vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2022.6.TX.1vmireaviz-613Research ArticleТрансплантация органов и тканейOrgan and tissue transplantationПервый опыт трансплантации печени ВИЧ-позитивным пациентам в РоссииFirst experience of liver transplantation for HIV-positive patients in Russiahttps://orcid.org/0000-0002-6362-7914НоврузбековМ. С.NovruzbekovM. S.

Новрузбеков Мурад Сафтарович, руководитель научного отделения трансплантации печени; заведующий кафедрой трансплантологии и искусственных органов

Москва

Moscow

https://orcid.org/0000-0001-8650-0855ГуляевВ. А.GulyaevV. A.

Гуляев Владимир Алексеевич, старший научный сотрудник отделения трансплантации печени

Москва

Moscow

https://orcid.org/0000-0003-2581-1443МазусА. И.MazusA. I.

Мазус Алексей Израилевич, руководитель Московского городского центра профилактики и борьбы со СПИДом, главный внештатный специалист по ВИЧ-инфекции Министерства здравоохранения Российской Федерации и Департамента здравоохранения города Москвы

Москва

Moscow

https://orcid.org/0000-0003-4981-0824ИванниковЕ. В.IvannikovE. V.

Иванников Евгений Васильевич, заведующий поликлиническим отделением

Москва

Moscow

https://orcid.org/0000-0002-9649-8522ЯдрихинскаяМ. С.YadrikhinskayaM. S.

Ядрихинская Марина Сергеевна, врач-инфекционист

Москва 

Moscow

https://orcid.org/0000-0003-2305-4055ЛуцыкК. Н.LutsykK. N.

Луцык Константин Николаевич, заведующий отделением трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0002-0691-5581ОлисовО. Д.OlisovO. D.

Олисов Олег Даниелович, старший научный сотрудник отделения трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0003-1117-7883АхметшинР. Б.AkhmetshinR. B.

Ахметшин Равиль Борисович, врач-хирург отделения трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0002-5057-6628МагомедовК. М.MagomedovK. M.

Магомедов Кубай Магомедович, научный сотрудник отделения трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0001-5723-4818КазымовБ. И.KazymovB. I.

Казымов Бахтияр Исметович, научный сотрудник отделения трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0001-6604-0927АхмедовА. Р.AkhmedovA. R.

Ахмедов Амир Русланович, научный сотрудник отделения трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0002-2264-7038АлекберовК. Ф.AlekberovK. F.

Алекберов Кямран Файгович, научный сотрудник отделения трансплантации печени

Москва 

Moscow

https://orcid.org/0000-0001-5889-8675ЯреминБ. И.YareminB. I.

Яремин Борис Иванович, научный сотрудник отделения трансплантации печени; доцент кафедры трансплантологии и искусственных органов

Москва 

Moscow

b.i.yaremin@reaviz.onlineНаучно-исследовательский институт скорой помощи им. Н.В. Склифосовского; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияSklifosovsky Research Institute of Emergency Medicine; Pirogov Russian National Research Medical UniversityRussian FederationНаучно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute of Emergency MedicineRussian FederationМосковский городской центр профилактики и борьбы со СПИДомРоссияMoscow City AIDS CenterRussian Federation202228122022126139147Copyright © Новрузбеков М.С., Гуляев В.А., Мазус А.И., Иванников Е.В., Ядрихинская М.С., Луцык К.Н., Олисов О.Д., Ахметшин Р.Б., Магомедов К.М., Казымов Б.И., Ахмедов А.Р., Алекберов К.Ф., Яремин Б.И., 20232023Новрузбеков М.С., Гуляев В.А., Мазус А.И., Иванников Е.В., Ядрихинская М.С., Луцык К.Н., Олисов О.Д., Ахметшин Р.Б., Магомедов К.М., Казымов Б.И., Ахмедов А.Р., Алекберов К.Ф., Яремин Б.И.Novruzbekov M.S., Gulyaev V.A., Mazus A.I., Ivannikov E.V., Yadrikhinskaya M.S., Lutsyk K.N., Olisov O.D., Akhmetshin R.B., Magomedov K.M., Kazymov B.I., Akhmedov A.R., Alekberov K.F., Yaremin B.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/613

В статье представлены результаты выполнения трансплантации печени пяти ВИЧ-инфицированным реципиентам с необратимым поражением печени. Показано, что в отдалённом периоде выжило и наблюдаются в стабильном состоянии четверо из них, причём единственная смерть у реципиента не была связана с ВИЧ-инфекцией. Обобщён опыт лечения данных пациентов. Анализ первых результатов выполнения трансплантации печени при ВИЧ-инфекции в России показывает обоснованность и её клиническую эффективность. Единственный летальный случай связан с исходно крайне тяжёлым состоянием реципиента и его возрастом. Два случая операционного травматизма, отсутствие последовательной вакцинации в предоперационном периоде, а также отсутствие пациентов с гепатоцеллюлярным раком, малое число наблюдений являются явными недостатками нашего первого опыта и должны быть скорректированы в дальнейшем. Успех реализации сложной и мультидисциплинарной программы трансплантации органов при ВИЧ-инфекции невозможен без участия ВИЧ-инфекционистов в трансплантационной команде.

The article presents the results of liver transplantation in five HIV-infected recipients with irreversible liver damage. It is shown that four of them survived in the long-term period and are observed in a stable condition, and the only death in the recipient was not related to the HIV infection. The experience in the treatment of these patients was summarized. Analysis of the first results of liver transplantation in HIV-infection in Russia shows its validity and clinical efficacy. The only lethal case is connected with the initial extremely grave condition of the recipient and his age. Two cases of surgical traumatism, lack of consistent vaccination in the preoperative period, as well as lack of patients with hepatocellular cancer, small number of observations are obvious drawbacks of our first experience and should be corrected in the future. The success of a complex and multidisciplinary program of organ transplantation in HIV infection is impossible without participation of HIV-infectionists in the transplantation team.

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The authors declare that there are no conflicts of interest present.