vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2021.6.PHYS.1vmireaviz-343Research ArticleФизиологияPhysiologyДефицит кобаламина и патогенез неврологических нарушенийCobalamin deficiency and pathogenesis of neurological disordershttps://orcid.org/0000-0001-9579-2925ПерешеинА. В.PeresheinA. V.

Перешеин Андрей Владимирович, ассистент кафедры патологической физиологии 

Нижний Новгород 

Nizhny Novgorod

extern-group@yandex.ruhttps://orcid.org/0000-0003-1211-1720КузнецоваС. В.KuznetsovaS. V.

Кузнецова Светлана Вадимовна, кандидат медицинских наук, доцент кафедры патологической физиологии

Нижний Новгород 

Nizhny Novgorod

extern-group@yandex.ruhttps://orcid.org/0000-0001-7228-344XПотеминаТ. Е.PoteminaT. E.

Потемина Татьяна Евгеньевна, доктор медицинских наук, профессор, заведующий кафедры патологической физиологии

Нижний Новгород 

Nizhny Novgorod

extern-group@yandex.ruПриволжский исследовательский медицинский университетРоссияPrivolzhsky Research Medical UniversityRussian Federation202121112021062132Copyright © Перешеин А.В., Кузнецова С.В., Потемина Т.Е., 20212021Перешеин А.В., Кузнецова С.В., Потемина Т.Е.Pereshein A.V., Kuznetsova S.V., Potemina T.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/343

Рассмотрены вопросы специфического значения витаминов группы В для нервной системы, механизмы транспорта и метаболические функции кобаламина, патогенетические теории, связанные с дефицитом витамина B12: каноническая биохимическая и теория дисрегуляции цитокинов и факторов роста; затронута гипергомоцистеинемическая составляющая болезни мелких сосудов головного мозга – одной из наиболее распространенных форм дегенеративных расстройств центральной нервной системы; описаны типы нарушений, связанные с дефицитом кобаламина, лежащие в основе его неврологических проявлений.

The brief review deals with the specific value of B vitamins for the nervous system, the mechanisms of transport and metabolic functions of cobalamin, pathogenetic theories related to vitamin B12 deficiency such as canonical biochemical theory and the theory of dysregulation of cytokines and growth factors; the hyperhomocysteinemic component of cerebral small vessel disease as one of the most common types of degenerative disorders of the central nervous system has been mentioned; the types of disorders associated with cobalamin deficiency that underlie its neurological manifestations have been described.

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The authors declare that there are no conflicts of interest present.