Efficacy of using platelet rich plasma lysate in treatment patients with proximal humerus fracture

Relevance. Proximal humerus fractures account for up to 75 % of all humerus fractures in patients over 60 years of age. The number of such patients is constantly growing, but there is no consensus on the treatment of this injury.

Target. To determine the effectiveness of using platelet-rich lysate in patients with proximal humerus fractures.

Object and methods. A randomized prospective study was conducted. All operated patients (n = 34) were divided into 3 groups. The first group (main 1) included patients who were administered platelet-rich plasma lysate at the end of surgery – 13 patients. The second (main 2) included patients who used platelet-rich plasma on the 14^th day from the moment of surgery. The third (comparison group) included patients who didn`t use platelet-rich plasma lysate. To objectify the effect of platelet-rich plasma used the ultrasound method of research.

Results. An intergroup comparison at different times after surgery showed that in the Main 1 group, in which PRP was started intraoperatively, the relative thickness of the supraspinatus muscle on the side of the operation was significantly lower than in other groups. In a pairwise comparison in the group of patients without PRP and in patients of the 2nd main group (who were administered PRP n the 14^th day), the relative thickness of the supraspinatus muscle on the side of surgery after 1 month and after 1,5–2,5 months didn`t differ significantly from surgery.

Conclusions. Intraoperative use of platelet-rich plasma can reduce inflammatory changes in the tendons of the supraspinatus and subscapularis muscles, which is reliably confirmed by ultrasound data. 

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