vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2026.2.CLIN.5vmireaviz-1561Research ArticleКлиническая медицинаClinical medicineЗначение коринебактерий в развитии гнойно-воспалительных инфекцийThe Role of Corynebacteria in the Development of Purulent-Inflammatory Infectionshttps://orcid.org/0000-0003-3402-7845ЛазареваЕ. Б.LazarevaE. B.

Лазарева Елена Борисовна - Д-р мед. наук, старший научный сотрудник лаборатории клинической микробиологии 

Большая Сухаревская пл., д. 3, г. Москва, 129090, Россия

Elena B. Lazareva - Dr. Sci. (Med.), Senior Researcher, Clinical Microbiology Laboratory

Bolshaya Sukharevskaya Square, 3, Moscow, 129090, Russia

ellaz@yandex.ruhttps://orcid.org/0000-0002-7088-8645ВладимироваЕ. С.VladimirovaE. S.

Владимирова Елизавета Семеновна - Д-р мед. наук, научный консультант отделения неотложной хирургии,  эндоскопии и интенсивной терапии

Большая Сухаревская пл., д. 3, г. Москва, 129090, Россия

Elizaveta S. Vladimirova - Dr. Sci. (Med.), Scientific consultant of the Department of Emergency Surgery 

Bolshaya Sukharevskaya Square, 3, Moscow, 129090, Russia

VladimirovaES@sklif.mos.ruhttps://orcid.org/0000-0003-1423-5946ЕрмоловаИ. В.YermolovaI. V.

Ермолова Ирина Владимировна - Канд. мед. наук, старший преподаватель учебного отдела

Большая Сухаревская пл., д. 3, г. Москва, 129090, Россия 

Irina V. Ermolova - Cand. Sci. (Med.), Senior Lecturer, Educational Department

Bolshaya Sukharevskaya Square, 3, Moscow, 129090, Russia

irinaermolowa@yandex.ruНаучно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute for Emergency MedicineRussian Federation2026150720261627985Copyright © Лазарева Е.Б., Владимирова Е.С., Ермолова И.В., 20262026Лазарева Е.Б., Владимирова Е.С., Ермолова И.В.Lazareva E.B., Vladimirova E.S., Yermolova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/1561

Цель: систематизировать и обобщить современные данные о роли недифтерийных коринебактерий (Corynebacterium spp.) в развитии гнойновоспалительных инфекций различной локализации, а также рассмотреть актуальные методы их лабораторной диагностики.Материалы и методы. Проведён анализ отечественных и зарубежных публикаций, посвящённых таксономии, биологическим свойствам, патогенетическому потенциалу и антибиотикорезистентности микроорганизмов рода Corynebacterium. Рассмотрены современные методы видовой идентификации – бактериологический, биохимический (API Coryne), молекулярно-генетический (секвенирование гена 16S рРНК) и массспектрометрический (MALDI-ToF-MS).Результаты. Установлено, что более 53 видов коринебактерий имеют клиническое значение. Наиболее часто из инфекционных очагов выделяются C. striatum, C. jeikeium, C. amycolatum, C. simulans, C. aurimucosum и ряд других видов. Они вызывают поражения кожи (эритразма, ямчатый кератолиз), инфицируют ожоговые раны, служат причиной пневмоний, эндокардитов, инфекций мочевыводящих путей, остеомиелита и сепсиса с летальностью до 30%. Ряд видов – C. tuberculostearicum, C. kroppenstedii, C. simulans – ассоциируется с хроническими воспалительными и онкологическими поражениями кожи. Многие клинически значимые виды обладают множественной лекарственной устойчивостью; антибиотиками выбора остаются ванкомицин и линезолид.Заключение. Недифтерийные коринебактерии являются значимыми условно-патогенными микроорганизмами, способными вызывать тяжёлые инфекции у иммунокомпрометированных пациентов. Своевременная видовая идентификация с применением современных методов (MALDI-ToF-MS, секвенирование 16S рРНК) и определение чувствительности к антибиотикам необходимы для повышения эффективности лечения.

Objective. To systematize and summarize current data on the role of nondiphtherial corynebacteria (Corynebacterium spp.) in the development of purulent-inflammatory infections of various anatomic sites and to review current methods of their laboratory diagnosis.Materials and Methods. Analysis of Russian and international publications devoted to taxonomy, biological properties, pathogenetic potential, and antibiotic resistance of microorganisms of the genus Corynebacterium was performed. Current methods of species identification are reviewed: bacteriological, biochemical (API Coryne), molecular genetic (16S rRNA gene sequencing), and mass spectrometric (MALDI-ToF-MS).Results. More than 53 species of corynebacteria have clinical significance. The most frequently isolated from infectious foci are C. striatum, C. jeikeium, C. amycolatum, C. simulans, C. aurimucosum, and several other species. They cause skin lesions (erythrasma, pitted keratolysis), infect burn wounds, cause pneumonia, endocarditis, urinary tract infections, osteomyelitis, and sepsis with mortality rates up to 30%. Several species–C. tuberculostearicum, C. kroppenstedii, C. simulans–are associated with chronic inflammatory and oncologic skin lesions. Many clinically significant species possess multidrug resistance; vancomycin and linezolid remain the antibiotics of choice.Conclusion. Nondiphtherial corynebacteria are significant opportunistic microorganisms capable of causing severe infections in immunocompromised patients. Timely species identification using modern methods (MALDI-ToF-MS, 16S rRNA sequencing) and determination of antibiotic susceptibility are necessary to improve treatment effectiveness.

коринебактериинедифтерийные коринебактериигнойно-воспалительные инфекциицитопатическое действиеожоговые раныантибиотикорезистентностьдиагностикаcorynebacterianon-diphtheria Corynebacteriumpurulent inflammatory infectionscytopathic effectburn woundsantibiotic resistancediagnosticsReferencesChandran R, Puthukkichal DR, Suman E, Mangalore SK. Diphtheroids-Important Nosocomial Pathogens. J Clin Diagn Res. 2016;10(12):DC28-DC31. https://doi.org/10.7860//JCDR//2016/19098.9043 PMID: 28208859Chandran R, Puthukkichal DR, Suman E, Mangalore SK. Diphtheroids-Important Nosocomial Pathogens. J Clin Diagn Res. 2016;10(12):DC28-DC31. https://doi.org/10.7860//JCDR//2016/19098.9043 PMID: 28208859Мангутов Э.О., Харсеева Г.Г., Алутина Э.Л. Corynebacterium spp. – проблемные патогенны респираторного тракта человека (обзор литературы). Клиническая лабораторная диагностика. 2021;66(8):502-508.Mangutov EO, Kharseeva GG, Alutina EL. Corynebacterium spp.–problematic pathogens of the human respiratory tract (literature review). Clin Lab Diagn. 2021;66(8):502-508. (In Russ.)Харсеева Г.Г., Тюкавкина С.Ю., Миронов А.Ю. Дифтерия: характеристика возбудителя и лабораторная диагностика (лекция). Клиническая лабораторная диагностика. 2020;65(11):699-706. https://doi.org/10.1882/0869-2084-2020-65-11-699-706Kharseeva GG, Tyukavkina SY, Mironov AY. Diphtheria: characteristics of the causative agent and laboratory diagnosis (lecture). Clin Lab Diagn. 2020;65(11):699-706. https://doi.org/10.1882/0869-2084-2020-65-11-699-706. (In Russ.)Lehmann KB, Neuman RO. Atlas and principles of bacteriology and text book of special bacteriological diagnosis. Philadelphia: WB Saunders Co; 1901.Lehmann KB, Neuman RO. Atlas and principles of bacteriology and text book of special bacteriological diagnosis. Philadelphia: WB Saunders Co; 1901.Лабинская А.С., Костюкова Н.Н., ред. Руководство по медицинской микробиологии. Оппортунистические инфекции: возбудители и этиологическая диагностика. Москва: БИНОМ; 2013; Кн.3, Т.1.Labinskaya AS, Kostyukova NN, eds. Handbook of Medical Microbiology. Opportunistic Infections: Causative Agents and Etiological Diagnosis. Vol 3, Pt 1. BINOM; 2013. (In Russ.)Bernard К. The genus corynebacterium and other medically relevant coryneform-like bacteria. J Clin Microbiol. 2012;50(10): 3152-3158. https://doi.org/10.1128/JCM.00796-12Bernard К. The genus corynebacterium and other medically relevant coryneform-like bacteria. J Clin Microbiol. 2012;50(10): 3152-3158. https://doi.org/10.1128/JCM.00796-12Ардатская М.Д., Минушкин О.Н. Современные принципы диагностики и фармакологической коррекции. Consilium Medicum. 2006;(2 Приложение. Гастроэнтерология):4-17.Ardatskaya MD, Minushkin ON. Modern principles of diagnosis and pharmacological correction. Consilium Medicum. 2006;(2 suppl, Gastroenterology):4-17. (In Russ.).Wagner J, Ignatius R, Voss S, Höpfner V, Ehlers S, Funke G, et al. Infection of the skin caused by Corynebacterium ulcerans and mimicking classical cutaneous diphtheria. Clin Infect Dis. 2001;33(9):1598-1600. https://doi.org/10.1086/322969 PMID: 11568853Wagner J, Ignatius R, Voss S, Höpfner V, Ehlers S, Funke G, et al. Infection of the skin caused by Corynebacterium ulcerans and mimicking classical cutaneous diphtheria. Clin Infect Dis. 2001;33(9):1598-1600. https://doi.org/10.1086/322969 PMID: 11568853Cantarelli VV, Brodt TC, Secchi C, Inamine E, Pereira FS. Cutaneous infection caused by Corynebacterium pseudodiphtheriticum: a microbiological report. Rev Inst Med Trop Sao Paulo. 2008;50(1):51-52. https://doi.org/10.1590/s0036-46652008000100011Cantarelli VV, Brodt TC, Secchi C, Inamine E, Pereira FS. Cutaneous infection caused by Corynebacterium pseudodiphtheriticum: a microbiological report. Rev Inst Med Trop Sao Paulo. 2008;50(1):51-52. https://doi.org/10.1590/s0036-46652008000100011Forouzan P, Cohen PR. Erythrasma Revisited: Diagnosis, Differential Diagnoses, and Comprehensive Review of Treatment. Cureus. 2020;12(9):e10733. https://doi.org/10.7759/cureus.10733Forouzan P, Cohen PR. Erythrasma Revisited: Diagnosis, Differential Diagnoses, and Comprehensive Review of Treatment. Cureus. 2020;12(9):e10733. https://doi.org/10.7759/cureus.10733Яковлев А.Б. Кератолиз мелкоточечный – бактериальный имитатор микоза кожи стоп (клинические случаи и обзор литературы). Медицинский алфавит. 2022:27:81-88. https://doi.org/10.33667/2078-5631-2022-27-81-84Yakovlev AB. Pitted keratolysis–bacterial mimicker of mycosis of the feet (case reports and literature review). Med Alfavit. 2022;27:81-88. https://doi.org/10.33667/2078-5631-2022-27-81-84. (In Russ.)Pinto M, Hundi GK, Bhat RM, Bala NK, Dandekeri S, Martis J, et al. Clinical and epidemiological features of coryneform skin infections at a tertiary hospital. Indian Dermatol Online J. 2016;7(3):168-173. https://doi.org/10.4103/2229-5178.182351Pinto M, Hundi GK, Bhat RM, Bala NK, Dandekeri S, Martis J, et al. Clinical and epidemiological features of coryneform skin infections at a tertiary hospital. Indian Dermatol Online J. 2016;7(3):168-173. https://doi.org/10.4103/2229-5178.182351Olejniczak-Staruch I, Ciążyńska M, Sobolewska-Sztychny D, Narbutt J, Skibińska M, Lesiak A. Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis. Int J Mol Sci. 2021;22(8):3998. https://doi.org/10.3390/ijms22083998Olejniczak-Staruch I, Ciążyńska M, Sobolewska-Sztychny D, Narbutt J, Skibińska M, Lesiak A. Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis. Int J Mol Sci. 2021;22(8):3998. https://doi.org/10.3390/ijms22083998Hinic V, Lang C, Weisser M, Straub C, Frei R, Goldenberger D. Corynebacterium tuberculostearicum: a potentially misidentified and multiresistant Corynebacterium species isolated from clinical specimens. J Clin Microbiol. 2012;50(8):2561-2567. https://doi.org/10.1128/JCM.00386-12Hinic V, Lang C, Weisser M, Straub C, Frei R, Goldenberger D. Corynebacterium tuberculostearicum: a potentially misidentified and multiresistant Corynebacterium species isolated from clinical specimens. J Clin Microbiol. 2012;50(8):2561-2567. https://doi.org/10.1128/JCM.00386-12Gower CM, Scobie A, Fry NK, Litt DJ, Cameron JC, Chand MA, et al. The changing epidemiology of diphtheria in the United Kingdom, 2009 to 2017. Euro Surveill. 2020;25(11):1900462. https://doi.org/10.2807/1560-7917.ES.2020.25.11.1900462Gower CM, Scobie A, Fry NK, Litt DJ, Cameron JC, Chand MA, et al. The changing epidemiology of diphtheria in the United Kingdom, 2009 to 2017. Euro Surveill. 2020;25(11):1900462. https://doi.org/10.2807/1560-7917.ES.2020.25.11.1900462Sears A, McLean M, Hingston D, Eddie B, Short P, Jones M. Cases of cutaneous diphtheria in New Zealand: implications for surveillance and management. N Z Med J. 2012;125(1350):64-71. PMID: 22382258Sears A, McLean M, Hingston D, Eddie B, Short P, Jones M. Cases of cutaneous diphtheria in New Zealand: implications for surveillance and management. N Z Med J. 2012;125(1350):64-71. PMID: 22382258Богданов С.Б., Зиновьев, Е.В. Османов К.Ф., Каракулев А.В., Поляков А.В., Попов А.А., и др. Совершенствование физических факторов в местном лечении ожоговых ран. Инновационная медицина Кубани. 2019;1(13):44-52.Bogdanov SB, Zinovyev EV, Osmanov KF, et al. Improvement of physical factors in local treatment of burn wounds. Innov Med Kuban. 2019;1(13):44-52. (In Russ.)Ожоги термические и химические. Ожоги солнечные. Ожоги дыхательных путей. Клинические рекомендации Утверждены Минздравом РФ. Москва; 2024. (цитируется 10 марта 2026). Доступно: https://cr.minzdrav.gov.ru/view-cr/687_3?ysclid=m8fxogtalw565761671Thermal and Chemical Burns. Solar Burns. Burns of the Respiratory Tract. Clinical Recommendations. Approved by the Ministry of Health of the Russian Federation. Moscow; 2024. https://cr.minzdrav.gov.ru/view-cr/687_3. (In Russ.)Altonsy MO, Kurwa HA, Lauzon GJ, Amrein M, Gerber AN, Almishri W, et al. Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-κB inflammatory signaling pathway in huan skin cells. Immun Inflamm Dis. 2020;8(1):62–79. https://doi.org/10.1002/iid3.284Altonsy MO, Kurwa HA, Lauzon GJ, Amrein M, Gerber AN, Almishri W, et al. Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-κB inflammatory signaling pathway in huan skin cells. Immun Inflamm Dis. 2020;8(1):62–79. https://doi.org/10.1002/iid3.284Андреева С.В., Бахарева Л.И., Нохрин Д.Ю. Видовой состав микрофлоры ожоговых ран пациентов Челябинской области ожогового центра. Вестник Челябинского государственного университета. 2013;7(298):58-59.Andreeva SV, Bakhareva LI, Nokhrin DY. Species composition of microflora of burn wounds in patients of Chelyabinsk region burn center. Vestn Chelyab State Univ. 2013;7(298):58-59. (In Russ.)Gupta S, Poret AJ, Hashemi D, Eseonu A, Yu SH, D'Gama J, et al. Cutaneous Surgical Wounds Have Distinct Microbiomes from Intact Skin. Microbiol Spectr. 2023;11(1):e0330022. https://doi.org/10.1128/spectrum.03300-22Gupta S, Poret AJ, Hashemi D, Eseonu A, Yu SH, D'Gama J, et al. Cutaneous Surgical Wounds Have Distinct Microbiomes from Intact Skin. Microbiol Spectr. 2023;11(1):e0330022. https://doi.org/10.1128/spectrum.03300-22Мангутов Э.О., Харсеева Г.Г., Герасимов В.Н., Алиева А.А., Воронина Н.А., Алутина Э.Л., и др. Corynebacterium spp.: недооцененные патогены с высоким потенциалом вирулентности. Эпидемиология и Вакцинопрофилактика. 2022;21(4):80-88. https://doi.o27rg/10.31631/2073-3046-2022-21-4-80-88Mangutov EO, Kharseeva GG, Gerasimov VN, et al. Corynebacterium spp.: underestimated pathogens with high virulence potential. Epidemiol Vakcinoprofilaktika. 2022;21(4):80-88. https://doi.org/10.31631/2073-3046-2022-21-4-80-88. (In Russ.)Díez-Aguilar M, Ruiz-Garbajosa P, Fernández-Olmos A, Guisado P, Del Campo R, Quereda C, et al. Non-diphtheriae Corynebacterium species: an emerging respiratory pathogen. Eur J Clin Microbiol Infect Dis. 2013;32(6):769-772. https://doi.org/10.1007/s10096-012-1805-5Díez-Aguilar M, Ruiz-Garbajosa P, Fernández-Olmos A, Guisado P, Del Campo R, Quereda C, et al. Non-diphtheriae Corynebacterium species: an emerging respiratory pathogen. Eur J Clin Microbiol Infect Dis. 2013;32(6):769-772. https://doi.org/10.1007/s10096-012-1805-5Nishiyama A, Ishida T, Ito A, Arita M. Bronchopneumonia caused by Corynebacterium pseudodiphtheriticum. Intern Med. 2013;52:1847. https://doi.org/10.2169/internalmedicine.52.9560Nishiyama A, Ishida T, Ito A, Arita M. Bronchopneumonia caused by Corynebacterium pseudodiphtheriticum. Intern Med. 2013;52:1847. https://doi.org/10.2169/internalmedicine.52.9560Gupta R, Popli T, Ranchal P, Khosla J, Aronow WS, Frishman WH, et al. Corynebacterium jekeium endocarditis: a review of the literature. Cardiol Rev. 2021; 29(5): 259-262. https://doi.org/10.1097/CRD.0000000000000355Gupta R, Popli T, Ranchal P, Khosla J, Aronow WS, Frishman WH, et al. Corynebacterium jekeium endocarditis: a review of the literature. Cardiol Rev. 2021; 29(5): 259-262. https://doi.org/10.1097/CRD.0000000000000355Clariot S, Constant O, Lepeule R, Fihman V, Razazi K., Cook F, et al. Clinical relevance and impact of Corynebacterium isolation in lower respiratory tract of critically ill patients requiring mechanical ventilation. Infection. 2020;48(3):413-420. https://doi.org/10.1007/s15010-020-01411-w PMID: 32185636Clariot S, Constant O, Lepeule R, Fihman V, Razazi K., Cook F, et al. Clinical relevance and impact of Corynebacterium isolation in lower respiratory tract of critically ill patients requiring mechanical ventilation. Infection. 2020;48(3):413-420. https://doi.org/10.1007/s15010-020-01411-w PMID: 32185636Sagerfors S, Poehlein A, Afshar M, Lindblad BE, Brüggemann H, Söderquist B. Clinical and genomic features of Corynebacterium macginleyi-associated infectious keratitis. Sci Rep. 2021;11(1):6015. https://doi.org/10.1038/s41598-021-85336-wSagerfors S, Poehlein A, Afshar M, Lindblad BE, Brüggemann H, Söderquist B. Clinical and genomic features of Corynebacterium macginleyi-associated infectious keratitis. Sci Rep. 2021;11(1):6015. https://doi.org/10.1038/s41598-021-85336-wTrivedi GR, Merchant SS. Corynebacterium striatum: A True Pathogen in Chronic Contiguous Osteomyelitis. Can J Infect Dis Med Microbiol. 2024;2024:5020721. https://doi.org/10.1155/2024/5020721Trivedi GR, Merchant SS. Corynebacterium striatum: A True Pathogen in Chronic Contiguous Osteomyelitis. Can J Infect Dis Med Microbiol. 2024;2024:5020721. https://doi.org/10.1155/2024/5020721Cacopardo B, Stefani S, Cardi F, Cardi C, Pinzone MR, Nunnari G. Surgical Site Infection by Corynebacterium macginleyi in a Patient with Neurofibromatosis Type 1. Case Rep Infect Dis. 2013;2013:970678. https://doi.org/10.1155/2013/970678. PMID: 23819079Cacopardo B, Stefani S, Cardi F, Cardi C, Pinzone MR, Nunnari G. Surgical Site Infection by Corynebacterium macginleyi in a Patient with Neurofibromatosis Type 1. Case Rep Infect Dis. 2013;2013:970678. https://doi.org/10.1155/2013/970678. PMID: 23819079Yamamuro R, Hosokawa N, Otsuka Y, Osawa R. Clinical Characteristics of Corynebacterium Bacteremia Caused byDifferent Species, Jahan, 2014-2020. Emerg Infect Dis. 2021;27(12):2981-2987. https://doi.org/10.3201/eid2712.219473 PMID: 34812137Yamamuro R, Hosokawa N, Otsuka Y, Osawa R. Clinical Characteristics of Corynebacterium Bacteremia Caused byDifferent Species, Jahan, 2014-2020. Emerg Infect Dis. 2021;27(12):2981-2987. https://doi.org/10.3201/eid2712.219473 PMID: 34812137McElvania TeKippe E, Thomas BS, Ewald GA, Lawrence SJ, Burnham CA. Rapid emergence of daptomycin resistance in clinical isolates of Corynebacterium striatum… a cautionary tale. Eur J Clin Microbiol Infect Dis. 2014;33(12):2199-2205. https://doi.org/10.1007/s10096-014-2188-6McElvania TeKippe E, Thomas BS, Ewald GA, Lawrence SJ, Burnham CA. Rapid emergence of daptomycin resistance in clinical isolates of Corynebacterium striatum… a cautionary tale. Eur J Clin Microbiol Infect Dis. 2014;33(12):2199-2205. https://doi.org/10.1007/s10096-014-2188-6McMullen AR, Anderson N, Wallace MA, Shupe A, Burnham CA. When Good Bugs Go Bad: Epidemiology and Antimicrobial Resistance Profiles of Corynebacterium striatum, an Emerging Multidrug-Resistant, Opportunistic Pathogen. Antimicrob Agents Chemother. 2017; 61(11): e01111-1117. https://doi.org/10.1128/AAC.01111-17McMullen AR, Anderson N, Wallace MA, Shupe A, Burnham CA. When Good Bugs Go Bad: Epidemiology and Antimicrobial Resistance Profiles of Corynebacterium striatum, an Emerging Multidrug-Resistant, Opportunistic Pathogen. Antimicrob Agents Chemother. 2017; 61(11): e01111-1117. https://doi.org/10.1128/AAC.01111-17Shao H, Luo R, Wang X, Pan X, Chen G. Management of a patient with small-area burns, severe sepsis and superficial vein thrombosis. J Wound Care. 2015;24(2):73-74, 77-78. https://doi.org/10.12968/jowc.2015.24.2.73Shao H, Luo R, Wang X, Pan X, Chen G. Management of a patient with small-area burns, severe sepsis and superficial vein thrombosis. J Wound Care. 2015;24(2):73-74, 77-78. https://doi.org/10.12968/jowc.2015.24.2.73Wattiau P, Janssens M, Wauters G. Corynebacterium simulans sp. nov., a non-lipophilic, fermentative Corynebacterium. Int J Syst Evol Microbiol. 2000;50(Pt 1):347-353. https://doi.org/10.1099/00207713-50-1-347Wattiau P, Janssens M, Wauters G. Corynebacterium simulans sp. nov., a non-lipophilic, fermentative Corynebacterium. Int J Syst Evol Microbiol. 2000;50(Pt 1):347-353. https://doi.org/10.1099/00207713-50-1-347Ogasawara M, Matsuhisa T, Kondo T, Sato J. Clinical characteristics of Corynebacterium simulans. Nagoya J Med Sci. 2021;83(2):269-276. https://doi.org/10.18999/nagjms.83.2.269Ogasawara M, Matsuhisa T, Kondo T, Sato J. Clinical characteristics of Corynebacterium simulans. Nagoya J Med Sci. 2021;83(2):269-276. https://doi.org/10.18999/nagjms.83.2.269Hon SA, Lee LT, Low QJ. An Unusual Case of Corynebacterium simulans causes Infective Endocarditis with Embolic Events. Borneo J Med Sci. 2023;17(2):36-41. https://doi.org/10.51200/bjms.v17i2.3804Hon SA, Lee LT, Low QJ. An Unusual Case of Corynebacterium simulans causes Infective Endocarditis with Embolic Events. Borneo J Med Sci. 2023;17(2):36-41. https://doi.org/10.51200/bjms.v17i2.3804Nagassar RP, Nicholson AM, Williams W, Bridgelal-Nagassar RJ. Diphtheroids as a cause of endocarditis in a haemodialysis patient. BMJ Case Rep. 2012;2012:bcr1020114894. https://doi.org/10.1136/bcr.10.2011.4894Nagassar RP, Nicholson AM, Williams W, Bridgelal-Nagassar RJ. Diphtheroids as a cause of endocarditis in a haemodialysis patient. BMJ Case Rep. 2012;2012:bcr1020114894. https://doi.org/10.1136/bcr.10.2011.4894Анохин В.А., Халиуллина С.В., Назарова О.А., Хаертынов Х.С. Случай раннего неонатального сепсиса, обусловленного Corynebacterium amycolatum. Практическая медицина. 2012;7(62):178-180.Anokhin VA, Khaliullina SV, Nazarova OA, Khaertynov KH. A case of early neonatal sepsis caused by Corynebacterium amycolatum. PraktBerner R, Pelz K, Wilhelm C, Funke A, Leititis JU, Brandis M. Fatal sepsis caused by Corynebacterium amycolatum in a premature infant. J Clin Microbiol. 1997;35(4):1011-1012. https://doi.org/10.1128/jcm.35.4.1011-1012.1997Med. 2012;7(62):178-180. (In Russ.)Trost E, Götker S, Schneider J, Schneiker-Bekel S, Szczepanowski R, Tilker A, et al. Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion. BMC Genomics. 2010;11:91. https://doi.org/10.1186/1471-2164-11-91Berner R, Pelz K, Wilhelm C, Funke A, Leititis JU, Brandis M. Fatal sepsis caused by Corynebacterium amycolatum in a premature infant. J Clin Microbiol. 1997;35(4):1011-1012. https://doi.org/10.1128/jcm.35.4.1011-1012.1997Lefèvre CR, Pelletier R, Le Monnier A, Corvec S, Bille E, Potron A, et al. Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum. J Med Microbiol. 2021;70(3). https://doi.org/10.1099/jmm.0.001334Trost E, Götker S, Schneider J, Schneiker-Bekel S, Szczepanowski R, Tilker A, et al. Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion. BMC Genomics. 2010;11:91. https://doi.org/10.1186/1471-2164-11-91Funke G, Ramos CP, Collins MD. Corynebacterium coyleae sp. nov., isolated from human clinical specimens. Int J Syst Bacteriol. 1997;47(1): 92-96. https://doi.org/10.1099/00207713-47-1-92 PMID: 8995809Lefèvre CR, Pelletier R, Le Monnier A, Corvec S, Bille E, Potron A, et al. Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen Corynebacterium aurimucosum. J Med Microbiol. 2021;70(3). https://doi.org/10.1099/jmm.0.001334Taguchi M, Nishikawa S, Matsuoka H, Narita R, Abe S, Fukuda K, et al. Pancreatic abscess caused by Corynebacterium coyleae mimicking malignant neoplasm. Pancreas. 2006;33(4):425-429. https://doi.org/10.1097/01.mpa.0000236730.08747.69Funke G, Ramos CP, Collins MD. Corynebacterium coyleae sp. nov., isolated from human clinical specimens. Int J Syst Bacteriol. 1997;47(1): 92-96. https://doi.org/10.1099/00207713-47-1-92 PMID: 8995809Sokol-Leszczynska B, Leszczynski P, Lachowicz D, Rostkowska O, Niemczyk M, Piecha T, et al. Corynebacterium coyleae as potential urinary tract pathogen. Eur J Clin Microbiol Infect Dis. 2019;38(7):1339–1342. https://doi.org/10.1007/s10096-019-03565-4Taguchi M, Nishikawa S, Matsuoka H, Narita R, Abe S, Fukuda K, et al. Pancreatic abscess caused by Corynebacterium coyleae mimicking malignant neoplasm. Pancreas. 2006;33(4):425-429. https://doi.org/10.1097/01.mpa.0000236730.08747.69Iroh Tam PY, Fisher MA, Miller NS. Corynebacterium falsenii bacteremia occurring in an infant on vancomycin therapy. J Clin Microbiol. 2010;48(9):3440-3442. https://doi.org/10.1128/JCM.00990-10Sokol-Leszczynska B, Leszczynski P, Lachowicz D, Rostkowska O, Niemczyk M, Piecha T, et al. Corynebacterium coyleae as potential urinary tract pathogen. Eur J Clin Microbiol Infect Dis. 2019;38(7):1339–1342. https://doi.org/10.1007/s10096-019-03565-4Fernández-Garayzábal JF, Egido R, Vela AI, Briones V, Collins MD, Mateos A, et al. Isolation of Corynebacterium falsenii and description of Corynebacterium aquilae sp. nov., from eagles. Int J Syst Evol Microbiol. 2003;53(Pt 4):1135-1138. https://doi.org/10.1099/ijs.0.02533-0Iroh Tam PY, Fisher MA, Miller NS. Corynebacterium falsenii bacteremia occurring in an infant on vancomycin therapy. J Clin Microbiol. 2010;48(9):3440-3442. https://doi.org/10.1128/JCM.00990-10Glaub A, Bomholt C, Gravermann K, Brinkrolf K, Albersmeier A, Rückert C, et al. Complete Genome Sequence of Corynebacterium falsenii DSM 44353 To Study the Evolution of Corynebacterium Cluster 3 Species. Genome Announc. 2014;2(2):e00158-14. https://doi.org/10.1128/genomeA.00158-14Fernández-Garayzábal JF, Egido R, Vela AI, Briones V, Collins MD, Mateos A, et al. Isolation of Corynebacterium falsenii and description of Corynebacterium aquilae sp. nov., from eagles. Int J Syst Evol Microbiol. 2003;53(Pt 4):1135-1138. https://doi.org/10.1099/ijs.0.02533-0Riegel P, Ruimy R, De Briel D, Prevost G, Jehl F, Bimet F, et al. Corynebacterium argentoratense sp. nov., from the human throat. Int J Syst Bacteriol. 1995;45(3):533-537. https://doi.org/10.1099/00207713-45-3-533Glaub A, Bomholt C, Gravermann K, Brinkrolf K, Albersmeier A, Rückert C, et al. Complete Genome Sequence of Corynebacterium falsenii DSM 44353 To Study the Evolution of Corynebacterium Cluster 3 Species. Genome Announc. 2014;2(2):e00158-14. https://doi.org/10.1128/genomeA.00158-14Funke G, Frodl R. Comprehensive Study of Corynebacterium freneyi Strains and Extended and Emended Description of Corynebacterium freneyi Renaud, Aubel, Riegel, Meugnier, and Bollet. 2001. J Clin Microbiol. 2008;46(2):638-643. https://doi.org/10.1128/JCM.01491-07Riegel P, Ruimy R, De Briel D, Prevost G, Jehl F, Bimet F, et al. Corynebacterium argentoratense sp. nov., from the human throat. Int J Syst Bacteriol. 1995;45(3):533-537. https://doi.org/10.1099/00207713-45-3-533Auzias A, Bollet C, Ayari R, Drancourt M, Raoult D. Corynebacterium freneyi bacteremia. J Clin Microbiol. 2003;41(6):2777-2778. https://doi.org/10.1128/JCM.41.6.2777-2778.2003Funke G, Frodl R. Comprehensive Study of Corynebacterium freneyi Strains and Extended and Emended Description of Corynebacterium freneyi Renaud, Aubel, Riegel, Meugnier, and Bollet. 2001. J Clin Microbiol. 2008;46(2):638-643. https://doi.org/10.1128/JCM.01491-07Фенотипическая идентификация бактерий рода Соrуnеbacterium: Методические рекомендации. Москва: Федеральный центр гигиены и эпидемиологии Роспотребнадзора; 2011.Auzias A, Bollet C, Ayari R, Drancourt M, Raoult D. Corynebacterium freneyi bacteremia. J Clin Microbiol. 2003;41(6):2777-2778. https://doi.org/10.1128/JCM.41.6.2777-2778.2003Харсеева Г.Г., Воронина Н.А., Миронов А.Ю. Методы идентификации Corynebacterium non diphtheriae. Клиническая лабораторная диагностика. 2016; 61(4): 245-249. https://doi.org/10.18821/0869-2084-2016-4-245-249Phenotypic Identification of Bacteria of the Genus Corynebacterium: Methodological Recommendations. Federal Center of Hygiene and Epidemiology of Rospotrebnadzor; 2011. (In Russ.)Kharseeva GG, Voronina NA, Mironov AY. Methods for identification of Corynebacterium non diphtheriae. Clin Lab Diagn. 2016;61(4):245-249.Kharseeva GG, Voronina NA, Mironov AY. Methods for identification of Corynebacterium non diphtheriae. Clin Lab Diagn. 2016;61(4):245-249.https://doi.org/10.18821/0869-2084-2016-4-245-249. (In Russ.)https://doi.org/10.18821/0869-2084-2016-4-245-249. (In Russ.)

The authors declare that there are no conflicts of interest present.