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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vmireaviz</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник медицинского института «РЕАВИЗ». Реабилитация, Врач и Здоровье</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-762X</issn><issn pub-type="epub">2782-1579</issn><publisher><publisher-name>РЕАВИЗ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/vmi-rvz.2023.2.TX.1</article-id><article-id custom-type="elpub" pub-id-type="custom">vmireaviz-660</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Трансплантация органов и тканей</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Organ and tissue transplantation</subject></subj-group></article-categories><title-group><article-title>Острое клеточное отторжение трансплантата почки у пациента африканского происхождения: клиническое наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0746-1884</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубутия</surname><given-names>М. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Khubutiya</surname><given-names>M. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хубутия Могели Шалвович, отделение трансплантации почки и поджелудочной железы, 129090, Москва, Большая Сухаревская площадь, 3;</p><p>кафедра трансплантологии и искусственных органов, 127473, Москва, Делегатская, 20, стр. 1;</p><p>Организационно-методический отдел по трансплантации, 115088, Москва, Шарикоподшипниковская, 9</p></bio><bio xml:lang="en"><p>Mogeli S. Khubutiya, Department of Kidney and Pancreas Transplantation, 3 Bolshaya SukharevskayaSquare, Moscow, 129090;</p><p>Department of Transplantology and Artificial Organs, 20, p. 1, Delegate, Moscow, 127473;</p><p>Organizational and methodological Department of transplantation, 9 Sharikopodshipnikovskaya, Moscow, 115088</p></bio><email xlink:type="simple">khubutiyams@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3259-4873</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александрова</surname><given-names>В. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleksandrova</surname><given-names>V. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александрова Вероника Олеговна, Отделение трансплантации почки и поджелудочной железы, </p><p>129090, Москва, Большая Сухаревская площадь, 3</p></bio><bio xml:lang="en"><p>Veronika O. Aleksandrova, Department of Kidney and Pancreas Transplantation,</p><p>3 Bolshaya Sukharevskaya Square, Moscow, 129090</p></bio><email xlink:type="simple">6878275@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1396-7048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балкаров</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Balkarov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балкаров Аслан Галиевич, Отделение трансплантации почки и поджелудочной железы,  129090, Москва, Большая Сухаревская площадь, 3;</p><p>кафедра трансплантологии и искусственных органов, 117997, Москва, Островитянова, 1;</p><p>Организационно-методический отдел по трансплантации, 115088, Москва, Шарикоподшипниковская, 9</p></bio><bio xml:lang="en"><p>Aslan G. Balkarov, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya Square, Moscow, 129090;</p><p>Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997;</p><p>Organizational and methodological Department of transplantation, 9 Sharikopodshipnikovskaya, Moscow, 115088</p></bio><email xlink:type="simple">Balkarovag@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0184-346X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виноградов</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinogradov</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виноградов Владимир Евгеньевич, Организационно-методический отдел по трансплантации, 115088, Москва, Шарикоподшипниковская, 9;</p><p>Консультативное диагностическое нефрологическое отделение, 123182, Москва, Пехотная, 3</p></bio><bio xml:lang="en"><p>Vladimir E. Vinogradov, Organizational and methodological Department of transplantation, 9 Sharikopodshipnikovskaya, Moscow, 115088;</p><p>Consultative and Diagnostic Nephrological Department, 3 Pekhotnaya, Moscow, 123182</p></bio><email xlink:type="simple">vino-gradoff@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2521-9565</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загородникова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagorodnikova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загородникова Наталья Валерьевна, Отделение трансплантации почки и поджелудочной железы,</p><p>129090, Москва, Большая Сухаревская площадь, 3</p></bio><bio xml:lang="en"><p>Natal'ya V. Zagorodnikova, Department of Kidney and Pancreas Transplantation,</p><p>3 Bolshaya Sukharevskaya Square, Moscow, 129090</p></bio><email xlink:type="simple">zagorodnikovanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7953-8182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сторожев</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Storozhev</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сторожев Роман Васильевич, Отделение трансплантации почки и поджелудочной железы,</p><p>129090, Москва, Большая Сухаревская площадь, 3</p></bio><bio xml:lang="en"><p>Roman V. Storozhev, Department of Kidney and Pancreas Transplantation,</p><p>3 Bolshaya Sukharevskaya Square, Moscow, 129090</p></bio><email xlink:type="simple">storozhevrv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8199-905X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмарина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmarina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шмарина Нонна Валерьевна, Отделение трансплантации почки и поджелудочной железы, 129090, Москва, Большая Сухаревская площадь, 3;</p><p>кафедра трансплантологии и искусственных органов, 117997, Москва, Островитянова, 1</p></bio><bio xml:lang="en"><p>Nonna V. Shmarina, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya Square, Moscow, 129090;</p><p>Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997</p></bio><email xlink:type="simple">shmarinanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8897-7523</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боровкова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Borovkova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Боровкова Наталья Валерьевна, кафедра трансплантологии и искусственных органов, 117997, Москва, Островитянова, 1;</p><p>Отделение биотехнологий и трансфузиологии, 129090, Москва, Большая Сухаревская площадь, 3</p></bio><bio xml:lang="en"><p>Natal'ya V. Borovkova, Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997;</p><p>Department of Biotechnology and Transfusiology, 3 Bolshaya Sukharevskaya Square, Moscow, 129090</p></bio><email xlink:type="simple">borovkovanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5731-3310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитриев Илья Викторович, Отделение трансплантации почки и поджелудочной железы, 129090, Москва, Большая Сухаревская площадь, 3;</p><p>кафедра трансплантологии и искусственных органов, 117997, Москва, Островитянова, 1</p></bio><bio xml:lang="en"><p>Il'ya V. Dmitriev, Department of Kidney and Pancreas Transplantation, 3 Bolshaya Sukharevskaya Square, Moscow, 129090;</p><p>Department of Transplantology and Artificial Organs, 1 Ostrovityanova, Moscow, 117997</p></bio><email xlink:type="simple">dmitrieviv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского; &#13;
Московский государственный медико-стоматологический университет имени А.И. Евдокимова;&#13;
Научно-исследовательский институт организации здравоохранения и медицинского менеджмента&#13;
Департамента здравоохранения города Москвы<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute of Emergency Medicine;&#13;
Moscow State Medical and Dental University named after A.I. Evdokimov;&#13;
Research Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute of Emergency Medicine<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского;&#13;
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова;&#13;
Научно-исследовательский институт организации здравоохранения и медицинского менеджмента Департамента здравоохранения города Москвы<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute of Emergency Medicine;&#13;
Pirogov Russian National Research Medical University;&#13;
Research Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Научно-исследовательский институт организации здравоохранения и медицинского менеджмента Департамента здравоохранения города Москвы;&#13;
Городская клиническая больница № 52 Департамента здравоохранения города Москвы<country>Россия</country></aff><aff xml:lang="en">Research Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow; City Clinical Hospital No. 52 of the Moscow City Health Department<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского;&#13;
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова<country>Россия</country></aff><aff xml:lang="en">N.V. Sklifosovsky Research Institute of Emergency Medicine;&#13;
Pirogov Russian National Research Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>13</day><month>02</month><year>2023</year></pub-date><volume>13</volume><issue>2</issue><fpage>112</fpage><lpage>116</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хубутия М.Ш., Александрова В.О., Балкаров А.Г., Виноградов В.Е., Загородникова Н.В., Сторожев Р.В., Шмарина Н.В., Боровкова Н.В., Дмитриев И.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Хубутия М.Ш., Александрова В.О., Балкаров А.Г., Виноградов В.Е., Загородникова Н.В., Сторожев Р.В., Шмарина Н.В., Боровкова Н.В., Дмитриев И.В.</copyright-holder><copyright-holder xml:lang="en">Khubutiya M.S., Aleksandrova V.O., Balkarov A.G., Vinogradov V.E., Zagorodnikova N.V., Storozhev R.V., Shmarina N.V., Borovkova N.V., Dmitriev I.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnik.reaviz.ru/jour/article/view/660">https://vestnik.reaviz.ru/jour/article/view/660</self-uri><abstract><p>Этническое происхождение реципиента относится к известным факторам, влияющим на исходы трансплантации почки. В статье представлен первый опыт трансплантации почки пациенту африканского происхождения в НИИ СП им. Н.В. Склифосовского.</p><sec><title>Материал и методы</title><p>Материал и методы. Аллогенная трансплантация почечного трансплантата от посмертного донора была выполнена пациенту африканского происхождения мужского пола 60 лет с хронической болезнью почек 5 стадии в исходе гипертонического нефроангиосклероза.</p></sec><sec><title>Результаты</title><p>Результаты. Ранний послеоперационный период осложнился развитием острого клеточного отторжения трансплантата 1a-b степени по Banff. Проведена противокризовая терапия с некоторым положительным эффектом, однако в отдалённом послеоперационном периоде была отмечена утрата функции почечного трансплантата, и пациент был возвращён на заместительную почечную терапию программным гемодиализом.</p></sec><sec><title>Заключение</title><p>Заключение. Пациенты африканского происхождения склонны к повышенному риску неблагоприятных исходов вследствие иммунологических причин и нуждаются в более тщательном иммунологическом подборе донорского органа, усиленной схеме иммуносупрессивной терапии и внимательном наблюдении после трансплантации. </p></sec></abstract><trans-abstract xml:lang="en"><p>The origin of the recipient is one of the recipient-related factors that statistically significantly affects the outcomes of kidney transplantation, but this factor is not so relevant in our country. The article presents the first experience of kidney transplantation in a patient of African descent at the N.I. N.V. Sklifosovsky.</p><sec><title>Material and methods</title><p>Material and methods. Allogeneic renal graft transplantation from a post-mortem donor was performed in a 60-year-old African male patient with stage 5 chronic kidney disease as a result of hypertensive nephroangiosclerosis.</p></sec><sec><title>Results</title><p>Results. The early postoperative period was complicated by the development of acute cellular graft rejection grade 1a-b according to Banff. Anti-crisis therapy was performed with some positive effect, however, in the late postoperative period, a loss of renal graft function was noted, and the patient was returned to renal replacement therapy with program hemodialysis.</p></sec><sec><title>Conclusion</title><p>Conclusion. Patients of African ancestry are at increased risk of adverse outcomes due to immunological causes and require more careful immunological selection of a donor organ, an enhanced immunosuppressive regimen, and close monitoring after transplantation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация почки</kwd><kwd>пациент африканского происхождения</kwd><kwd>острый криз отторжения</kwd><kwd>утрата трансплантата почки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>kidney transplantation</kwd><kwd>patient of African descent</kwd><kwd>acute rejection crisis</kwd><kwd>loss of a kidney transplant</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Knechtle SJ, Morris P. Kidney Transplantation – Principles and Practice: Expert Consult. 7th eds. Saunders; 2013.</mixed-citation><mixed-citation xml:lang="en">1 Knechtle SJ, Morris P. 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