cercor/10.5.464</mixed-citation><mixed-citation xml:lang="en">30 Resnick S.M., Goldszal A.F., Davatzikos C., Golski S., Kraut M.A., Metter E.J., et. al. One-year age changes in MRI brain volumes in older adults. Cereb Cortex. 2000;10(5):464–472. PMID: 10847596 https://doi.org/10.1093/cercor/10.5.464</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Полунина А.Г., Брюн Е.А. Нейроанатомические особенности головного мозга у мужчин и женщин. Анналы клинической и экспериментальной неврологии. 2017;3(11):68–75.</mixed-citation><mixed-citation xml:lang="en">31 Polunina A.G., Bryun, E. A. Neuroanatomic differences of the brain in males and females. Annals Of Clinical and Experimental Neurology. 2017;11(3):68–75. https://doi.org/10.17816/ACEN.2017.3.10</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
