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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2023.1.MORPH.3</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-658</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Морфология, патология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Morphology, pathology</subject></subj-group></article-categories><title-group><article-title>Новый подход к патогенезу и лечению трофических язв</article-title><trans-title-group xml:lang="en"><trans-title>New approach to pathogenesis and treatment of trophycal ulcers</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6981-2717</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мусаева</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Musayeva</surname><given-names>Arzu M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мусаева Арзу Мисирровна, врач-терапевт Вклад в статью 100 % – разработка концепции, проведение исследования, анализ полученных результатов, подготовка статьи </p></bio><email xlink:type="simple">ittihaf@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр интегративных медицинских научных исследований Международной Академии Наук</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>Center for Integrative Medical Scientific Research of the International Academy of Sciences</institution><country>Azerbaijan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>02</month><year>2023</year></pub-date><volume>13</volume><issue>1</issue><fpage>27</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мусаева А.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Мусаева А.М.</copyright-holder><copyright-holder xml:lang="en">Musayeva A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/658">https://vestnik.reaviz.ru/jour/article/view/658</self-uri><abstract><p>Введение. Трофические язвы являются одним из наиболее распространенных медицинских заболеваний во всем мире. Лечение пациентов с трофическими язвами затруднено не только потому, что они часто рецидивируют, но и потому, что их трудно лечить. Цель: изучить клинические особенности и представить собственные результаты комбинированных методов лечения трофических язв венозной этиологии. Материалы и методы. В исследовании приняли участие 100 пациентов с трофическими язвами нижних конечностей венозной, диабетической и атеросклеротической этиологии, которые имели в анамнезе и проходили лечение по поводу варикозного расширения вен нижних конечностей и посттромботической болезни. Обследование пациентов включало анкетирование, уточнение жалоб, данных анамнеза, причин развития, осмотр и ультразвуковую диагностику (дуплексное обследование). Обследование язвы включало определение местоположения, размера, внешнего вида, основания раны, уровня экссудации и оценку состояния кожи вокруг дефекта. Результаты. Этиологическими факторами развития трофических язв были: варикозная болезнь с хронической венозной недостаточностью – 25 пациентов, посттромботическая болезнь – 55 пациентов. Всем пациентам проводилось только консервативное лечение трофических венозных язв с назначением композитума плаценты. После лечения группы из 100 пациентов с венозными трофическими язвами, 89 % были излечены в течение 4 месяцев, 8 % были излечены в течение 2 лет, а у 3 % язвы не заживали более двух лет. Средняя продолжительность течения язв составила 12 месяцев. Средний размер трофических язв по результатам анализа составил 8 см2. Полное заживление венозных язв чаще всего наблюдалось в возрастной группе 61–73 года – у 30 % пациентов. Заключение. Применение плаценты композитум способствовало ускорению заживления ран, что позволило получить более эффективные результаты. Ключевые слова: трофические язвы, варикозная болезнь с хронической венозной недостато</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Trophic ulcers are one of the most common medical ailments worldwide. Treatment of patients with trophic ulcers is difficult not only because they often recur, but also because they are difficult to treat. Purpose. Study the clinical features and present our own results of combined methods of treatment of trophic ulcers of venous etiology. Materials and methods. The study involved 100 patients with trophic ulcers of the lower extremities of venous, diabetic and atherosclerotic etiology, who had a history and were treated for varicose veins of the lower extremities and post-thrombotic disease. Examination of patients included questionnaires, clarification of complaints, anamnesis data, causes of development, examination and ultrasound diagnostics (duplex examination). The examination of the ulcer included determining the location, size, appearance, base of the wound, the level of exudation and assessment of the condition of the skin around the defect. Results. The etiological factors in the development of trophic ulcers were: varicose disease with chronic venous insufficiency – 25 patients, post-thrombotic disease – 55 patients. All patients underwent only conservative treatment of trophic venous ulcers with the appointment of a placenta compositum. After the treatment of a group of patients, out of 100 patients with venous trophic ulcers, 89% were cured within 4 months, 8% were cured within 2 years, and in 3 % ulcers did not heal for more than two years. The average duration of the course of ulcers was 12 months. The average size of trophic ulcers based on the results of the analysis was 8 cm2. Complete healing of venous ulcers was most often observed in the age group 61–73 years in 30% patients. Conclusion. The use of the compositum placenta contributed to the acceleration of wound healing, which made it possible to obtain more effective results.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>трофические язвы</kwd><kwd>варикозная болезнь с хронической венозной недостаточностью</kwd><kwd>посттромботическая болезнь</kwd><kwd>композитум плаценты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>trophic ulcers</kwd><kwd>varicose veins with chronic venous deficiency</kwd><kwd>posttrombotic disease</kwd><kwd>compositum placenta</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проводилось без спонсорской поддержки.</funding-statement><funding-statement xml:lang="en">This research received no external funding.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кривощёков Е.П., Яремин Б.И., Атаманов Е.В. 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