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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmirvz.2021.5.CLIN.5</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-295</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая медицина</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical medicine</subject></subj-group></article-categories><title-group><article-title>Показатели серотонина в биологических жидкостях как маркер диагностики и эффективности лечения нейроортопедических заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Serotonin level in biological fluids as a marker of neuroorthopedic diseases diagnostics and treatment efficiency</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9855-548X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виндерлих</surname><given-names>М. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Winderlich</surname><given-names>M. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виндерлих Марина Евгеньевна, доцент кафедры педиатрии, Медицинский институт</p><p>Йошкар-Ола </p></bio><bio xml:lang="en"><p>Yoshkar-Ola </p></bio><email xlink:type="simple">vinderlikh@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3911-4545</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щеколова</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchekolova</surname><given-names>N. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щеколова Наталья Борисовна, доктор медицинских наук, профессор, профессор кафедры травматологии, ортопедии и нейрохирургии</p><p>Пермь </p></bio><bio xml:lang="en"><p>Perm </p></bio><email xlink:type="simple">vinderlikh@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Марийский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Maria State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Пермский государственный медицинский университет имени академика Е.А. Вагнера</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm State Medical University named after academician E.A. Wagner</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>23</day><month>08</month><year>2021</year></pub-date><volume>11</volume><issue>5</issue><fpage>105</fpage><lpage>112</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Виндерлих М.Е., Щеколова Н.Б., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Виндерлих М.Е., Щеколова Н.Б.</copyright-holder><copyright-holder xml:lang="en">Winderlich M.E., Shchekolova N.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/295">https://vestnik.reaviz.ru/jour/article/view/295</self-uri><abstract><p>В данной статье рассмотрены вопросы изучения динамики изменения серотонина в биологических жидкостях как маркера при различных нейроортопедических заболеваниях у пациентов разного возраста. Для этого проведен анализ клинической практики. Сделан вывод о том, что изменение уровня серотонина может рассматриваться в качестве индикатора болевых ощущений и контроля проводимой терапии при нейроортопедических патологиях. Обозначена необходимость проведения дальнейшего углубленного изучения имеющейся практики оценки изменения уровня серотонина в биологических жидкостях в ходе консервативного лечения и после оперативного вмешательства в различных случаях нейроортопедических заболеваний у разновозрастных пациентов.</p></abstract><trans-abstract xml:lang="en"><p>This article discusses the issues of studying the dynamics of changes in serotonin in biological fluids as a marker in various neuro-orthopedic diseases in patients of different ages. For this, an analysis of clinical practice has been carried out. It is concluded that changes in serotonin levels can be considered as an indicator of pain sensations and control of ongoing therapy in neuro-orthopedic pathologies. The need for a further indepth study of the existing practice of assessing changes in the level of serotonin in biological fluids during conservative treatment and after surgery in various cases of neuro-orthopedic diseases in patients of different ages is indicated.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нейроортопедические заболевания</kwd><kwd>серотонин</kwd><kwd>диагностика</kwd><kwd>боль</kwd><kwd>успешность проведения терапии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neuro-orthopedic diseases</kwd><kwd>serotonin</kwd><kwd>diagnostics</kwd><kwd>indicator</kwd><kwd>pain</kwd><kwd>therapy success</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Borisova L.I. Spinal canal stenosis: clinical neurology, quality of life and humoral serotonin before and after surgical treatment: dis. ... cand. honey. sciences. Perm, 2012.183 p. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Borisova L.I. Spinal canal stenosis: clinical neurology, quality of life and humoral serotonin before and after surgical treatment: dis. ... cand. honey. sciences. Perm, 2012.183 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gorozhaninova E.V., Loginova N.V. Assessment of humoral serotonin, pain and mental status of patients with spastic torticollis. Materials of the 93rd final scientific-practical conference of students, residents, graduate students, young scientists (up to 35 years old) "Young science – practical health care". PSMU named after academician E.A. Wagner. April 13-17, 2020 Perm: Perm State Medical University. 2020:52-55. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Gorozhaninova E.V., Loginova N.V. Assessment of humoral serotonin, pain and mental status of patients with spastic torticollis. Materials of the 93rd final scientific-practical conference of students, residents, graduate students, young scientists (up to 35 years old) "Young science – practical health care". PSMU named after academician E.A. Wagner. April 13-17, 2020 Perm: Perm State Medical University. 2020:52-55. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gorina A.S., Goetze S., Kolesnichenko L.S. Age-related dynamics of monoaminoergic neurotransmitters in cerebrospinal fluid in autism, attention deficit hyperactivity disorder and their comorbidity. Siberian Medical Journal (Irkutsk). 2013;117(2):34-37. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Gorina A.S., Goetze S., Kolesnichenko L.S. Age-related dynamics of monoaminoergic neurotransmitters in cerebrospinal fluid in autism, attention deficit hyperactivity disorder and their comorbidity. Siberian Medical Journal (Irkutsk). 2013;117(2):34-37. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kazakova M.S. The influence of the therapeutic factors of the Klyuchi resort on pain. psychovegetative status and humoral serotonin in patients with cervical dorsopathy: author. dis. ... cand. honey. sciences. Perm, 2009. 21 p. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Kazakova M.S. The influence of the therapeutic factors of the Klyuchi resort on pain. psychovegetative status and humoral serotonin in patients with cervical dorsopathy: author. dis. ... cand. honey. sciences. Perm, 2009. 21 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Karakulova Yu. V. Serotonin system of peripheral blood of patients with tension headache (clinical and biochemical study): dis. … doc. honey. sciences. Perm, 2006. 239 p. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Karakulova Yu. V. Serotonin system of peripheral blood of patients with tension headache (clinical and biochemical study): dis. … doc. honey. sciences. Perm, 2006. 239 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kushlinsky N.E., Lyubimova N.V. Biochemical markers in the diagnosis of neuroendocrine tumors. Clinical laboratory diagnostics. 2014;7:4-11. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Kushlinsky N.E., Lyubimova N.V. Biochemical markers in the diagnosis of neuroendocrine tumors. Clinical laboratory diagnostics. 2014;7:4-11. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lobzin S.V [and others]. Some indicators of dysfunction of neurotransmitter systems in dystonia and essential tremor. Bulletin of the North-Western State Medical University named after I. I.I. Mechnikov. 2016;6(2): 38-41. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Lobzin S.V [and others]. Some indicators of dysfunction of neurotransmitter systems in dystonia and essential tremor. Bulletin of the North-Western State Medical University named after I. I.I. Mechnikov. 2016;6(2): 38-41. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Loginova N.V. Clinical characteristics of hyperkinesis and peripheral blood serotonin in patients with focal muscular dystonia before and after botulinum therapy: dis. ... cand. honey. sciences. Perm, 2019.153 p. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Loginova N.V. Clinical characteristics of hyperkinesis and peripheral blood serotonin in patients with focal muscular dystonia before and after botulinum therapy: dis. ... cand. honey. sciences. Perm, 2019.153 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lychkova A.E., Puzikov A.M. Prolactin and serotonin. Bulletin of the Russian Academy of Medical Sciences. 2014;69(1–2):38-45. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Lychkova A.E., Puzikov A.M. Prolactin and serotonin. Bulletin of the Russian Academy of Medical Sciences. 2014;69(1–2):38-45. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mikheeva I.G., Ryukert E.N., Brusov O.S. et al. Serotonin content in blood serum of newborns with hypoxicischemic lesions of the central nervous system Pediatrics. 2008;87(1):40-44. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Mikheeva I.G., Ryukert E.N., Brusov O.S. et al. Serotonin content in blood serum of newborns with hypoxicischemic lesions of the central nervous system Pediatrics. 2008;87(1):40-44. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sheibak L. N., Katkova E. V. Serotonin and its derivatives in umbilical cord blood serum of premature newborns. Russian Bulletin of Perinatology and Pediatrics. 2010;4:27-30. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Sheibak L. N., Katkova E. V. Serotonin and its derivatives in umbilical cord blood serum of premature newborns. Russian Bulletin of Perinatology and Pediatrics. 2010;4:27-30. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Striebel H.V. Chronic Pain Therapy: A Practical Guide. Moscow: GEOTAR-Media, 2015. 304 p. (In Russ).</mixed-citation><mixed-citation xml:lang="en">Striebel H.V. Chronic Pain Therapy: A Practical Guide. Moscow: GEOTAR-Media, 2015. 304 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ardill J.E. Circulating markers for endocrine tumours of the gastroenteropancreatic tract. Annals of Clinical Biochemistry. 2008;45(6):539-559.</mixed-citation><mixed-citation xml:lang="en">Ardill J.E. Circulating markers for endocrine tumours of the gastroenteropancreatic tract. Annals of Clinical Biochemistry. 2008;45(6):539-559.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Benekareddy, M., Vadodaria, K. C., Nair, A. R., and Vaidya, V. A. Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Biol. Psychiatry. 2011;70:1024-1032. https://doi.org/10.1016/j.biopsych.2011.08.005</mixed-citation><mixed-citation xml:lang="en">Benekareddy, M., Vadodaria, K. C., Nair, A. R., and Vaidya, V. A. Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Biol. Psychiatry. 2011;70:1024-1032. https://doi.org/10.1016/j.biopsych.2011.08.005</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Booij L., Tremblay R.E., Szyf M. and Benkelfat C. Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology. J. Psychiatry Neurosci. 2015;40:5–18. https://doi.org/10.1503/jpn.140099</mixed-citation><mixed-citation xml:lang="en">Booij L., Tremblay R.E., Szyf M. and Benkelfat C. Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology. J. Psychiatry Neurosci. 2015;40:5–18. https://doi.org/10.1503/jpn.140099</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Boukhris T., Sheehy O., Mottron L. and Berard A. Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatr. 2015;70:117-124. https://doi.org/10.1001/jamapediatrics.2015.3356</mixed-citation><mixed-citation xml:lang="en">Boukhris T., Sheehy O., Mottron L. and Berard A. Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatr. 2015;70:117-124. https://doi.org/10.1001/jamapediatrics.2015.3356</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Brummelte S., Mc Glanaghy E., Bonnin A., Oberlander T.F. Developmental changes in serotonin signaling: implications for early brain function, behavior and adaptation. Neuroscience. 2017;342:212-231.PMID: 26905950 https://doi.org/10.1016/j.neuroscience.2016.02.037</mixed-citation><mixed-citation xml:lang="en">Brummelte S., Mc Glanaghy E., Bonnin A., Oberlander T.F. Developmental changes in serotonin signaling: implications for early brain function, behavior and adaptation. Neuroscience. 2017;342:212-231.PMID: 26905950 https://doi.org/10.1016/j.neuroscience.2016.02.037</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Dankoski E.C., Carroll S. and Wightman R.M. Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release. J. Neurochem. 2016;136: 1131- 1141. https://doi.org/10.1111/jnc.13528</mixed-citation><mixed-citation xml:lang="en">Dankoski E.C., Carroll S. and Wightman R.M. Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release. J. Neurochem. 2016;136: 1131- 1141. https://doi.org/10.1111/jnc.13528</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dorszewska J., Florczak-Wyspianska J., Kowalska M. et al. Serotonin in Neurological Diseases InTech, 2017, https://doi.org/10.5772/intechopen.69035</mixed-citation><mixed-citation xml:lang="en">Dorszewska J., Florczak-Wyspianska J., Kowalska M. et al. Serotonin in Neurological Diseases InTech, 2017, https://doi.org/10.5772/intechopen.69035</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Igelstrom KM Preclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial design. Epilepsia. 2012;53(4):596-605. PMID: 22416943 https://doi.org/10.1111/j.1528-1167.2012.03427.x</mixed-citation><mixed-citation xml:lang="en">Igelstrom KM Preclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial design. Epilepsia. 2012;53(4):596-605. PMID: 22416943 https://doi.org/10.1111/j.1528-1167.2012.03427.x</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Faingold C.L., Tupal S., &amp; Randall M. Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor. Epilepsy Behav. 2011;22(2): 186-190. PMID: 21920504 https://doi.org/10.1016/j.brainres.2011.08.043</mixed-citation><mixed-citation xml:lang="en">Faingold C.L., Tupal S., &amp; Randall M. Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor. Epilepsy Behav. 2011;22(2): 186-190. PMID: 21920504 https://doi.org/10.1016/j.brainres.2011.08.043</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ghevariya V. [et al.] Carcinoid tumors of the gastrointestinal tract. South Med J. 2009;102(10):1032-1040.</mixed-citation><mixed-citation xml:lang="en">Ghevariya V. [et al.] Carcinoid tumors of the gastrointestinal tract. South Med J. 2009;102(10):1032-1040.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Herman S, ?kerfeldt T, Spjuth O, Burman J, Kultima K. Biochemical differences in cerebrospinal fluid between secondary progressive and relapsing-remitting multiple sclerosis. 2019;8:84. PMID: 30678351 https://doi.org/10.3390/cells8020084</mixed-citation><mixed-citation xml:lang="en">Herman S, ?kerfeldt T, Spjuth O, Burman J, Kultima K. Biochemical differences in cerebrospinal fluid between secondary progressive and relapsing-remitting multiple sclerosis. 2019;8:84. PMID: 30678351 https://doi.org/10.3390/cells8020084</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Homberg JR, Lesch KP. Looking on the bright side of serotonin transporter gene variation. Biol Psychiatry. 2011;69:513519. PMID: 21047622 https://doi.org/10.1016/j.biopsych.2010.09.024</mixed-citation><mixed-citation xml:lang="en">Homberg JR, Lesch KP. Looking on the bright side of serotonin transporter gene variation. Biol Psychiatry. 2011;69:513519. PMID: 21047622 https://doi.org/10.1016/j.biopsych.2010.09.024</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Homberg JR, Schubert D, Gaspar P. New perspectives on the neurodevelopmental effects of SSRIs. Trends Pharmacol Sci. 2010;31:60-65. PMID: 19963284 https://doi.org/10.1016/j.tips.2009.11.003</mixed-citation><mixed-citation xml:lang="en">Homberg JR, Schubert D, Gaspar P. New perspectives on the neurodevelopmental effects of SSRIs. Trends Pharmacol Sci. 2010;31:60-65. PMID: 19963284 https://doi.org/10.1016/j.tips.2009.11.003</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lesurtel M. [et al.] A role of serotonin in the hepatogastrointestinal tract: an old molecule for new perspectives. Cell Mol Life Sci., 2008;65(6):940-52. PMID: 18080089 https://doi.org/10.1007/s00018-007-7377-3</mixed-citation><mixed-citation xml:lang="en">Lesurtel M. [et al.] A role of serotonin in the hepatogastrointestinal tract: an old molecule for new perspectives. Cell Mol Life Sci., 2008;65(6):940-52. PMID: 18080089 https://doi.org/10.1007/s00018-007-7377-3</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Miller J.M., Kinnely E.L. et al. Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder, 2009;63(7):565-573. https://doi.org/10.1002/syn.20637</mixed-citation><mixed-citation xml:lang="en">Miller J.M., Kinnely E.L. et al. Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder, 2009;63(7):565-573. https://doi.org/10.1002/syn.20637</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sargin D., Jeoung H.-S., Goodfellow N.M. and Lambe, E.K. Serotonin regulation of the prefrontal cortex: cognitive relevance and the impact of developmental perturbation. ACS Chem. Neurosci. 2019;10: 3078- 3093. https://doi.org/10.1021/acschemneuro.9b00073</mixed-citation><mixed-citation xml:lang="en">Sargin D., Jeoung H.-S., Goodfellow N.M. and Lambe, E.K. Serotonin regulation of the prefrontal cortex: cognitive relevance and the impact of developmental perturbation. ACS Chem. Neurosci. 2019;10: 3078- 3093. https://doi.org/10.1021/acschemneuro.9b00073</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shah R., Courtiol E., Castellanos F.X., Teixeira C.M. Abnormal serotonin levels during perinatal development lead to behavioral deficits in adulthood. Frontiers in Behavioral Neuroscience. 2018, no. 12, Article 114, https://doi.org/10.3389/fnbeh.2018.00114</mixed-citation><mixed-citation xml:lang="en">Shah R., Courtiol E., Castellanos F.X., Teixeira C.M. Abnormal serotonin levels during perinatal development lead to behavioral deficits in adulthood. Frontiers in Behavioral Neuroscience. 2018, no. 12, Article 114, https://doi.org/10.3389/fnbeh.2018.00114</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang T, Kingwell E, De Jong HJ et al. Association between the use of selective serotonin reuptake inhibitors and multiple sclerosis disability progression. Pharmacoepidemiol Drug Saf. 2016;25:1150-1159. PMID: 27211481 https://doi.org/10.1002/pds.4031</mixed-citation><mixed-citation xml:lang="en">Zhang T, Kingwell E, De Jong HJ et al. Association between the use of selective serotonin reuptake inhibitors and multiple sclerosis disability progression. Pharmacoepidemiol Drug Saf. 2016;25:1150-1159. PMID: 27211481 https://doi.org/10.1002/pds.4031</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
