PRODUCTION AND BIOCOMPATIBILITY EVALUATION OF A THREE-DIMENSIONAL BIOACTIVE MATRIX WITH SPECIFIED PROPERTIES BASED ON DECELLULARIZED HETEROLOGOUS BONE TISSUE
Abstract
The development of new implantable materials for bone regeneration remains a challenging task that is currently being considered from the perspective of tissue engineering. Such products should consist of bioactive threedimensional matrix containing either cells or biologically active proteins, including growth factors, signaling molecules, or specific genes and/or their products. The paper presents a fragment of results obtained within studies on technology of creation and ways to achieve significant qualitative and quantitative parameters of such a matrix and studies evaluating biocompatibility in vivo using the original model of a critical bone defect.
About the Authors
Yu. V. Ponomareva
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
M. N. Milyakova
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
N. N. Sarbaeva
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
A. E. Atrashkova
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
A. A. Supilnikov
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
V. A. Vankov
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
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Review
For citations:
Ponomareva Yu.V., Milyakova M.N., Sarbaeva N.N., Atrashkova A.E., Supilnikov A.A., Vankov V.A. PRODUCTION AND BIOCOMPATIBILITY EVALUATION OF A THREE-DIMENSIONAL BIOACTIVE MATRIX WITH SPECIFIED PROPERTIES BASED ON DECELLULARIZED HETEROLOGOUS BONE TISSUE. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(3):5-14. (In Russ.)
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