vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2023.5.CLIN.2vmireaviz-842Research ArticleКлиническая медицинаClinical medicineМультипараметрическое ультразвуковое исследование узлов щитовидной железы: определение риска злокачественности (обзор литературы)Multiparametric ultrasound in thyroid nodules evaluation: risk-stratification (review of literature)СолововВ. А.SolovovV. A.

Соловов Вячеслав Александрович - д-р мед. наук, заведующий отделением интервенционных методовдиагностики и лечения,

ул. Солнечная, д. 50, Самара, 443031

50 Solnechnaya str., Samara, 443031

samarasdc@yahoo.comАблековаО. Н.AblekovaO. N.

Аблекова Ольга Николаевна - заведующая отделением ультразвуковой диагностики,

ул. Солнечная, д. 50, Самара, 443031

50 Solnechnaya str., Samara, 443031

o.ablekova@mail.ruСамарский областной клинический онкологический диспансерРоссияSamara Regional Clinical Oncology CenterRussian Federation2023160920231355155Copyright © Соловов В.А., Аблекова О.Н., 20232023Соловов В.А., Аблекова О.Н.Solovov V.A., Ablekova O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/842

Ультразвуковое исследование (УЗИ) широко используется для диагностики заболеваний щитовидной железы. Основными достоинствами метода являются низкая стоимость, отсутствие ионизирующего облучения, высокая чувствительность и возможность проведения инвазивных вмешательств под ультразвуковой навигацией. При этом отмечаются существенные недостатки ультразвукового исследования, такие как низкая специфичность и значительная зависимость от опыта врача. Для повышения специфичности и нивелирования влияния опыта оператора в последнее десятилетие были разработаны новые методики ультразвукового исследования, такие как УЗ-эластография и УЗИ с контрастным усилением. Вместе с серо-шкальным УЗИ они являются неотъемлемой частью мультипараметрического ультразвукового исследования. В обзоре представлены актуальные литературные данные о диагностической эффективности мультипараметрического УЗИ узлов щитовидной железы, особое внимание уделено стратификации рисков злокачественных образований.

Ultrasound (US) is the first imaging modality for thyroid parenchyma evaluation. In the last decades, the role of ultrasound has been improved with the introduction of new US software, such as contrast-enhanced ultrasound and US-elastography. US-elastography is nowadays recognized as an essential part of the multiparametric ultrasound examination. More controversial is the role of contrast-enhanced ultrasound in thyroid evaluation, due to its high variability in sensitivity and specificity. We have therefore drawn up an updated representation of the current evidence in the literature for thyroid nodule multiparametric ultrasound evaluation with particular regard to US-elastography and contrast-enhanced ultrasound.

мультипараметрическое УЗИузлы щитовидной железыэластографияУЗИ с контрастным усилениемmultiparametric ultrasoundthyroid nodulesUS-elastographyCEUSReferencesCabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016 Dec 3;388(10061):2783-2795. https://doi.org/10.1016/S0140-6736(16)30172-6 Epub 2016 May 27. PMID: 27240885.1 Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016 Dec 3;388(10061):2783-2795. https://doi.org/10.1016/S0140- 6736(16)30172-6 Epub 2016 May 27. PMID: 27240885.Guth S, Theune U, Aberle J, Galach A, Bamberger CM. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur J Clin Invest. 2009 Aug;39(8):699-706. https://doi.org/10.1111/j.1365-2362.2009.02162.x PMID: 19601965.2 Guth S, Theune U, Aberle J, Galach A, Bamberger CM. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur J Clin Invest. 2009 Aug;39(8):699-706. https://doi.org/10.1111/j.1365-2362.2009.02162.x PMID: 19601965.Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L. European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS. Eur Thyroid J. 2017 Sep;6(5):225-237. https://doi.org/10.1159/000478927 Epub 2017 Aug 8. PMID: 29167761; PMCID: PMC5652895.3 Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L. European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS. Eur Thyroid J. 2017 Sep;6(5):225-237. https://doi.org/10.1159/000478927 Epub 2017 Aug 8. PMID: 29167761; PMCID: PMC5652895.Rago T, Cantisani V, Ianni F, Chiovato L, Garberoglio R, Durante C, Frasoldati A, Spiezia S, Farina R, Vallone G, Pontecorvi A, Vitti P. Thyroid ultrasonography reporting: consensus of Italian Thyroid Association (AIT), Italian Society of Endocrinology (SIE), Italian Society of Ultrasonography in Medicine and Biology (SIUMB) and Ultrasound Chapter of Italian Society of Medical Radiology (SIRM). J Endocrinol Invest. 2018 Dec;41(12):1435-1443. https://doi.org/10.1007/s40618-018-0935-8 Epub 2018 Oct 16. PMID: 30327945.4 Rago T, Cantisani V, Ianni F, Chiovato L, Garberoglio R, Durante C, Frasoldati A, Spiezia S, Farina R, Vallone G, Pontecorvi A, Vitti P. Thyroid ultrasonography reporting: consensus of Italian Thyroid Association (AIT), Italian Society of Endocrinology (SIE), Italian Society of Ultrasonography in Medicine and Biology (SIUMB) and Ultrasound Chapter of Italian Society of Medical Radiology (SIRM). J Endocrinol Invest. 2018 Dec;41(12):1435-1443. https://doi.org/10.1007/s40618-018-0935-8 Epub 2018 Oct 16. PMID: 30327945.He YP, Xu HX, Zhao CK, Sun LP, Li XL, Yue WW, Guo LH, Wang D, Ren WW, Wang Q, Qu S. Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system. Sci Rep. 2017 Jul 31;7(1):6906. https://doi.org/10.1038/s41598-017-07353-y PMID: 28761147; PMCID: PMC5537223.5 He YP, Xu HX, Zhao CK, Sun LP, Li XL, Yue WW, Guo LH, Wang D, Ren WW, Wang Q, Qu S. Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system. Sci Rep. 2017 Jul 31;7(1):6906. https://doi.org/10.1038/s41598- 017-07353-y PMID: 28761147; PMCID: PMC5537223.Pacini F, Basolo F, Bellantone R, Boni G, Cannizzaro MA, De Palma M, Durante C, Elisei R, Fadda G, Frasoldati A, Fugazzola L, Guglielmi R, Lombardi CP, Miccoli P, Papini E, Pellegriti G, Pezzullo L, Pontecorvi A, Salvatori M, Seregni E, Vitti P. Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies. J Endocrinol Invest. 2018 Jul;41(7):849-876. https://doi.org/10.1007/s40618-018-0884-2 Epub 2018 May 4. PMID: 29729004.6 Pacini F, Basolo F, Bellantone R, Boni G, Cannizzaro MA, De Palma M, Durante C, Elisei R, Fadda G, Frasoldati A, Fugazzola L, Guglielmi R, Lombardi CP, Miccoli P, Papini E, Pellegriti G, Pezzullo L, Pontecorvi A, Salvatori M, Seregni E, Vitti P. Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies. J Endocrinol Invest. 2018 Jul;41(7):849-876. https://doi.org/10.1007/s40618-018-0884-2 Epub 2018 May 4. PMID: 29729004.Radzina M, Cantisani V, Rauda M, Nielsen MB, Ewertsen C, D'Ambrosio F, Prieditis P, Sorrenti S. Update on the role of ultrasound guided radiofrequency ablation for thyroid nodule treatment. Int J Surg. 2017 May;41 Suppl 1:S82-S93. https://doi.org/10.1016/j.ijsu.2017.02.010 PMID: 28506420.7 Radzina M, Cantisani V, Rauda M, Nielsen MB, Ewertsen C, D'Ambrosio F, Prieditis P, Sorrenti S. Update on the role of ultrasound guided radiofrequency ablation for thyroid nodule treatment. Int J Surg. 2017 May;41 Suppl 1:S82-S93. https://doi.org/10.1016/j.ijsu.2017.02.010 PMID: 28506420.Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version). Ultraschall Med. 2018 Apr;39(2):e2-e44. English. https://doi.org/10.1055/a-0586-1107 PMID: 29510439.8 Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version). Ultraschall Med. 2018 Apr;39(2):e2-e44. English. https://doi.org/10.1055/a-0586-1107 PMID: 29510439.Tessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Teefey SA, et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. J Am Coll Radiol. 2017 May;14(5):587-595. https://doi.org/10.1016/j.jacr.2017.01.046 Epub 2017 Apr 2. PMID: 28372962.9 Tessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Teefey SA, et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. J Am Coll Radiol. 2017 May;14(5):587-595. https://doi.org/10.1016/j.jacr.2017.01.046 Epub 2017 Apr 2. PMID: 28372962.Cantisani V, David E, Grazhdani H, Rubini A, Radzina M, Dietrich CF et al. Prospective Evaluation of Semiquantitative Strain Ratio and Quantitative 2D Ultrasound Shear Wave Elastography (SWE) in Association with TIRADS Classification for Thyroid Nodule Characterization. Ultraschall Med. 2019 Aug;40(4):495-503. English. https://doi.org/10.1055/a-0853-1821 Epub 2019 May 28. PMID: 31137050.10 Cantisani V, David E, Grazhdani H, Rubini A, Radzina M, Dietrich CF et al. Prospective Evaluation of Semiquantitative Strain Ratio and Quantitative 2D Ultrasound Shear Wave Elastography (SWE) in Association with TIRADS Classification for Thyroid Nodule Characterization. Ultraschall Med. 2019 Aug;40(4):495-503. English. https://doi.org/10.1055/a-0853-1821 Epub 2019 May 28. PMID: 31137050.Ramundo V, Di Gioia CRT, Falcone R, Lamartina L, Biffoni M, Giacomelli L et al. Diagnostic Performance of Neck Ultrasonography in the Preoperative Evaluation for Extrathyroidal Extension of Suspicious Thyroid Nodules. World J Surg. 2020 Aug;44(8):2669-2674. https://doi.org/10.1007/s00268-020-05482-6 PMID: 32193621.11 Ramundo V, Di Gioia CRT, Falcone R, Lamartina L, Biffoni M, Giacomelli L et al. Diagnostic Performance of Neck Ultrasonography in the Preoperative Evaluation for Extrathyroidal Extension of Suspicious Thyroid Nodules. World J Surg. 2020 Aug;44(8):2669-2674. https://doi.org/10.1007/s00268-020-05482-6 PMID: 32193621.Papini E, Pacella CM, Solbiati LA, Achille G, Barbaro D, Bernardi S et al. Minimally-invasive treatments for benign thyroid nodules: A Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group. Int. J. Hyperth. 2019,36,375-381. https://doi.org/10.1159/00050848412 Papini E, Pacella CM, Solbiati LA, Achille G, Barbaro D, Bernardi S et al. Minimally-invasive treatments for benign thyroid nodules: A Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group. Int. J. Hyperth. 2019,36,375-381. https://doi.org/10.1159/000508484Trimboli P, Durante C. Ultrasound risk stratification systems for thyroid nodule: between lights and shadows, we are moving towards a new era. Endocrine. 2020 Jul;69(1):1-4. https://doi.org/10.1007/s12020-020-02196-6 Epub 2020 Jan 13. PMID: 31933234.13 Trimboli P, Durante C. Ultrasound risk stratification systems for thyroid nodule: between lights and shadows, we are moving towards a new era. Endocrine. 2020 Jul;69(1):1-4. https://doi.org/10.1007/s12020-020-02196-6 Epub 2020 Jan 13. PMID: 31933234.Castellana M, Grani G, Radzina M, Guerra V, Giovanella L, Deandrea M, Ngu R, Durante C, Trimboli P. Performance of EU-TIRADS in malignancy risk stratification of thyroid nodules: a meta-analysis. Eur J Endocrinol. 2020 Sep;183(3):255-264. https://doi.org/10.1530/EJE-20-0204 PMID: 32544875.14 Castellana M, Grani G, Radzina M, Guerra V, Giovanella L, Deandrea M, Ngu R, Durante C, Trimboli P. Performance of EU-TIRADS in malignancy risk stratification of thyroid nodules: a meta-analysis. Eur J Endocrinol. 2020 Sep;183(3):255-264. https://doi.org/10.1530/EJE-20-0204 PMID: 32544875.Поморцев А.В., Токаренко О.С. Диагностическая значимость мультипараметрического ультразвукового исследования и системы EU-TIRADS в дифференциальной диагностике очаговых образований щитовидной железы. Инновационная медицина Кубани. 2020;(3):29-37. https:/doi.org/10.35401/2500-0268-2020-19-3-29-37.15 Pomortsev A.V., Tokarenko O.S. Diagnostic value of multiparametric ultrasound and the EUTIRADS system for differentiation of focal thyroid lesions. Innovative Medicine of Kuban. 2020;(3):29-37. (In Russ) https://doi.org/10.35401/2500-0268- 2020-19-3-29-37.Bardet S, Ciappuccini R, Pellot-Barakat C, Monpeyssen H, Michels JJ, Tissier F et al. Shear Wave Elastography in Thyroid Nodules with Indeterminate Cytology: Results of a Prospective Bicentric Study. Thyroid. 2017 Nov;27(11):1441-1449. https://doi.org/10.1089/thy.2017.0293 PMID: 28982296.16 Bardet S, Ciappuccini R, Pellot-Barakat C, Monpeyssen H, Michels JJ, Tissier F et al. Shear Wave Elastography in Thyroid Nodules with Indeterminate Cytology: Results of a Prospective Bicentric Study. Thyroid. 2017 Nov;27(11):1441-1449. https://doi.org/10.1089/thy.2017.0293 PMID: 28982296.Grani G, Lamartina L, Ascoli V, Bosco D, Biffoni M, Giacomelli L et al. Reducing the Number of Unnecessary Thyroid Biopsies While Improving Diagnostic Accuracy: Toward the "Right" TIRADS. J Clin Endocrinol Metab. 2019 Jan 1;104(1):95-102. https://doi.org/10.1210/jc.2018-01674 PMID: 30299457.17 Grani G, Lamartina L, Ascoli V, Bosco D, Biffoni M, Giacomelli L et al. Reducing the Number of Unnecessary Thyroid Biopsies While Improving Diagnostic Accuracy: Toward the "Right" TIRADS. J Clin Endocrinol Metab. 2019 Jan 1;104(1):95-102. https://doi.org/10.1210/jc.2018-01674 PMID: 30299457.Li W, Wang Y, Wen J, Zhang L, Sun Y. Diagnostic Performance of American College of Radiology TI-RADS: A Systematic Review and Meta-Analysis. AJR Am J Roentgenol. 2021 Jan;216(1):38-47. https://doi.org/10.2214/AJR.19.22691 Epub 2020 Nov 19. PMID: 32603229.18 Li W, Wang Y, Wen J, Zhang L, Sun Y. Diagnostic Performance of American College of Radiology TI-RADS: A Systematic Review and Meta-Analysis. AJR Am J Roentgenol. 2021 Jan;216(1):38-47. https://doi.org/10.2214/AJR.19.22691 Epub 2020 Nov 19. PMID: 32603229.Wei X, Li Y, Zhang S, Gao M. Meta-analysis of thyroid imaging reporting and data system in the ultrasonographic diagnosis of 10,437 thyroid nodules. Head Neck. 2016 Feb;38(2):309-15. https://doi.org/10.1002/hed.23878 Epub 2015 Jun 16. PMID: 25244250.19 Wei X, Li Y, Zhang S, Gao M. Meta-analysis of thyroid imaging reporting and data system in the ultrasonographic diagnosis of 10,437 thyroid nodules. Head Neck. 2016 Feb;38(2):309-15. https://doi.org/10.1002/hed.23878 Epub 2015 Jun 16. PMID: 25244250.Yoon JH, Lee HS, Kim EK, Moon HJ, Kwak JY. Malignancy Risk Stratification of Thyroid Nodules: Comparison between the Thyroid Imaging Reporting and Data System and the 2014 American Thyroid Association Management Guidelines. Radiology. 2016 Mar;278(3):917-24. https://doi.org/10.1148/radiol.2015150056 Epub 2015 Sep 8. PMID: 26348102.20 Yoon JH, Lee HS, Kim EK, Moon HJ, Kwak JY. Malignancy Risk Stratification of Thyroid Nodules: Comparison between the Thyroid Imaging Reporting and Data System and the 2014 American Thyroid Association Management Guidelines. Radiology. 2016 Mar;278(3):917-24. https://doi.org/10.1148/radiol.2015150056 Epub 2015 Sep 8. PMID: 26348102.Александров Ю.К., Яновская Е.А., Шубин Л.Б., Дякив А.Д. Эффективность стратификационных систем в диагностике узловых заболеваний щитовидной железы. Проблемы эндокринологии. 2019;65(4):216-226. https://doi.org/10.14341/probl10087.21 Aleksandrov Yu.K., Yanovskaya E.A., Shubin L.B., Dyakiv A.D. The effectiveness of risk stratification systems in diagnosis of nodular thyroid disorders. Problems of Endocrinology. 2019;65(4):216-226. https://doi.org/10.14341/probl10087.Cantisani V, Catania A, De Antoni E, Greco R, Caruso R, Di Segni M et al. Is pattern III as evidenced by US color-Doppler useful in predicting thyroid nodule malignancy? Large-scale retrospective analysis. Clin Ter. 2010;161(2):e49-52. PMID: 20499019.22 Cantisani V, Catania A, De Antoni E, Greco R, Caruso R, Di Segni M et al. Is pattern III as evidenced by US color-Doppler useful in predicting thyroid nodule malignancy? Large-scale retrospective analysis. Clin Ter. 2010;161(2):e49-52. PMID: 20499019.Dighe M, Barr R, Bojunga J, Cantisani V, Chammas MC, Cosgrove D et al. Thyroid Ultrasound: State of the Art. Part 2 - Focal Thyroid Lesions. Med Ultrason. 2017 Apr 22;19(2):195-210. https://doi.org/10.11152/mu-999 PMID: 28440355.23 Dighe M, Barr R, Bojunga J, Cantisani V, Chammas MC, Cosgrove D et al. Thyroid Ultrasound: State of the Art. Part 2 - Focal Thyroid Lesions. Med Ultrason. 2017 Apr 22;19(2):195-210. https://doi.org/10.11152/mu-999 PMID: 28440355.Moss WJ, Finegersh A, Pang J, Califano JA, Coffey CS, Orosco RK, Brumund KT. Needle Biopsy of Routine Thyroid Nodules Should Be Performed Using a Capillary Action Technique with 24- to 27-Gauge Needles: A Systematic Review and Meta-Analysis. Thyroid. 2018 Jul;28(7):857-863. https://doi.org/10.1089/thy.2017.0643 Epub 2018 Jun 5. PMID: 29742978.24 Moss WJ, Finegersh A, Pang J, Califano JA, Coffey CS, Orosco RK, Brumund KT. Needle Biopsy of Routine Thyroid Nodules Should Be Performed Using a Capillary Action Technique with 24- to 27-Gauge Needles: A Systematic Review and Meta-Analysis. Thyroid. 2018 Jul;28(7):857-863. https://doi.org/10.1089/thy.2017.0643 Epub 2018 Jun 5. PMID: 29742978.Feldkamp J, Führer D, Luster M, Musholt TJ, Spitzweg C, Schott M. Fine Needle Aspiration in the Investigation of Thyroid Nodules. Dtsch Arztebl Int. 2016 May 20;113(20):353-9. https://doi.org/10.3238/arztebl.2016.0353 PMID: 27294815; PMCID: PMC4906830.25 Feldkamp J, Führer D, Luster M, Musholt TJ, Spitzweg C, Schott M. Fine Needle Aspiration in the Investigation of Thyroid Nodules. Dtsch Arztebl Int. 2016 May 20;113(20):353-9. https://doi.org/10.3238/arztebl.2016.0353 PMID: 27294815; PMCID: PMC4906830.Тимофеева Л.А., Сенча А.Н., Тухбатуллин М.Г., Шубин Л.Б. Современные аспекты ультразвуковой эластографии в дифференциальной диагностике узловых новообразований щитовидной железы. Российский электронный журнал лучевой диагностики. 2019;9(3):30-40. https://doi.org/10.21569/2222-7415-2019-9-3-30-40.26 Timofeeva L.A., Sencha A.N., Tukhbatullin M.G., Shubin L.B. Modern aspects of ultrasound elastography in differential diagnosis of nodular thyroid neoplasms. REJR. 2019;9(3):30-40. https://doi.org/10.21569/2222-7415-2019-9-3-30-40.Sorrenti S, Dolcetti V, Fresilli D, Del Gaudio G, Pacini P, Huang P et al. The Role of CEUS in the Evaluation of Thyroid Cancer: From Diagnosis to Local Staging. J Clin Med. 2021 Sep 30;10(19):4559. https://doi.org/10.3390/jcm10194559 PMID: 34640574; PMCID: PMC8509399.27 Sorrenti S, Dolcetti V, Fresilli D, Del Gaudio G, Pacini P, Huang P et al. The Role of CEUS in the Evaluation of Thyroid Cancer: From Diagnosis to Local Staging. J Clin Med. 2021 Sep 30;10(19):4559. https://doi.org/10.3390/jcm10194559 PMID: 34640574; PMCID: PMC8509399.Celletti I, Fresilli D, De Vito C, Bononi M, Cardaccio S, Cozzolino A et al. TIRADS, SRE and SWE in INDETERMINATE thyroid nodule characterization: Which has better diagnostic performance? Radiol Med. 2021 Sep;126(9):1189-1200. https://doi.org/10.1007/s11547-021-01349-5 PMID: 34129178; PMCID: PMC8370962.28 Celletti I, Fresilli D, De Vito C, Bononi M, Cardaccio S, Cozzolino A et al. TIRADS, SRE and SWE in INDETERMINATE thyroid nodule characterization: Which has better diagnostic performance? Radiol Med. 2021 Sep;126(9):1189-1200. https://doi.org/10.1007/s11547-021-01349-5 PMID: 34129178; PMCID: PMC8370962.Samir AE, Dhyani M, Anvari A, Prescott J, Halpern EF, Faquin WC, Stephen A. Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular-patterned Lesions of the Thyroid: Diagnostic Accuracy and Optimal Measurement Plane. Radiology. 2015 Nov;277(2):565-73. https://doi.org/10.1148/radiol.2015141627 PMID: 25955578.29 Samir AE, Dhyani M, Anvari A, Prescott J, Halpern EF, Faquin WC, Stephen A. Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular-patterned Lesions of the Thyroid: Diagnostic Accuracy and Optimal Measurement Plane. Radiology. 2015 Nov;277(2):565-73. https://doi.org/10.1148/radiol.2015141627 PMID: 25955578.Chang N, Zhang X, Wan W, Zhang C, Zhang X. The Preciseness in Diagnosing Thyroid Malignant Nodules Using Shear-Wave Elastography. Med Sci Monit. 2018 Feb 2;24:671-677. https://doi.org/10.12659/msm.904703 PMID: 29391387; PMCID: PMC5806774.30 Chang N, Zhang X, Wan W, Zhang C, Zhang X. The Preciseness in Diagnosing Thyroid Malignant Nodules Using Shear-Wave Elastography. Med Sci Monit. 2018 Feb 2;24:671-677. https://doi.org/10.12659/msm.904703 PMID: 29391387; PMCID: PMC5806774.Filho RHC, Pereira FL, Iared W. Diagnostic Accuracy Evaluation of Two-Dimensional Shear Wave Elastography in the Differentiation Between Benign and Malignant Thyroid Nodules: Systematic Review and Meta-analysis. J Ultrasound Med. 2020 Sep;39(9):1729-1741. https://doi.org/10.1002/jum.15271 PMID: 32227500.31 Filho RHC, Pereira FL, Iared W. Diagnostic Accuracy Evaluation of Two-Dimensional Shear Wave Elastography in the Differentiation Between Benign and Malignant Thyroid Nodules: Systematic Review and Meta-analysis. J Ultrasound Med. 2020 Sep;39(9):1729-1741. https://doi.org/10.1002/jum.15271 PMID: 32227500.Hu X, Liu Y, Qian L. Diagnostic potential of real-time elastography (RTE) and shear wave elastography (SWE) to differentiate benign and malignant thyroid nodules: A systematic review and meta-analysis. Medicine (Baltimore). 2017 Oct;96(43):e8282. https://doi.org/10.1097/MD.0000000000008282 PMID: 29068996; PMCID: PMC5671829.32 Hu X, Liu Y, Qian L. Diagnostic potential of real-time elastography (RTE) and shear wave elastography (SWE) to differentiate benign and malignant thyroid nodules: A systematic review and meta-analysis. Medicine (Baltimore). 2017 Oct;96(43):e8282. https://doi.org/10.1097/MD.0000000000008282 PMID: 29068996; PMCID: PMC5671829.Trimboli P, Castellana M, Virili C, Havre RF, Bini F, Marinozzi F et al. Performance of contrast-enhanced ultrasound (CEUS) in assessing thyroid nodules: a systematic review and meta-analysis using histological standard of reference. Radiol Med. 2020 Apr;125(4):406-415. https://doi.org/10.1007/s11547-019-01129-2 PMID: 31970579.33 Trimboli P, Castellana M, Virili C, Havre RF, Bini F, Marinozzi F et al. Performance of contrast-enhanced ultrasound (CEUS) in assessing thyroid nodules: a systematic review and meta-analysis using histological standard of reference. Radiol Med. 2020 Apr;125(4):406-415. https://doi.org/10.1007/s11547-019-01129-2 PMID: 31970579.Liu Q, Cheng J, Li J, Gao X, Li H. The diagnostic accuracy of contrast-enhanced ultrasound for the differentiation of benign and malignant thyroid nodules: A PRISMA compliant meta-analysis. Medicine (Baltimore). 2018 Dec;97(49):e13325. https://doi.org/10.1097/MD.0000000000013325 PMID: 30544392; PMCID: PMC6310493.34 Liu Q, Cheng J, Li J, Gao X, Li H. The diagnostic accuracy of contrast-enhanced ultrasound for the differentiation of benign and malignant thyroid nodules: A PRISMA compliant meta-analysis. Medicine (Baltimore). 2018 Dec;97(49):e13325. https://doi.org/10.1097/MD.0000000000013325 PMID: 30544392; PMCID: PMC6310493.Тимофеева Л.А., Шубин Л.Б. Обоснование применения соноэластографии при узловой патологии щитовидной железы. Вестник рентгенологии и радиологии. 2019;100(5):242-246. https://doi.org/10.20862/0042-4676-2019-100-5-242-246.35 Timofeeva L.A., Shubin L.B. A Rationale for Using Sonoelastography in Thyroid Nodular Pathology. Journal of radiology and nuclear medicine. 2019;100(5):242-246. (In Russ) https://doi.org/10.20862/0042-4676-2019-100-5-242-246.Zhang J, Zhang X, Meng Y, Chen Y. Contrast-enhanced ultrasound for the differential diagnosis of thyroid nodules: An updated meta-analysis with comprehensive heterogeneity analysis. PLoS One. 2020 Apr 20;15(4):e0231775. https://doi.org/10.1371/journal.pone.0231775 PMID: 32310968; PMCID: PMC7170259.36 Zhang J, Zhang X, Meng Y, Chen Y. Contrast-enhanced ultrasound for the differential diagnosis of thyroid nodules: An updated meta-analysis with comprehensive heterogeneity analysis. PLoS One. 2020 Apr 20;15(4):e0231775. https://doi.org/10.1371/journal.pone.0231775 PMID: 32310968; PMCID: PMC7170259.Zhao CK, Xu HX. Ultrasound elastography of the thyroid: principles and current status. Ultrasonography. 2019 Apr;38(2):106-124. https://doi.org/10.14366/usg.18037 PMID: 30690960; PMCID: PMC6443591.37 Zhao CK, Xu HX. Ultrasound elastography of the thyroid: principles and current status. Ultrasonography. 2019 Apr;38(2):106-124. https://doi.org/10.14366/usg.18037 PMID: 30690960; PMCID: PMC6443591.

The authors declare that there are no conflicts of interest present.