References

vmireaviz

Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье

Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)

2226-762X2782-1579

РЕАВИЗ

10.20340/vmi-rvz.2026.2.PHYS.3

vmireaviz-1683

Research Article

Физиология

Physiology

Изменение концентраций тиобарбитуровой кислоты реагирующих субстратов в плазме крови и тестикулярных тканей крыс после общего однократного гамма-излучения в дозе 1,0 Гр

Changes in concentrations of thiobarbituric acid reacting substrates in blood plasma and testicular tissues of rats after a total single gamma radiation dose of 1.0 Gy

https://orcid.org/0009-0000-0188-9006

Аль Меселмани

М. А.

Al Meselmani

M. A.

Аль Меселмани Моханад Али - Канд. биол. наук, доцент кафедры биохимии и биоинформатики

Author ID: 1200106

ул. Днепровской флотилии, д. 23, г. Пинск, 225710, Беларусь

Al Meselmani Mohanad Ali - Cand. Sci. (Biol.), Associate Professor of the Department of Biochemistry and Bioinformatics

Dneprovskoy Flotilla St., 23, Pinsk, 225710, Belarus

al-meselmani.m@polessu.by

Полесский государственный университетБеларусьPolessky State UniversityBelarus

2026

15072026

1623241

2026

Аль Меселмани М.А.

Al Meselmani M.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vestnik.reaviz.ru/jour/article/view/1683

Цель исследования: изучение содержания ТБК-реагирующих субстратов в плазме крови и тестикулярных тканях крыс в условиях гамма-облучения.Материал и методы. В плазме крови и тестикулярных тканях крыс самцов линии Wistar концентрация ТБКРС определена по методу (Ohkawa) через 3, 10 и 40 суток после тотального гамма-облучения при дозе 1,0 Гр.Результаты. Установлено, что на 3 сутки после гамма-облучения содержание ТБКРС в плазме крови и тестикулярных тканях соответственно повышались на 91,2% (p<0,05) и 81,6% (p<0,05) по сравнению с контролем. Через 10 суток наблюдения увеличение содержания ТБКРС возросло до 232,1% (p<0,05) в плазме крови и 295,9% (p<0,01) в тестикулярных тканях. К 40 суткам после облучения концентрации ТБКРС были 159,3% (p<0,01) и 208,2% (p<0,05) в плазме крови и тестикулярных тканях соответственно.Заключение. Увеличение содержания ТБКРС в плазме крови и тестикулярных тканях у облучённых крыс спустя 40 суток дополнительно (наглядно) подтверждает продолжительную активацию процессов ПОЛ, считавшихся причиной многочисленных заболеваний репродуктивной системы у мужчин.

Purpose: the aim of the study was to study the content of TBА-reacting substrates in blood plasma and testicular tissues of rats under gamma irradiation conditions.Materials and methods. In the blood plasma and testicular tissues of male Wistar rats, the concentration of TBАRS was determined by the (Ohkawa) method for3,10 and 40 days after total gamma radiation at a dose of 1.0Gy.Results. It was found that on three days after gamma irradiation, the content of TBАRS in blood plasma and testicular tissues increased by 91.2% (p<0.05) and 81.6% (p<0.05), respectively, compared with the control. After ten days of follow-up, the increase in TBАRS content reached 232.1% (p<0.05) in blood plasma and 295.9% (p<0.01) in testicular tissues. By forty days after irradiation, the concentrations of TBАRS were 159.3% (p<0.01) and 208.2% (p<0.05) in blood plasma and testicular tissues, respectively.Conclusion. An increase in the content of TBАRS in blood plasma and testicular tissues in irradiated rats forty days later additionally and clearly confirms the prolonged activation of lipid peroxidation (LPO) processes, which are considered a cause of numerous diseases of the reproductive system in men.

ТБК-реагирующие субстратыперекисное окисление липидовокислительный стресссеменникигамма-лучиплазма кровималоновый диальдегидкрысы линии Вистар

Thiobarbituric Acid Reactive SubstancesLipid PeroxidationOxidative StresTestisGamma RaysPlasmaMalondialdehydeRatsWistar

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The authors declare that there are no conflicts of interest present.