Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease
https://doi.org/10.20340/vmirvz.2021.2.CLIN.5
Abstract
The research was aimed at the investigation of systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease. We examined 42 patients with no clinical symptoms but at high risk of knee osteoarthrosis, and 12 donors with no musculoskeletal pathologies. It was established that systemic abnormalities featured by the negative change in the cell immunity along with pro-inflammatory cytokine activation were detectable even in the early stage of primary osteoarthrosis. These had probably facilitated the progress of the immune response followed by the inflammatory reaction that led to the progress of destructive changes in the connective tissue structures of the knees4 the process was proven by the increase in cartilage oligomeric matrix protein as well as cartilage glycoprotein-39.
About the Authors
S. V. Belova
Research Institute of Traumatology, Orthopedics and Neurosurgery,Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Saratov
E. V. Gladkova
Research Institute of Traumatology, Orthopedics and Neurosurgery, Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Saratov
R. A. Zubavlenko
Research Institute of Traumatology, Orthopedics and Neurosurgery, Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Saratov
V. Yu. Ulyanov
Research Institute of Traumatology, Orthopedics and Neurosurgery, Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Saratov
References
1. Shirinskij V.S., Kazy`gasheva E.V., Shhirinskij I.V. Vospalenie i immunitet: rol' v patogeneze osteoartrita. Medicinskaya immunologiya. 2019;21(1):39-48. (In Russ).
2. Castaneda S., Roman-Blas J.A., Largo R. et al. Osteoarthritis: a progressive disease with changing phe-notypes. Rheumatology. 2014;53(6):1-3. https://doi.org/10.1093/rheumatology/ket247.
3. Kczoeva A.A. Rol' xryashhevogo glikoproteina-39 u bol'ny'x osteoartrozom kolennogo sustava v so-chetanii s ishemicheskoj bolezn`yu serdcza, arterial'noj gipertenziej i dislipidemiej. Terapiya. 2018;3(21):72-77. (In Russ).
4. Kragstrup T.W., Sohn D.H., Lepus C.M. et al. Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis. BMC Rheumatol. 2019;2(3).Art. № 46. https://doi.org/10.1186/s41927-019-0093-4.
5. Kandahari A.M., Yang X., Dighe A.S. et al. Recognition of immune response for the early diagnosis and treatment of osteoarthritis. J. Immunol. Res. 2015. Art. ID 192415. https://doi.org/10.1155/2015/192415.
6. CHepeleva M.V., CHegurov O.K., Kuznecova E.I. Koncentracii citokinov v perifericheskoj krovi i sinovi-al'noj zhidkosti pacientov s deformiruyushchim osteoartrozom kolennogo sustava v zavisimosti ot veli-chiny defekta vnutrennego myshchelka bol'shebercovoj kosti. Genij Ortopedii. 2017;23(4):450-454. (In Russ).
7. Jaime P., Garcia-Guerrero N., Estella R. et al. CD56+/CD16– natural killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis. Osteoarthritis carti-lage. 2017;25(10):1708-1718. https://doi.org/10.1016/j.joca.2017.06.007.
8. Nasonov E.L., Aleksandrova E.N., Novikov A.A. Autoimmunnye revmaticheskie zabolevaniya – problemy immunopatologii i personificirovannoj terapii. Vestnik RAMN. 2015;70(2):169-182. https://doi.org/10.15690/vramn.v70i2.1310 (In Russ).
9. SHirinskij I.V., Kalinovskaya N.YU., SHirinskij V.S. Kliniko-immunologicheskaya harakteristika diabet-associirovannogo osteoartrita. Medicinskaya immunologiya. 2015;17(1):87-92. https://doi.org/10.15789/1563-0625-2015-1-87-92 (In Russ).
10. Vasil'eva L.V., Lahin D.I. Vliyanie metabolicheskogo sindroma na klinicheskuyu kartinu osteoartroza. Medicinskij vestnik Severnogo Kavkaza. 2017;12(1):8-10. http://doi.org/10.14300/mnnc.2017.12002 (In Russ).
11. Belova YU.S. Karyakina E.V. Hryashchevoj protein pri razlichnyh tipah displazii. Russkij medicinskij zhurnal. 2017;25(19):1352-1355. (In Russ).
12. Tyurin A.V. Klinicheskie osobennosti i molekulyarno-geneticheskie aspekty osteoartroza u bol'nyh s displaziej soedinitel'noj tkani: avtoref. dis. … kand. med. nauk. Moscow; 2015. 23 с. (In Russ).
Supplementary files
Review
For citations:
Belova S.V., Gladkova E.V., Zubavlenko R.A., Ulyanov V.Yu. Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2021;(2):71-78. (In Russ.) https://doi.org/10.20340/vmirvz.2021.2.CLIN.5
Views:
343
Email this article 