vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2023.1.TX.1vmireaviz-629Research ArticleДонорство и трансплантация органов и тканейOrgan and tissue donation and transplantationНесостоятельности трансплантата у реципиентов аллогенных гемопоэтических стволовых клеток: диагностика и лечениеGraft failure in allogeneic hematopoietic stem cell recipients: diagnosis and treatmenthttps://orcid.org/0000-0002-3009-4744МасликоваУ. В.MaslikovaU. V.

Масликова Ульяна Владиславовна, врач-гематолог отделения химиотерапии гемобластозов и трансплантации костного мозга и гемопоэтических стволовых клеток,

Москва

Moscow

maslikova.ulyana@outlook.comhttps://orcid.org/0000-0003-0636-4991ПоповаН. Н.PopovaN. N.

Попова Наталья Николаевна, врач-гематолог отделения химиотерапии гемобластозов и трансплантации костного мозга и гемопоэтических стволовых клеток; научный сотрудник сектора научных исследований химиотерапии гемобластозов, депрессий кроветворения и ТКМ, кандидат медицинских наук,

Москва

Moscow

nn_work15@mail.ruhttps://orcid.org/0000-0001-9431-8316ДроковМ. Ю.DrokovM. Yu.

Дроков Михаил Юрьевич, руководитель сектора научных исследований химиотерапии гемобластозов, депрессий кроветворения и ТКМ, врач-гематолог, кандидат медицинских наук,

Москва

Moscow

mdrokov@gmail.comhttps://orcid.org/0000-0002-0110-3314ХамагановаЕ. Г.KhamaganovaE. G.

Хамаганова Екатерина Георгиевна, доктор биологических наук, заведующая лабораторией тканевого типирования,

Москва

Moscow

ekhamag@mail.ruНациональный медицинский исследовательский центр гематологииРоссияNational Medical Research Center of HematologyRussian Federation202314012023131114125Copyright © Масликова У.В., Попова Н.Н., Дроков М.Ю., Хамаганова Е.Г., 20232023Масликова У.В., Попова Н.Н., Дроков М.Ю., Хамаганова Е.Г.Maslikova U.V., Popova N.N., Drokov M.Y., Khamaganova E.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/629

Несостоятельность трансплантата – группа осложнений после трансплантации аллогенных гемопоэтических стволовых клеток, которая встречается по разным данным до 30 % случаев. В группу осложнений входят первичная и вторичная несостоятельность трансплантата, первичная, вторичная и транзиторная гипофункция трансплантата и отторжение трансплантата. Сложности диагностики заключаются в отсутствии единых критериев, принятых в трансплантационном сообществе, и в двоякой интерпретации этих осложнений по данным иностранной литературы. Целью данного обзора литературы было определить наиболее часто встречающиеся критерии различных видов несостоятельности трансплантата и тактику диагностики и лечения. В обзоре мы проанализировали данные различных источников литературы, дали определения несостоятельности и гипофункции трансплантата, проанализировали литературные данные по применяемым методам лечения данных состояний.

Graft failure is a group of complications after allogeneic hematopoietic stem cell transplantation, which occurs according to different data up to 30%. The group of complications includes primary and secondary graft failure, primary, secondary and transient poor graft function and graft rejection. Diagnostic difficulties consist in the lack of unified diagnostic criteria accepted in the transplantation community and in the dual interpretation of these complications according to the foreign literature. The purpose of this literature review was to identify the most common criteria of different types of graft failure and determine the tactics of diagnosis and treatment. In this review we analyzed data from various literature sources, gave definitions of graft failure and poor graft function. We analyzed the literature data on the methods used to treat these conditions.

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The authors declare that there are no conflicts of interest present.