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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2021.5.HLTHCR.2</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-301</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Общественное здоровье, организация здравоохранения, история медицины</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Public health</subject></subj-group></article-categories><title-group><article-title>Исторические аспекты асептики и антисептики</article-title><trans-title-group xml:lang="en"><trans-title>Historical aspects of aseptics and antiseptics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4213-5379</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозов Артем Михайлович, кандидат медицинских наук, доцент кафедры общей хирургии, SPIN-код 6815-9332</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9657-8063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеев</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeev</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеев Алексей Николаевич, доктор медицинских наук, доцент, заведующий кафедры общей хирургии, SPIN-код 8817-0158.</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3145-9776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жуков</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жуков Сергей Владимирович, доктор медицинских наук, профессор кафедры общественного здоровья и здравоохранения, SPIN-код 7604-1244</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4839-0311</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варпетян</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Varpetyan</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Варпетян Ани Мнацакановна, студентка 3 курса лечебного факультета</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8572-4862</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыжова</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryzhova</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рыжова Таисия Сергеевна, студентка 6 курса лечебного факультета, SPIN-код: 3725-7786</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0942-4614</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муравлянцева</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Muravlyantseva</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Муравлянцева Мария Михайловна, студентка 6 курса лечебного факультета, SPIN-код: 9386-4206</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8507-5447</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джафаров</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Jafarov</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джафаров Валех Тельманович, студент 5 курса лечебного факультета</p><p>Тверь</p></bio><bio xml:lang="en"><p>Tver</p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тверской государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tver State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>12</day><month>10</month><year>2021</year></pub-date><volume>0</volume><issue>6</issue><fpage>94</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Морозов А.М., Сергеев А.Н., Жуков С.В., Варпетян А.М., Рыжова Т.С., Муравлянцева М.М., Джафаров В.Т., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Морозов А.М., Сергеев А.Н., Жуков С.В., Варпетян А.М., Рыжова Т.С., Муравлянцева М.М., Джафаров В.Т.</copyright-holder><copyright-holder xml:lang="en">Morozov A.M., Sergeev A.N., Zhukov S.V., Varpetyan A.M., Ryzhova T.S., Muravlyantseva M.M., Jafarov V.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/301">https://vestnik.reaviz.ru/jour/article/view/301</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. На протяжении многих веков инфекционные осложнения являются одной из наиболее актуальных проблем хирургической практики. В современной медицине представлен широкий спектр методов асептики и антисептики, которые без вреда для организма позволяют уничтожить патогенные микроорганизмы и предупредить развитие гнойных осложнений, значительно отягощающих состояние пациента и увеличивающих сроки лечения. Однако, так было не всегда. В эру становления хирургии вмешательства в значительном большинстве случаев завершались развитием гнойных и септических осложнений, неминуемо приводивших к летальному исходу.</p><p>Целью настоящего исследования явилось изучение основных моментов, играющих ключевую роль в истории становления современной асептики и антисептики.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В ходе исследования был проведен анализ отечественной и иностранной литературы на тему истории развития асептики и антисептики. При составлении работы применялся биографический метод исторического исследования. В качестве материалов также были использованы статьи и исторические очерки периода описываемых событий.</p></sec><sec><title>Результаты</title><p>Результаты. Формирование принципов асептики и антисептики – это продолжительный исторический процесс, в который были вовлечены многие величайшие умы человечества. При этом, как и развитие любого научного мировоззрения, развитие асептики и антисептики базировалось на предшествующих знаниях, а также на знаниях, полученных, главным образом, эмпирическим путем. С незапамятных времен врачеватели уже имели представление об антибактериальных свойствах ряда соединений. Первые упоминания о попытках предупреждения загрязнения ран и их обеззараживания приходятся на времена Гиппократа. В средние века с целью обеззараживания ран широко использовали прижигания раскалённым железом, кипящим маслом. С середины XVIII века в практику хирургов вошли первые антисептики. С середины XIX века значительный вклад в развитие асептики и антисептики внесли русский хирург Н.И. Пирогов и его последователь Н.В. Склифосовский. Прорывом в развитии асептики и антисептики в конце XIX – начале XX веков стало научное открытие французского научного деятель Луи Пастера, который доказал, что процессы брожения и гниения вызываются микроорганизмами. Данное открытие легло в основу антисептического метода Дж. Листера. В конце XIX века Э. фон Бергманн разработал асептический метод. В 1900 г. англичанин C. Дж. Хантер дополнил асептику применением стерильных лицевых масок, которые позволили снизить воздушно-капельную контаминацию ран путем ограничения выделения капель секрета дыхательных путей хирурга во внешнюю среду. Лицевые маски показали высокую эффективность, и в современной хирургической практике данная мера асептики является рутинной. Одним из последних значимых событий в истории антисептики стало открытие А. Флемингом антибиотиков.</p></sec><sec><title>Выводы</title><p>Выводы. Благодаря деятельности великих ученых и врачей множество опасных послеоперационных осложнений, которые уносили жизни людей, если и не остались в прошлом, то их встречаемость и интенсивность проявлений заметно снизилась, а асептика и антисептика стали неотъемлемым компонентом хирургической практики.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. For many centuries, infectious complications have been one of the most pressing problems of surgical practice. In modern medicine, a wide range of aseptic and antiseptic methods is presented, which, without harm to the body, can destroy pathogenic microorganisms and prevent the development of purulent complications that significantly aggravate the patient's condition and increase the duration of treatment. However, this was not always the case. In the era of the formation of surgery, interventions in a significant majority of cases ended with the development of purulent and septic complications, which inevitably led to death.</p><p>The purpose of this study was to study the main points that play a key role in the history of the formation of modern asepsis and antiseptics.</p></sec><sec><title>Material and methods</title><p>Material and methods. In the course of the study, an analysis of domestic and foreign literature on the history of the development of aseptics and antiseptics was carried out. When compiling the work, the biographical method of historical research was used. Articles and historical sketches of the period of the described events were also used as materials.</p></sec><sec><title>Results</title><p>Results. The formation of the principles of asepsis and antisepsis is a long historical process in which many of the greatest minds of mankind have been involved. At the same time, like the development of any scientific worldview, the development of asepsis and antiseptics was based on previous knowledge, as well as on knowledge obtained, mainly empirically. From time immemorial, physicians have already had an idea of the antibacterial properties of a number of compounds. The first mentions of attempts to prevent contamination of wounds and their disinfection date back to the time of Hippocrates. In the Middle Ages, for the purpose of disinfecting wounds, cauterization with a red-hot iron and boiling oil was widely used. From the middle of the 18th century, the first antiseptics entered the practice of surgeons. From the middle of the 19th century, a significant contribution to the development of asepsis and antiseptics was made by the Russian surgeon N.I. Pirogov, and his follower N.V. Sklifosovsky. A breakthrough in the development of asepsis and antiseptics in the late 19th – early 20th centuries was the scientific discovery of the French scientist Louis Pasteur, who proved that the processes of fermentation and decay are caused by microorganisms. This discovery formed the basis of J. Lister's antiseptic method. At the end of the 19th century, E. von Bergmann developed the aseptic method. One of the last significant events in the history of antiseptics was A. Fleming antibiotics.</p></sec><sec><title>Conclusions</title><p>Conclusions. Thanks to the work of great scientists and doctors, there are many life-threatening postoperative complications that claimed the lives of many people, if they did not remain in the past, then their incidence and intensity of manifestations have noticeably decreased, and asepsis and antiseptics have become an integral component of surgical practice.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>асептика</kwd><kwd>антисептика</kwd><kwd>хирургическая инфекция</kwd><kwd>Гиппократ</kwd><kwd>Пирогов Николай Иванович</kwd><kwd>Игнац Филипп Земмельвейс</kwd><kwd>Луи Пастер</kwd><kwd>Джозеф Листер</kwd><kwd>Эрнст фон Бергманн</kwd><kwd>Александр Флеминг</kwd></kwd-group><kwd-group xml:lang="en"><kwd>asepsis</kwd><kwd>antiseptics</kwd><kwd>surgical infection</kwd><kwd>Hippocrates</kwd><kwd>Nikolai Ivanovich Pirogov</kwd><kwd>Ignaz Philip Semmelweis</kwd><kwd>Louis Pasteur</kwd><kwd>Joseph Lister</kwd><kwd>Ernst von Bergmann</kwd><kwd>Alexander Fleming</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проводилось без спонсорской поддержки.</funding-statement><funding-statement xml:lang="en">This research received no external funding.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bojko S.S., CHebykina V.I., SHlepotina N.M. 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