vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2023.4.TX.1vmireaviz-781Research ArticleДонорство и трансплантация органов и тканейOrgan and tissue donation and transplantationВнепечёночные причины заболеваемости и смертности реципиентов печени в отдалённом посттрансплантационном периодеExtrahepatic causes of morbidity and mortality of liver recipients in the long-term posttransplantation periodhttps://orcid.org/0000-0001-5691-5398ВосканянС. Э.VoskanyanS. E.

Восканян Сергей Эдуардович - Член-корреспондент РАН, доктор медицинских наук, профессор, заместитель главного врача по хирургической помощи - руководитель Центра хирургии и трансплантологии.

Ул. Маршала Новикова, д. 23, Москва, 123098

Sergey Е. Voskanyan - Corresponding Member of the Russian Academy of Sciences, Prof., Dr. Sci. (Med.), Deputy Chief Physician for Surgical Care - Head of Surgery and Transplantation Center.

23 Marshal Novikov str., Moscow, 123098

voskanyan_se@mail.ruhttps://orcid.org/0000-0001-8391-5211СюткинВ. Е.SyutkinV. E.

Сюткин Владимир Евгеньевич - доктор медицинских наук, профессор кафедры хирургии с курсами онкохирургии, эндоскопии, хирургической патологии, клинической трансплантологии и органного донорства Медико-биологического университета инноваций и непрерывного образования. Ведущий научный сотрудник отделения трансплантации печени, НИИ скорой помощи им. Н.В. Склифосовского.

Ул. Маршала Новикова, д. 23, Москва, 123098; Большая Сухаревская пл., д. 3, Москва, 129090

Vladimir Е. Syutkin - Dr. Sci. (Med.), Professor of the Surgery Department with the Courses of Oncology, Anesthesiology and Resuscitation, Endoscopy, Surgical Pathology, Clinical Transplantation and Organ Donation, the Medical and Biological University of Innovation and Continuing Education, BFMBC; Leading Research Associate, Department for Liver Transplantation, N.V. Sklifosovsky RIEM.

23 Marshal Novikov str., Moscow, 123098; 3 Bolshaya Sukharevskaya Sq., Moscow, 129090

vladsyutkin@gmail.comhttps://orcid.org/0000-0002-1561-6268СушковА. И.SushkovA. I.

Сушков Александр Игоревич - кандидат медицинских наук, заведующий лабораторией новых хирургических технологий

Ул. Маршала Новикова, д. 23, Москва, 123098

Alexander I. Sushkov - Cand. Sci. (Med.), Head of Laboratory of New Surgical Technologies.

23 Marshal Novikov str., Moscow, 123098

sushkov.transpl@gmail.comhttps://orcid.org/0000-0003-2445-7382ВосканянЮ. В.VoskanyanYu. V.

Восканян Юлия Владимировна - врач-гастроэнтеролог поликлиники.

Ул. Маршала Новикова, д. 23, Москва, 123098

Yuliya V. Voskanyan - Gastroenterologist of the Out-patient Department.

23 Marshal Novikov str., Moscow, 123098

uvoskanyan@fmbcfmba.ruhttps://orcid.org/0000-0002-1135-7430ВеселковаА. Ю.VeselkovaA. Yu.

Веселкова Александра Юрьевна - врач-патологоанатом патологоанатомического отделения.

Ул. Маршала Новикова, д. 23, Москва, 123098

Alexandra Yu. Veselkova - Pathologist of the Pathology Department.

23 Marshal Novikov str., Moscow, 123098

veselkovaaa@gmail.comЛукьянчиковаА. С.Luk'yanchikovaА. S.

Лукьянчикова Анна Сергеевна - врач-ординатор Центра хирургии и трансплантологии, лаборант лаборатории новых хирургических технологий.

Ул. Маршала Новикова, д. 23, Москва, 123098

Anna S. Lukianchikova - Resident, Surgery and Transplantation Center; Laboratory Assistant, Laboratory of New Surgical Technologies.

23 Marshal Novikov str., Moscow, 123098

anlukyanchikova@yandex.ruhttps://orcid.org/0000-0001-9256-6674КучеровА. А.KucherovA. A.

Кучеров Алексей Алексеевич – кардиолог.

Петроверигский пер., 10, стр. 3, Москва, 101990

Alexey A. Kucherov – Cardiologist.

Petroverigsky Lane, 10, p. 3, Moscow, 101990

kucherovalexey@yandex.ruФедеральный медицинский биофизический центр имени А.И. БурназянаРоссияBurnasyan Federal Medical Biophysical CenterRussian FederationФедеральный медицинский биофизический центр имени А.И. Бурназяна; Научно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияBurnasyan Federal Medical Biophysical Center; N.V. Sklifosovsky Research Institute for Emergency MedicineRussian FederationНациональный медицинский исследовательский центр терапии и профилактической медициныРоссияNational Medical Research Center for Therapy and Preventive MedicineRussian Federation202314092023134134144Copyright © Восканян С.Э., Сюткин В.Е., Сушков А.И., Восканян Ю.В., Веселкова А.Ю., Лукьянчикова А.С., Кучеров А.А., 20232023Восканян С.Э., Сюткин В.Е., Сушков А.И., Восканян Ю.В., Веселкова А.Ю., Лукьянчикова А.С., Кучеров А.А.Voskanyan S.E., Syutkin V.E., Sushkov A.I., Voskanyan Y.V., Veselkova A.Y., Luk'yanchikova А.S., Kucherov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/781

В настоящее время годичная выживаемость пациентов, перенёсших трансплантацию печени, составляет 80-90 %. В отдалённые сроки после операции сохраняются повышенные, по сравнению с общей популяцией, риски летального исхода. При этом в структуре смертности реципиентов внепеченочные причины превалируют над патологией трансплантата. Злокачественные новообразования, сердечно-сосудистые заболевания, инфекции, метаболические нарушения и болезни почек - ключевые факторы, оказывающие негативное влияние на отдалённые результаты трансплантаций. В статье приводится обзор и обобщение актуальных сведений о распространённости, структуре и прогностическом значении различных вариантов внепечёночной патологии у реципиентов печени в отдалённом послеоперационном периоде.

Nowadays, the one-year survival rate of liver transplant recipients is 80-90 %. In the long term after surgery, there are increased risks of death compared with the general population. At the same time, in the structure of death of recipients, extrahepatic causes prevail over graft pathology. Cancers, cardiovascular diseases, infections, metabolic disorders, and kidney disease are key factors that negatively affect long-term outcomes of transplants. The article provides an overview and summary of current data on the prevalence, structure and prognostic value of various types’ of late post-transplant extrahepatic pathology in liver transplant recipients.

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The authors declare that there are no conflicts of interest present.