Mathematical modeling of the kinetics of multiple ethanol intake
https://doi.org/10.20340/vmi-rvz.2023.1.ICTM.2
Abstract
The aim of the study is to construct a mathematical model of the kinetics of multiple ethanol intake based on the kinetic equation of zero-order ethanol elimination with absorption and irrevocable first-order absorption deficiency, as well as its implementation in the format of a computer program. Analytical mathematical modeling of the kinetics of multiple oral administration of ethanol is performed on the basis of this kinetic equation. In the course of modeling, a kinetic summation method was developed that allows to perform a mathematical description of the dynamics of ethanol content in the body in the case of repeated intake of alcoholic beverages of any volume and strength, separated by time intervals of any duration. The developed computational algorithm is implemented in the format of the Alcohol Calculator V 3.0 computer program. The conclusion is made about the expediency of using the developed information and computing technology in the forensic assessment of the quantitative alcohol content in the body at a legally relevant time.
About the Author
G. V. NedugovRussian Federation
German V. Nedugov, PhD, Assistant Professor of the Department of Forensic Medicine,
Samara
Competing Interests:
The author declare no competing interests.
References
1. Jones AW. Impact of Trauma, Massive Blood Loss and Administration of Resuscitation Fluids on a Person's Blood-Alcohol Concentration and Rate of Ethanol Metabolism. Acad Forensic Pathol. 2016;6(1):77-88. doi: 10.23907/2016.007
2. Himemiya-Hakucho A, Fujimiya T. Pharmacokinetic analyses using absorption kinetics in low-alcohol dose cases of drunken driving. Leg Med (Tokyo). 2017;26:98-101. doi: 10.1016/j.legalmed.2017.05.002
3. Reiter GS, Boeckle M, Reiter C, Seltenhammer MH. The impact of total body water on breath alcohol calculations. Wien Klin Wochenschr. 2020;132(17-18):535-541. doi: 10.1007/s00508-020-01663-4
4. Nedugov GV. Mathematical modeling of the kinetics of a single intake of ethanol. Bulletin of the Medical Institute “REAVIZ”. Rehabilitation, Doctor and Health. 2022;12(6):148–156. (In Russian). doi: 10.20340/vmi-rvz.2022.6.ICTM.1
5. Nedugov G.V., Nedugov V.G. Mathematical modeling of the kinetics of repeated ethanol intake. Bulletin of Forensic Medicine. 2020;9(2):10-16. (In Russian).
6. Posey D, Mozayani A. The estimation of blood alcohol concentration: Widmark revisited. Forensic Sci Med Pathol. 2007;3(1):33-9. doi: 10.1385/FSMP:3:1:33
7. Searle J. Alcohol calculations and their uncertainty. Med Sci Law. 2015;55(1):58-64. doi: 10.1177/0025802414524385
Supplementary files
Review
For citations:
Nedugov G.V. Mathematical modeling of the kinetics of multiple ethanol intake. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2023;13(1):153-160. (In Russ.) https://doi.org/10.20340/vmi-rvz.2023.1.ICTM.2