Study of education and memory of descendants in the quality of additional loading of aqueous plant extracts
https://doi.org/10.20340/vmi-rvz.2022.6.PHYS.1
Abstract
As the body ages, free radical processes intensify and the risk of various age-related diseases increases, including memory impairment, as exchange processes in nerve cells deteriorate. The internal antioxidant system, capable of neutralizing free radicals, is not always able to cope with the growing load, and then the supply of antioxidants from outside is necessary. A source of biologically active substances possessing antioxidant activity are plant extracts possessing a pronounced therapeutic effect combined with a minimum of side effects. The purpose of our study was to study the learning and memory of the offspring of rats that received aqueous plant extracts as an additional load. The study of the learning and memory of the offspring of rats that received aqueous plant extracts of Ginkgo biloba, Centella asiatica, Eleutherococcus and a mixture of aqueous extracts of Ginkgo biloba and Centella asiatica was performed on 4-month-old animals, obtained in an experiment from 15 males and 50 females, which in the course of 30 days water extracts were obtained in a dose of 30 mg/100 g of body weight in a volume of 1 ml. The study was carried out with the help of the test "Passive escape with negative (painful) reinforcement". Conclusions: the offspring of rats that received as an additional load intragastric mixture of aqueous extracts of Ginkgo biloba and Centella asiatica are characterized by the best indicators of learning and memory, compared to the offspring of animals of the control group, and rats that received aqueous extracts of Ginkgo biloba, Centella asiatica and Eleutherococcus separately.
About the Authors
О. N. PavlovaRussian Federation
Pavlova Olga Nikolaevna, Doctor of Biological Sciences, Docent, Head of the Department of Physiology with a Course in Life Safety and Disaster Medicine
Samara
Competing Interests:
Author O.N. Pavlova is the head of the editorial office of the magazine. She did not participate in the review of this work.
O. N. Gulenko
Russian Federation
Gulenko Olga Nikolaevna, Candidate of Biological Sciences, Docent, Associate Professor of the Department of Physiology with a Course in Life Safety and Disaster Medicine
Samara
V. V. Maslyakov
Russian Federation
Maslyakov Vladimir Vladimirovich, Doctor of Medical Sciences, Professor, Professor of the Department of Mobilization Training of Public Health and Disaster Medicine
Saratov
E. S. Kanaeva
Russian Federation
Kanaeva Elena Sergeevna, Candidate of Agricultural Sciences, Associate Professor, Department of Animal Science
Samara
M. L. Temkin
Russian Federation
Temkin Mikhail Leonidovich, Postgraduate Student, Department of Morphology and Pathology
Samara
A. Yu. Kirillov
Russian Federation
Kirillov Alexander Yurievich, Head of the Zhigulevsk Department
Zhigulevsk, Samara Region
References
1. Gorshunova N.K., Rakhmanova O.V. Oxidative stress and its variations in the pathogenesis of arterial hypertension. Contemporary problems of science and education. 2018;3. URL: https://science-education.ru/ru/article/view?id=27701 (access date: 19.12.2022) (In Russ).
2. Kalinchenko S.Yu., Vorslov L.O., Tyuzikov I.A. and others Oxidative stress as a cause of systemic aging. The role of α-lipoic acid preparations (espa-lipon) in the treatment and prevention of age-associated diseases. Pharmacy. 2014;6:44–56. (In Russ).
3. Titova T., Kudryashova L., Bolgova I., Pavlova I. Oxidative stress and aging: opportunities for correction. Doctor. 2015;6:6-10. (In Russ).
4. Yarygina E.G., Prokopyeva V.D., Bokhan N.A. Oxidative stress and its correction with carnosine. The success of modern natural science. 2015;4:106–113. URL: https://natural-sciences.ru/ru/article/view?id=35076 (access date: 19.12.2022). (In Russ).
5. Kamchatnov P.R. Possible applications of ginkgo biloba extracts in neurological practice. Journal of Neurology and Psychiatry. C.C. Korsakova. 2010;110(5):51–56. (In Russ).
6. Kuznetsov K.V., Gorshkov G.I. Eleutherococcus koluchiy (Eleutherococcus senticosus) – adaptogen, stimulator of animal organism functions and immunomodulator. International journal of applied and fundamental studies. 2016;11-3:477–485. (In Russ).
7. Patent RU 2570733 c2. Combination of proanthocyanidins, such as pycnogenol or grape seeds, and Asian centella for the treatment of cardiovascular disorders, such as atherosclerosis / Belcaro Gianni, Burki Karolina, Ferrari Victor. Patent Office: Russia. 2015 (In Russ).
8. Umryukhin A.E., Chekmareva N.Yu., Sotnikov S.V., Vetrile L.A., Zakharova I.A. Behavior of rats in the "Conditional reflex passive escape" test after stressor loading on the background of immunization with conjugated glutamate with BSA. I.P. Pavlov Russian Medical and Biological Herald. 2013;2:43–48. (In Russ).
Review
For citations:
Pavlova О.N., Gulenko O.N., Maslyakov V.V., Kanaeva E.S., Temkin M.L., Kirillov A.Yu. Study of education and memory of descendants in the quality of additional loading of aqueous plant extracts. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2022;12(6):30-35. https://doi.org/10.20340/vmi-rvz.2022.6.PHYS.1