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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2021.5.MORPH.1</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-318</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Морфология, патология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Morphology, pathology</subject></subj-group></article-categories><title-group><article-title>Электронно-микроскопические особенности изменений в надпочечниках и щитовидной железе при хронической гипоксии</article-title><trans-title-group xml:lang="en"><trans-title>Electron-microscopic features of changes in the adrenal and thyroid glands in chronic hypoxia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6794-7798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ягубова</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Yagubova</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ягубова Самира Магомедгасан, кандидат медицинских наук, старший преподаватель кафедры патологической анатомии</p><p>Баку</p></bio><bio xml:lang="en"><p> Baku </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Азербайджанский медицинский университет</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>Azerbaijan medical university</institution><country>Azerbaijan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>20</day><month>09</month><year>2021</year></pub-date><volume>11</volume><issue>5</issue><fpage>42</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ягубова С.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ягубова С.М.</copyright-holder><copyright-holder xml:lang="en">Yagubova S.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/318">https://vestnik.reaviz.ru/jour/article/view/318</self-uri><abstract><p>Целью исследования было изучение характерных свойств ультраструктурных изменений в клеточном и внеклеточном матриксе надпочечников и щитовидной железы при хронической гипоксии.</p><sec><title>Материалы и методы</title><p>Материалы и методы. В ходе исследования использовали щитовидную и надпочечную железу здоровых взрослых самцов белых крыс массой 180–200 г. Применялись анатомические, гистологические, гистохимические, электронно-микроскопические и морфометрические методы исследования.</p></sec><sec><title>Результаты</title><p>Результаты. Мы обнаружили, что реакция клеток щитовидной железы и надпочечников на гипоксию различна. Так, поскольку процессы пролиферации в клетках щитовидной железы происходят быстрее и раньше, все ткани в щитовидной железе восстанавливаются на 15-й день эксперимента, а в надпочечнике – только на 30-й день. Это можно расценивать как более высокую степень чувствительности надпочечников к гипоксии, которая является более сильным стрессовым фактором, чем для щитовидной железы.</p></sec><sec><title>Выводы</title><p>Выводы. Структуры щитовидной железы более быстро адаптируются к длительной гипоксии и отвечают на это ультраструктурной перестройкой – гиперплазией, гипертрофией и пролиферацией тироцитов.</p></sec></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to study the characteristic features of ultrastructural changes in the cellular and extracellular matrix of the adrenal and thyroid glands in chronic hypoxia.</p><sec><title>Materials and methods</title><p>Materials and methods. The study used the thyroid and adrenal glands of healthy adult male white rats weighing 180-200 g. The anatomical, histological, histochemical, electron microscopic and morphometric methods were used.</p></sec><sec><title>Results</title><p>Results. We found that the response of thyroid and adrenal cells to hypoxia is different. So, since the processes of proliferation in the cells of the thyroid gland occur faster and earlier, all tissues are restored on the 15th day of the experiment in the thyroid gland, and in the adrenal gland are restored only on the 30th day of the experiment. And this can be regarded as a higher degree of sensitivity of the adrenal glands to hypoxia, which is a stronger stress factor than the thyroid gland.</p></sec><sec><title>Summary</title><p>Summary. The structures of the thyroid gland adapt to long-term hypoxia earlier, and responds to this with ultrastructural rearrangement – hyperplasia, hypertrophy and proliferation of thyrocytes.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>электронная микроскопия</kwd><kwd>хроническая гипоксия</kwd><kwd>корковое и мозговое вещество надпочечников</kwd><kwd>фолликулы и тиреоциты щитовидной железы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>electron microscopy</kwd><kwd>chronic hypoxia</kwd><kwd>cortical and medullary substance of the adrenal glands</kwd><kwd>follicles and thyrocytes of thyroid gland</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ivanov K.P. Sovremennye fundamental’nye problemy kislorodnogo transporta i gipoksii. Farmakoterapiya gipoksii i ee posledstviy pri kriticheskikh sostoyaniyakh. St. Petersburg. 2004:29-30. 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