vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2022.1.CLIN.3vmireaviz-313Research ArticleКлиническая медицинаClinical medicineРоль адипонектина и лептина в развитии метаболического синдрома и связанных с ним ожирением и сахарным диабетом II типаRole of adiponektin and leptin in the development of metabolic syndrome and related obesity and type II diabetes mellitushttps://orcid.org/0000-0002-4827-6124ШевченкоЕ. А.ShevchenkoE. A.

Шевченко Елена Александровна, доктор медицинских наук, доцент, профессор кафедры патологической физиологии

SPIN-код: 9181-8989, AuthorID: 630714

Нижний Новгород

Nizhny Novgorod

el.shevchenko2010@yandex.ruhttps://orcid.org/0000-0001-7228-344XПотеминаТ. Е.PoteminaT. E.

Потемина Татьяна Евгеньевна, доктор медицинских наук, профессор, заведующая кафедрой патологической физиологии

SPIN-код: 2405-8059, AuthorID: 553848

Нижний Новгород

Nizhny Novgorod

tat_potemina@mail.ruhttps://orcid.org/0000-0002-1927-7662УспенскийА. Н.UspenskyA. N.

Успенский Александр Николаевич, доктор биологических наук, профессор кафедры физиологии, биохимии с.-х. животных и акушерства

SPIN-код: 3427-0837, AuthorID: 115448

Нижний Новгород

Nizhny Novgorod

alex-usp2015@yandex.ruПриволжский исследовательский медицинский университетРоссияPrivolzhsky Research Medical UniversityRussian FederationПриволжский исследовательский медицинский университетРоссияNizhny Novgorod State Agricultural AcademyRussian FederationНижегородская государственная сельскохозяйственная академияРоссияNizhny Novgorod State Agricultural AcademyRussian Federation202215092021012937Copyright © Шевченко Е.А., Потемина Т.Е., Успенский А.Н., 20222022Шевченко Е.А., Потемина Т.Е., Успенский А.Н.Shevchenko E.A., Potemina T.E., Uspensky A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/313

С каждым годом численность людей, страдающих метаболическим синдромом, неуклонно растет. Связанные с ним ожирение, сахарный диабет II типа в настоящее время находятся среди самых распространенных заболеваний. Цитокины, продуцируемые жировой тканью, выполняют роль регуляторов в обмене веществ, при ожирении происходит изменение в их секреции и нарушается баланс, что приводит к развитию инсулинорезистентности, а в дальнейшем – метаболическому синдрому и сахарному диабету II типа. Изучение механизмов влияния адипокинов, в частности адипонектина и лептина, на энергетический, углеводный и липидный обмен представляют наибольший интерес в связи с их ключевой ролью в развитии метаболических нарушений.

Every year the number of people suffering from metabolic syndrome is growing steadily. Associated obesity, type II diabetes mellitus is currently among the most common diseases. Cytokines produced by adipose tissue play the role of regulators in metabolism, with obesity, a change in their secretion occurs and the balance is disturbed, which leads to the development of insulin resistance, and later – metabolic syndrome and type II diabetes mellitus. The study of the mechanisms of the influence of adipokines, in particular adiponectin and leptin, on energy, carbohydrate and lipid metabolism are of greatest interest due to their key role in the development of metabolic disorders.

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The authors declare that there are no conflicts of interest present.