Influence of interferon types on COVID-19 prevention and treatment
https://doi.org/10.20340/vmi-rvz.2021.5.COVID.3
Abstract
This article discusses the properties of endogenous and exogenous interferon as the most effective element in the fight against a new coronavirus infection, analyzes the use of various groups of interferons, the time criteria for their use, and resistance to modified strains of coronavirus.
About the Authors
S. S. Saidov
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Moscow
Competing Interests:
The authors declare no competing interests
S. N. Ionov
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Moscow
Competing Interests:
The authors declare no competing interests
A. S. Saidov
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Moscow
Competing Interests:
The authors declare no competing interests
L. V. Krasovskaya
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Moscow
Competing Interests:
The authors declare no competing interests
A. V. Zabotnov
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Moscow
Competing Interests:
The authors declare no competing interests
References
1. Shokri S, Mahmoudvand S, Taherkhani R, Farshadpour F. Modulation of the immune response by Middle East respiratory syndrome coronavirus. J. Cell. Physiol. 2019;234(3):2143-51. https://doi.org/10.1002/jcp.27155
2. Narovlyanskiy A.N. Classification and mechanisms of interferon Actions. In: Ershov F.I., ed. Jubilee Collection «Interferon – 50 Years» [Yubileynyy sbornik «Interferonu – 50 let»]. Moscow. 2007:44-50. (in Russ).
3. Busnadiego I, Fernbach S, Pohl MO, Karakus U, Huber M, Trkola A et al. Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2. mBio. 2020,Sep.10;11(5): e01928-20. https://doi.org/10.1128/mBio.01928-20 PMID: 32913009; PMCID: PMC7484541. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32913009/
4. Vanderheiden A, Ralfs P, Chirkova T et al. Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures. J Virol. 2020,Sep.15;94(19): e00985-20. https://doi.org/10.1128/JVI.00985-20 PMID: 32699094; PMCID: PMC7495371. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32699094/
5. Zhongji Meng, Tongyu Wang, Li Chen et al. An experimental trial of recombinant human interferon alpha nasal drops to prevent COVID-19 in medical staff in an epidemic area. https://doi.org/10.1101/2020.04.11.20061473
6. Felgenhauer U, Schoen A, Gad HH et al. Inhibition of SARS-CoV-2 by type I and type III interferons. J Biol Chem. 2020,Oct.9;295(41):13958-13964. https://doi.org/10.1074/jbc.AC120.013788. Epub 2020 Jun 25. PMID: 32587093; PMCID: PMC7549028. https://pubmed.ncbi.nlm.nih.gov/32587093/
7. Pereda R, Gonzбlez D, Rivero HB et al. Therapeutic Effectiveness of Interferon-α2b Against COVID-19: The Cuban Experience. J Interferon Cytokine Res. 2020, Sep;40(9):438-442. https://doi.org/10.1089/jir.2020.0124. PMID: 32960147. https://www.liebertpub.com/doi/10.1089/jir.2020.0124?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
8. Mordyk A.V., Ivanova O.G., Samsonov K.Yu. et al. Interferon alpha-2b in comprehensive treatment of patients with COVID-19. Infekc. bolezni (Infectious diseases). 2021;19(1):16-25. (In Russ). https://doi.org/10.20953/1729-9225-2021-1-16-25
9. Wang N, Zhan Y, Zhu L et al. Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients. Cell Host Microbe. 2020, Sep. 9;28(3):455-464.e2. https://doi.org/10.1016/j.chom.2020.07.005 Epub 2020 Jul 18. PMID: 32707096; PMCID: PMC7368656. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32707096/
10. Guo K, Barrett BS, Mickens KL, Hasenkrug KJ, Santiago ML. Interferon Resistance of Emerging SARS-CoV-2 Variants. bioRxiv [Preprint]. 2021, Mar.21:2021.03.20.436257. https://doi.org/10.1101/2021.03.20.436257 PMID: 33758840; PMCID: PMC7986999. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33758840/
Review
For citations:
Saidov S.S., Ionov S.N., Saidov A.S., Krasovskaya L.V., Zabotnov A.V. Influence of interferon types on COVID-19 prevention and treatment. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2021;11(5):17-22. (In Russ.) https://doi.org/10.20340/vmi-rvz.2021.5.COVID.3
Views:
846
Email this article 