Functional magnetic resonance imaging in the assessment of changes in the brain connectome in children with cerebral palsy after the use of the neurorehabilitation suit «Reforma-ТЭКТ»
F. A. Tlizamova,
A. Yu. Efimtsev,
G. E. Trufanov,
D. S. Chegina,
I. S. Paleeva,
А. M. Klimovich,
A. P. Kochetova,
M. B. Skvortsova https://doi.org/10.20340/vmi-rvz.2025.2.MIM.1
Abstract
Background. Cerebral palsy is the leading cause of primary disability among neurological diseases in the Russian Federation, according to the Federal Bureau of Medical and Social Expertise of the Ministry of Labor of Russia. Resting-state functional MRI (rs-fMRI) is a modern neuroimaging technique that allows identification of functional changes in the brain connectome of children with cerebral palsy and tracking their reorganization during neurorehabilitation. This is critically important for developing effective treatment strategies and medical-social rehabilitation programs.
Objective. To evaluate the potential of resting-state functional MRI as a tool for analyzing the therapeutic efficacy of neurorehabilitation interventions using the specialized "Reforma-TЭKT" suit.
Object and methods. The study was performed using a 1.5 Tesla MR scanner. Changes in the functional connectivity of resting-state brain networks were analyzed in 30 patients with cerebral palsy before and after rehabilitation with the "Reforma-TЭKT" neurorehabilitation suit.
Results. Intergroup statistical analysis revealed significant differences (p < 0.05) in the functional connectivity of the default mode network in all 30 cerebral palsy patients compared to the control group. Dynamic assessment showed increased functional connectivity between the medial prefrontal cortex, lingual working network (left inferior frontal gyrus), right frontoparietal cortex, and right middle frontal gyrus. Simultaneously, decreased connectivity with components of the attention network was observed.
Conclusion. The use of resting-state functional MRI in patients with cerebral palsy enables detection of changes in the brain connectome. With correct methodological approach, this neuroimaging technology can serve as an objective tool for monitoring therapeutic efficacy. The results obtained in this study contribute to improving rehabilitation strategies for patients undergoing treatment for the consequences of perinatal central nervous system damage.
Keywords
Cerebral Palsy [D002547],
Functional Magnetic Resonance Imaging [D050428],
Connectome [D000077239],
Brain [D001921],
Children [D002648],
Neurorehabilitation [D000071939],
Rehabilitation Devices [D019651],
Dynamic Proprioceptive Correction [D000076417],
Neuroplasticity [D055594],
Motor Function [D009049],
Rehabilitation Medicine [D012046],
Neuroimaging [D055426],
Pediatric Cerebral Palsy [D002547 + D010372],
Functional Connectivity [D056228],
Therapeutic Garments [D005695 + D019651]
About the Authors
F. A. Tlizamova
Almazov National Medical Research Center
Russian Federation
Competing Interests:
Russian Federation
Fatima A. Tlizamova, Postgraduate student, Department of Radiation Diagnostics and Medical Imaging with Clinic, Institute of Medical Education
2, Akkuratova St., St. Petersburg, 197341
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
A. Yu. Efimtsev
Almazov National Medical Research Center
Russian Federation
Competing Interests:
Russian Federation
Aleksandr Yu. Efimtsev, Dr. Sci. (Med.), Associate Professor Department of Radiation Diagnostics and Medical Imaging with Clinic, Institute of Medical Education
2, Akkuratova St., St. Petersburg, 197341
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
G. E. Trufanov
Almazov National Medical Research Center
Russian Federation
Competing Interests:
Russian Federation
Gennadiy E. Trufanov, Dr. Sci. (Med.), Professor, Head of the Department of Radiation Diagnostics and Medical Imaging with Clinic of the Institute of Medical Education
2, Akkuratova St., St. Petersburg, 197341
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
D. S. Chegina
Almazov National Medical Research Center
Russian Federation
Competing Interests:
Russian Federation
Dar'ya S. Chegina, Cand. Sci. (Med.), Radiologist, MRI Department
2, Akkuratova St., St. Petersburg, 197341
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
I. S. Paleeva
Almazov National Medical Research Center
Russian Federation
Competing Interests:
Russian Federation
Irina S. Paleeva, Resident, Department of Radiation Diagnostics and Medical Imaging with Clinic of the Institute of Medical Education
2, Akkuratova St., St. Petersburg, 197341
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
А. M. Klimovich
Almazov National Medical Research Center
Russian Federation
Competing Interests:
Russian Federation
Anastasiya M. Klimovich, Resident of the Department of Radiation Diagnostics and Medical Imaging with the Clinic of the Institute of Medical Education
2, Akkuratova St., St. Petersburg, 197341
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
A. P. Kochetova
School No. 627 of the Nevsky District of St. Petersburg
Russian Federation
Competing Interests:
Russian Federation
Anna P. Kochetova, Cand. Sci. (Ped.), Principal
11, Novoselov St., St. Petersburg, 193079
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
M. B. Skvortsova
School No. 627 of the Nevsky District of St. Petersburg
Russian Federation
Competing Interests:
Russian Federation
Mariya B. Skvortsova, Deputy Director for Educational Work of the VR
11, Novoselov St., St. Petersburg, 193079
Competing Interests:
Авторы заявляют об отсутствии конфликта интересов
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Tlizamova F.A., Efimtsev A.Yu., Trufanov G.E., Chegina D.S., Paleeva I.S., Klimovich А.M., Kochetova A.P., Skvortsova M.B. Functional magnetic resonance imaging in the assessment of changes in the brain connectome in children with cerebral palsy after the use of the neurorehabilitation suit «Reforma-ТЭКТ». Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2025;15(2):189-197. (In Russ.) https://doi.org/10.20340/vmi-rvz.2025.2.MIM.1
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