Kidney transplantation in recipient with hyperhomocysteinemia: a case report
https://doi.org/10.20340/vmi-rvz.2024.2.CASE.3
Abstract
Introduction. There is an annual increasing of kidney transplantion all over the world. The number of recipients with hyperhomocysteinemia before and after the operation is also increasing, which increases the risk of cardiovascular complications, graft loss and patients’ death.
Materials and methods. A 28-year-old patient with terminal chronic renal desiase in the outcome of chronic glomerulonephritis had underwent an allogeneic kidney transplant from a 52-year-old donor, with confirmed brain death in the outcome of acute hemorrhagic cerebral circulatory disorders.
Results. The early postoperative period has complicated by thrombosis.
Conclusion. The study of blood homocysteine levels is mandatory when examining patients for kidney transplantation.
About the Authors
N. V. ZagorodnikovaRussian Federation
Natal'ya V. Zagorodnikova, Department of Kidney and Pancreas Transplantation
3, Bolshaya Sukharevskaya Square, Moscow, 129090
I. V. Dmitriev
Russian Federation
Il'ya V. Dmitriev, Doctor of Medical Sciences, Head of the Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute of Emergency Medicine; Department of Transplantation and Artificial Organs
3, Bolshaya Sukharevskaya Square, Moscow, 129090
1, Ostrovityanova str., Moscow, 117997
A. G. Balkarov
Russian Federation
Aslan G. Balkarov, Department of Kidney and Pancreas Transplantation; Department of Transplantology and Artificial Organs; Organizational and methodological Department of transplantation
3, Bolshaya Sukharevskaya Square, Moscow, 129090
1, Ostrovityanova str., Moscow, 117997
9, Sharikopodshipnikovskaya str., Moscow, 115088
Yu. A. Anisimov
Russian Federation
Yuriy A. Anisimov, Department of Kidney and Pancreas Transplantation; Department of Transplantology and Artificial Organs
3, Bolshaya Sukharevskaya Square, Moscow, 129090
20 Bldg. 1 Delegatskaya St., Moscow 127473
A. Yu. Bulanov
Russian Federation
Andrey Yu. Bulanov, Department of Biotechnology and Transfusiology
3, Bolshaya Sukharevskaya Square, Moscow, 129090
A. I. Kostin
Russian Federation
Aleksandr I. Kostin, Department of Clinical, Industrial Transfusiology and Gravitational Blood Surgery
3, Bolshaya Sukharevskaya Square, Moscow, 129090
N. V. Shmarina
Nonna V. Shmarina, Department of Kidney and Pancreas Transplantation; Department of Transplantology and Artificial Organs
3, Bolshaya Sukharevskaya Square, Moscow, 129090
1, Ostrovityanova str., Moscow, 117997
References
1. Paradkar MU, Padate B, Shah SAV, Vora H, Ashavaid T. Association of Genetic Variants with Hyperhomocysteinemia in Indian Patientswith Thrombosis. Indian J Clin Biochem. 2020;35(4):465–473. PMID: 33013017 https://doi.org/10.1007/s12291-019-00846-9
2. Cianciolo G, De Pascalis A, Di Lullo L, Ronco C, Zannini C, La Manna G. Folic Acid and Homocysteine in Chronic Kidney Disease and Cardiovascular Disease Progression: Which Comes First? Cardiorenal Med. 2017;7(4):255-266. PMID: 29118764 https://doi.org/10.1159/000471813
3. Reshetnyak T.M., Seredavkina N.V., Nasonov E.L. Hyperhomocysteinemia is a risk factor for thrombosis in antiphospholipid syndrome. Thrombosis, hemostasis, rheology. 2019;78(2):37-44. https://doi.org/10.25555/THR.2019.2.0878
4. Angelini A, Cappuccilli ML, Magnoni G, Croci Chiocchini AL, Aiello V, Napoletano A, et all. The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease. G Ital Nefrol. 2021;38(4): 2021-vol4. PMID: 34469084
5. Rossi GP, Seccia TM, Barton M, Danser AHJ, de Leeuw PW, Dhaun N, et al. Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Japanese Society of Hypertension. J Hypertens. 2018;36(3):462-471. PMID: 29135628 https://doi.org/10.1097/HJH.0000000000001600
6. Wu HHL, Wang AY. Vitamin B12 and chronic kidney disease. Vitam Horm. 2022;119:325-353. PMID: 35337625 https://doi.org/10.1016/bs.vh.2022.01.011
7. Langan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition and Management. Am Fam Physician. 2017;96(6):384-389. PMID: 28925645
Review
For citations:
Zagorodnikova N.V., Dmitriev I.V., Balkarov A.G., Anisimov Yu.A., Bulanov A.Yu., Kostin A.I., Shmarina N.V. Kidney transplantation in recipient with hyperhomocysteinemia: a case report. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2024;14(2):97-103. (In Russ.) https://doi.org/10.20340/vmi-rvz.2024.2.CASE.3