vmireavizВестник медицинского института «РЕАВИЗ». Реабилитация, Врач и ЗдоровьеBulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)2226-762X2782-1579РЕАВИЗ10.20340/vmi-rvz.2020.4.11vmireaviz-87Research ArticleКлиническая медицинаClinical medicineПрофилирование аполипопротеинов как вариант персонифицированного подхода к диа-гностике и коррекции дислипидемийErsonified diagnostic and correction dyslipidemia approach by profiling of apolipoproteinsКачковскийМ. А.KachkovskyM. A.

Качковский Михаил Аркадьевич - доктор медицинских наук, профессор, директор НИИ атеросклероза и дислипидемий, врач-кардиолог, терапевт, гастроэнтеролог

Самара

Samara

ВведенскаяИ. П.VvedenskayaI. P.

Введенская Ирина Петровна - кандидат медицинских наук, ассистент

Самара

Samara

ВведенскийВ. Ю.VvedenskyV. Yu.

Введенский Василий Юрьевич - член Самарской областной ассоциации врачей, врач функциональной диагностики

Самара

Samara

СупильниковА. А.SupilnikovA. A.

Супильников Алексей Александрович - кандидат медицинских наук, доцент, первый проректор по научной деятельности, заведующий кафедрой морфологии и патологии

Самара

Samara

ПономареваЮ. В.PonomarevaJ. V.

Пономарева Юлия Вячеславовна - доктор медицинских наук, член Российского общества хирургов, Член всероссийского общества регенеративной медицины, директор

Самара

Samara

МиляковаМ. Н.MilyakovaM. N.

Милякова Марина Николаевна - кандидат биологических наук, доцент кафедры морфологии и патологии

Самара

Samara

Частное учреждение образовательная организация высшего образования «Медицинский университет «Реавиз»РоссияPrivate institution educational organization of higher education "Medical University ReaviesRussian FederationФГБОУ ВО «Самарский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Institution of Higher Education «Samara State Medical University» Ministry of Health of the Russian FederationRussian FederationГБУЗ Самарской области «Отрадненская городская больница»РоссияState Budgetary Institution of Samara Region Otradnenskaya Municipal HospitalRussian FederationООО «АРТБИО»РоссияARTBIO LLCRussian Federation2020311220200488104Copyright © Качковский М.А., Введенская И.П., Введенский В.Ю., Супильников А.А., Пономарева Ю.В., Милякова М.Н., 20202020Качковский М.А., Введенская И.П., Введенский В.Ю., Супильников А.А., Пономарева Ю.В., Милякова М.Н.Kachkovsky M.A., Vvedenskaya I.P., Vvedensky V.Y., Supilnikov A.A., Ponomareva J.V., Milyakova M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik.reaviz.ru/jour/article/view/87

В диагностике, методах профилактики и лечении дислипидемий остается множество нерешенных вопросов, несмотря на логичные концепции имеющихся клинических рекомендаций. Среди таких развитие сердечно-сосудистых заболеваний, при достижении и поддержании целевых значений липидного обмена. Это возможно объяснить необходимостью смены парадигмы существующих подходов. С этих позиций аполипопротеины как белковые составляющие липопротеинов могут значительно точнее охарактеризовать дислипидемический статус пациента, поскольку их структура и состав являются уникальными. На основании аполипопрофилирования возможен выбор персонифицированной стратегии профилактики и лечения дислипидемий. В настоящее время появились новые данные о функциях апобелков, их генетических полиморфизмах, предложены молекулярные препараты для коррекции их содержания и липидного обмена в целом.

Many questions remain in the diagnosis, treatment, and prevention of dyslipidemia, despite the available clinical recommendations. Among these issues is the cause of cardiovascular diseases, when achieving and maintaining the target values of lipid metabolism. We need to change the existing paradigm. Apolipoproteins as protein components of lipoproteins can significantly more accurately characterize the dyslipidemic status of a patient, since their structure and composition are unique. A personalized strategy for the prevention and treatment of dyslipidemia is possible based on the apolipoprotein profile. At present, new data on the functions of apolipoproteins, their genetic polymorphisms, and molecular preparations for correcting their content and lipid metabolism have been proposed.

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The authors declare that there are no conflicts of interest present.