vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2022.6.ICTM.1vmireaviz-532Research ArticleИнформационно-вычислительные технологии в медицинеInformation technology in medicineМатематическое моделирование кинетики однократного приема этанолаMathematical modeling of the kinetics of a single intake of ethanolhttps://orcid.org/0000-0002-7380-3766НедуговГ. В.NedugovG. V.

Недугов Герман Владимирович, доктор медицинких наук, доцент кафедры судебной медицины

eLibrary SPIN: 3828-8091

Самара

Samara

nedugovh@mail.ruСамарский государственный медицинский университетРоссияSamara State Medical UniversityRussian Federation202229102022126148156Copyright © Недугов Г.В., 20232023Недугов Г.В.Nedugov G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/532

Цель исследования: построение кинетического уравнения элиминации этанола нулевого порядка с абсорбцией первого порядка, учитывающего безвозвратный дефицит абсорбции этанола, с возможностью определения погрешностей оценки параметров модели, а также реализация модели в формате компьютерной программы. Выполнено аналитическое математическое моделирование кинетики однократного перорального приёма этанола. Разработана математическая модель кинетики однократного приема этанола с его элиминацией нулевого порядка, абсорбцией и пресистемным метаболизмом первого порядка. Предложен метод оценки предельных абсолютных погрешностей кинетических параметров построенной модели на основе суммирования парциальных вкладов исходных физических величин. Комплекс разработанных вычислительных процедур реализован в формате компьютерной программы «Alcohol Calculator V 1.0». Сделан вывод о целесообразности использования разработанной информационно-вычислительной технологии при судебно-медицинской экспертной оценке острой алкогольной интоксикации.

The aim of the study is to construct a kinetic equation of zero-order ethanol elimination with first-order absorption, taking into account the presystemic metabolism of ethanol, with the possibility of determining the errors in estimating the parameters of the model, as well as the implementation of the model in the format of a computer program. Analytical mathematical modeling of the kinetics of a single oral intake of ethanol has been performed. A mathematical model of the kinetics of a single intake of ethanol with its zero-order elimination, absorption and first-order presystemic metabolism has been developed. A method is proposed for estimating the limiting absolute errors of the kinetic parameters of the constructed model based on the summation of the partial contributions of the initial physical quantities. The complex of the developed computational procedures is implemented in the format of the «Alcohol Calculator V 1.0» computer program. The conclusion is made about the expediency of using the developed information and computing technology in the forensic medical expert assessment of acute alcohol intoxication.

фармакокинетика этаноламатематическое моделированиекинетическое уравнениепресистемный метаболизмpharmacokinetics of ethanolmathematical modelingkinetic equationpresystemic metabolismReferencesReiter GS, Boeckle M, Reiter C, Seltenhammer MH. The impact of total body water on breath alcohol calculations. Wien Klin Wochenschr. 2020;132(17-18):535-541. https://doi.org/10.1007/s00508-020-01663-4Reiter GS, Boeckle M, Reiter C, Seltenhammer MH. The impact of total body water on breath alcohol calculations. Wien Klin Wochenschr. 2020;132(17-18):535-541. https://doi.org/10.1007/s00508-020-01663-4Himemiya-Hakucho A, Fujimiya T. Pharmacokinetic analyses using absorption kinetics in low-alcohol dose cases of drunken driving. Leg Med (Tokyo). 2017;26:98-101. https://doi.org/10.1016/j.legalmed.2017.05.002Himemiya-Hakucho A, Fujimiya T. Pharmacokinetic analyses using absorption kinetics in low-alcohol dose cases of drunken driving. Leg Med (Tokyo). 2017;26:98-101. https://doi.org/10.1016/j.legalmed.2017.05.002Iffland R, Jones AW. Evaluating alleged drinking after driving--the hip-flask defence. Part 1. Double blood samples and urine-to-blood alcohol relationship. Med Sci Law. 2002;42(3):207-24. https://doi.org/10.1177/002580240204200305Iffland R, Jones AW. Evaluating alleged drinking after driving--the hip-flask defence. Part 1. Double blood samples and urine-to-blood alcohol relationship. Med Sci Law. 2002;42(3):207-24. https://doi.org/10.1177/002580240204200305Simic M, Tasic M. The relationship between alcohol elimination rate and increasing blood alcohol concentration--calculated from two consecutive blood specimens. Forensic Sci Int. 2007;172(1):28-32. https://doi.org/10.1016/j.forsciint.2006.11.008Simic M, Tasic M. The relationship between alcohol elimination rate and increasing blood alcohol concentration--calculated from two consecutive blood specimens. Forensic Sci Int. 2007;172(1):28-32. https://doi.org/10.1016/j.forsciint.2006.11.008Simic M, Tasic M, Stojiljkovic G, Budakov B, Vukovic R. "Cognac alibi" as a drunk-driving defense and medico-legal challenge. Med Law. 2004;23(2):367-78Simic M, Tasic M, Stojiljkovic G, Budakov B, Vukovic R. "Cognac alibi" as a drunk-driving defense and medico-legal challenge. Med Law. 2004;23(2):367-78Brouwer IG. The Widmark formula for alcohol quantification. SADJ. 2004;59(10):427-8.Brouwer IG. The Widmark formula for alcohol quantification. SADJ. 2004;59(10):427-8.Searle J. Alcohol calculations and their uncertainty. Med Sci Law. 2015;55(1):58-64. https://doi.org/10.1177/0025802414524385Searle J. Alcohol calculations and their uncertainty. Med Sci Law. 2015;55(1):58-64. https://doi.org/10.1177/0025802414524385Posey D, Mozayani A. The estimation of blood alcohol concentration: Widmark revisited. Forensic Sci Med Pathol. 2007;3(1):33-9. https://doi.org/10.1385/FSMP:3:1:33Posey D, Mozayani A. The estimation of blood alcohol concentration: Widmark revisited. Forensic Sci Med Pathol. 2007;3(1):33-9. https://doi.org/10.1385/FSMP:3:1:33Martin E, Moll W, Schmid P, Dettli L. The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion. Eur J Clin Pharmacol. 1984;26(5):619-26. https://doi.org/10.1007/BF00543496Martin E, Moll W, Schmid P, Dettli L. The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion. Eur J Clin Pharmacol. 1984;26(5):619-26. https://doi.org/10.1007/BF00543496Wedel M, Pieters JE, Pikaar NA, Ockhuizen T. Application of a three-compartment model to a study of the effects of sex, alcohol dose and concentration, exercise and food consumption on the pharmacokinetics of ethanol in healthy volunteers. Alcohol Alcohol. 1991;26(3):329-36. https://doi.org/10.1093/oxfordjournals.alcalc.a045119Wedel M, Pieters JE, Pikaar NA, Ockhuizen T. Application of a three-compartment model to a study of the effects of sex, alcohol dose and concentration, exercise and food consumption on the pharmacokinetics of ethanol in healthy volunteers. Alcohol Alcohol. 1991;26(3):329-36. https://doi.org/10.1093/oxfordjournals.alcalc.a045119Jiang Y, Zhang T, Kusumanchi P, Han S, Yang Z, Liangpunsakul S. Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines. 2020;8(3):50. https://doi.org/10.3390/biomedicines8030050Jiang Y, Zhang T, Kusumanchi P, Han S, Yang Z, Liangpunsakul S. Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines. 2020;8(3):50. https://doi.org/10.3390/biomedicines8030050Seidl S, Jensen U, Alt A. The calculation of blood ethanol concentrations in males and females. Int J Legal Med. 2000;114(1-2):71-7. https://doi.org/10.1007/s004140000154Seidl S, Jensen U, Alt A. The calculation of blood ethanol concentrations in males and females. Int J Legal Med. 2000;114(1-2):71-7. https://doi.org/10.1007/s004140000154

The authors declare that there are no conflicts of interest present.