vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2021.4.CLIN.1vmireaviz-253Research ArticleКлиническая медицинаClinical medicineФармакологические аспекты лечения острой гликозидной интоксикацииPharmacological aspects of acute treatment glycoside intoxicationhttps://orcid.org/0000-0002-3274-2290ШперлингМ. И.SperlingM. I.

Шперлинг Максим Игоревич, клинический ординатор, Первая кафедра и клиника (терапии усовершенствования врачей) имени академика Н.С. Молчанова

Санкт-Петербург

St. Petersburg

https://orcid.org/0000-0003-1417-0636КручининЕ. Г.KruchininE. G.

Кручинин Евгений Геннадьевич, кандидат медицинских наук, заместитель начальника отдела

Санкт-Петербург

St. Petersburg

https://orcid.org/0000-0002-7625-2744ГоголевскийА. С.GogolevskyA. S.

Гоголевский Александр Сергеевич, доктор медицинских наук, начальник Центра

Санкт-Петербург

St. Petersburg

Военно-медицинская академия им. С.М. КироваРоссияMilitary Medical Academy named after V.I. CM. KirovRussian FederationГосударственный научно-исследовательский испытательный институт военной медициныРоссияState Research and Testing Institute military medicineRussian Federation20210607202104120134Copyright © Шперлинг М.И., Кручинин Е.Г., Гоголевский А.С., 20212021Шперлинг М.И., Кручинин Е.Г., Гоголевский А.С.Sperling M.I., Kruchinin E.G., Gogolevsky A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/253

Несмотря на активное внедрение хирургических методов лечения сердечной патологии и новых синтетических кардиотонических средств, сердечные гликозиды (СГ) остаются важной составляющей фармакологической терапии заболеваний сердца. Более того, интерес к данной группе препаратов только возрастает с учетом открытия новых фармакологических эффектов, таких как противоопухолевый и противовирусный. Однако, несмотря на многолетний опыт применения, вопрос ведения пациентов с симптомами как острой, так и хронической интоксикации СГ остается одним из ведущих. В обзоре литературы приводится краткий исторический очерк отравлений сердечными гликозидами, описываются особенности фармакокинетики и фармакодинамики данной группы препаратов. Рассмотрена клиническая картина отравлений СГ. Проанализированы современные представления и ограничения антидотной терапии, а также особенности патогенетического и симптоматического лечения пациентов с острой гликозидной интоксикацией.

Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases. Moreover, interest in this group of drugs is only increasing with the discovery of new pharmacological effects, such as antitumor and antiviral. However, despite many years of experience, the issue of managing patients with symptoms of both acute and chronic poisoning with cardiac glycosides remains one of the leading ones. The literature review provides a brief historical outline of cardiac glycoside poisoning and comprehensively describes the pharmacokinetics and pharmacodynamics of this group of drugs. The clinical picture of intoxication is described. We analyzed modern ideas and limitations of using antidote therapy such as digoxin immune Fab-antibody fragments, as well as the features of pathogenetic and symptomatic treatment of patients with acute glycoside poisoning.

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The authors declare that there are no conflicts of interest present.