vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2026.3.MIM.1vmireaviz-1366Research ArticleМедицинская визуализацияMedical ImagingАнализ рисков развития поражения базальных ганглиев и таламуса как наиболее значимых признаков тяжелого гипоксически-ишемического поражения головного мозгаAnalysis of the risks of developing damage to the basal ganglia and thalamus as the most significant signs of severe hypoxic-ischemic brain damagehttps://orcid.org/0000-0002-0625-1404СоколовП. Л.SokolovP. L.

Соколов Павел Леонидович - Д-р мед. наук, ведущий научный сотрудник

ул. Авиаторов, д. 38, г. Москва, 119620, Россия

Pavel L. Sokolov - Dr. Sci. (Med.), Leading Researcher

 

psok.sci@gmail.comhttps://orcid.org/0000-0002-1898-7769РомановП. А.RomanovP. A.

Романов Павел Анатольевич - Заведующий отделением лучевой диагностики

ул. Авиаторов, д. 38, г. Москва, 119620, Россия

Pavel A. Romanov - Head of the Radiology Department

38 Aviatorov St., Moscow, 119620, Russia

npc_romanov@mail.ruhttps://orcid.org/0000-0002-0412-4938ШолоховаН. А.SholokhovaN. A.

Шолохова Наталия Александровна - Д-р мед. наук, заведующая отделением лучевой диагностики; профессор кафедры лучевой диагностики

ул. Баррикадная, д. 2/1, стр. 1, г. Москва, 125993, Россия

ул. Матросская Тишина, д. 12А, 107014, г. Москва, Россия 

Nataliya A. Sholokhova - Dr. Sci. (Med.), Head of the Department of Radiology; Professor, Department of Radiology

Barrikadnaya str., 2/1, building 1, Moscow, 125993, Russia

Matrosskaya Tishina St., 12A, 107014, Moscow, Russia 

sholohova@bk.ruhttps://orcid.org/0000-0002-4653-9867КрапивкинА. И.KrapivkinA. I.

Крапивкин Алексей Игорьевич - Д-р мед. наук, директор; профессор кафедры госпитальной педиатрии им. академика В.А. Таболина Института материнства и детства

ул. Авиаторов, д. 38, г. Москва, 119620, Россия

ул. Островитянова, д. 1, г. Москва, 117513, Россия

Aleksey I. Krapivkin - Dr. Sci. (Med.), Director; Professor, Department of Hospital Pediatrics named after Academician V.A. Tabolin

38 Aviatorov St., Moscow, 119620, Russia 

Trubetskaya st., 8/2, Moscow, 119991, Russia

 

KrapivkinAI@zdrav.mos.ruhttps://orcid.org/0009-0005-5229-1131КисловаН. И.KislovaN. I.

Кислова Наталия Игоревна - Младший научный сотрудник; магистр кафедры общественного здоровья и здравоохранения имени Н.А. Семашко

ул. Авиаторов, д. 38, г. Москва, 119620, Россия

ул. Трубецкая, д. 8/2, г. Москва, 119991, Россия

Nataliya I. Kislova - Junior Researcher, State Budgetary Healthcare Institution "Scientific and Practical Center for Specialized Medical Care for Children, Moscow Health  Department," Master's Degree, Department of Public Health and Healthcare named after N.A. Semashko, I.M. Sechenov First Moscow State Medical University

38 Aviatorov St., Moscow, 119620, Russia

Trubetskaya st., 8/2, Moscow, 119991, Russia

KislovaNI@zdrav.mos.ruНаучно-практический центр специализированной медицинской помощи детям имени В.Ф. Войно-ЯсенецкогоРоссияV.F. Voyno-Yasenetsky Scientific and Practical Center for Specialized Medical Care for ChildrenRussian FederationРоссийская медицинская академия непрерывного профессионального образования; Детская городская клиническая больница святого ВладимираРоссияChildren's City Clinical Hospital of St. Vladimir; Russian Medical Academy of Continuous Professional EducationRussian FederationНаучно-практический центр специализированной медицинской помощи детям имени В.Ф. Войно-Ясенецкого; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияV.F. Voyno-Yasenetsky Scientific and Practical Center for Specialized Medical Care for Children; Institute of Maternal and Child Health, N.I. Pirogov Russian National Research Medical UniversityRussian FederationНаучно-практический центр специализированной медицинской помощи детям имени В.Ф. Войно-Ясенецкого; Первый московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияV.F. Voyno-Yasenetsky Scientific and Practical Center for Specialized Medical Care for Children; Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202605092026163219229Copyright © Соколов П.Л., Романов П.А., Шолохова Н.А., Крапивкин А.И., Кислова Н.И., 20262026Соколов П.Л., Романов П.А., Шолохова Н.А., Крапивкин А.И., Кислова Н.И.Sokolov P.L., Romanov P.A., Sholokhova N.A., Krapivkin A.I., Kislova N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/1366

Актуальность. Брюшина является активной серозной оболочкой, участвующей в обеспечении барьерной, транспортной, иммунной и репаративной функций. При воспалении ее морфофункциональные свойства существенно изменяются, что определяет течение перитонита и развитие осложнений.Цель. Обобщить современные данные об анатомии, физиологии брюшины и особенностях ее реакции на воспаление.Материал и методы. Проведен анализ отечественных и зарубежных литературных источников, посвященных гистологии, микроциркуляции, лимфодренажу, мезотелиальной функции и патофизиологии воспаления брюшины.Результаты. Показано, что брюшина представляет собой высокоспециализированный орган с выраженной структурной и функциональной неоднородностью. Мезотелиальные клетки, гликокаликс, субмезотелиальная строма, сосудистая и лимфатическая сети обеспечивают ее барьерные и фибринолитические свойства. При воспалении активируются экссудация, миграция лейкоцитов, экспрессия молекул адгезии и цитокинов, нарушается баланс между фибриногенезом и фибринолизом, что способствует формированию фибрина, спаек и фиброза.Заключение. Брюшина должна рассматриваться как динамичный иммунно-метаболический орган. Изучение ее реакции на воспаление имеет важное значение для понимания патогенеза перитонита и совершенствования его лечения.

Background. The peritoneum is an active serous membrane involved in barrier, transport, immune, and reparative functions. Inflammation significantly alters its morphofunctional properties, thereby influencing the course of peritonitis and the development of complications.Objective. To summarize current knowledge on the anatomy and physiology of the peritoneum and its response to inflammation.Materials and methods. A review of Russian and international literature was performed, focusing on peritoneal histology, microcirculation, lymphatic drainage, mesothelial function, and the pathophysiology of peritoneal inflammation.Results. The peritoneum was shown to be a highly specialized organ with marked structural and functional heterogeneity. Mesothelial cells, the glycocalyx, submesothelial stroma, vascular and lymphatic networks provide barrier and fibrinolytic properties. During inflammation, exudation, leukocyte migration, expression of adhesion molecules and cytokines are activated, while the balance between fibrin formation and fibrinolysis is disrupted, promoting fibrin deposition, adhesions, and fibrosis.Conclusion. The peritoneum should be regarded as a dynamic immunometabolic organ. Studying its response to inflammation is essential for understanding the pathogenesis of peritonitis and improving its treatment.

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The authors declare that there are no conflicts of interest present.