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Results of allogeneic hematopoietic stem cell transplantation in a patient with classical Hodgkin's lymphoma

https://doi.org/10.20340/vmi-rvz.2021.2.TX.1

Abstract

The aim of the study was to study the role of allogeneic transplantation of hematopoietic stem cells in a patient with the classic course of Hodgkin's lymphoma.

Materials and methods. The work was carried out on the basis of the analysis of a clinical case of the clinic of occupational pathology and hematology of the University Clinical Hospital No. Professor V.Ya. Shustov. Examinations, a course of chemotherapy in conjunction with surgery and analysis of the results of a patient with a diagnosis of classic Hodgkin's lymphoma were carried out. 

Results. An unfavorable prognostic effect of a large amount of previous chemotherapy on overall survival after allogeneic HSC transplantation was revealed. According to the results of PET-CT, the patient achieved PETnegative remission of the disease after all the stages of treatment. Compared to the presented PET / CT scan of 02/07/2020, there is a positive trend in the form of the disappearance of metabolic activity in the 3rd rib on the right, the body of Th 11 and the body of the left ilium.

Conclusion. The use of high-dose chemotherapy with hematopoietic stem cell transplantation makes it possible to achieve success in the treatment of patients in cases where the results of chemotherapy are unsatisfactory.

About the Authors

A. Р. Strelnikova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Saratov



E. V. Sarksyan
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Saratov



V. S. Bogova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Saratov



A. N. Levanov
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Saratov



Т. V. Shelekhova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Saratov



N. I. Lviv
Saratov State Medical University named after V.I. Razumovsky
Russian Federation

Saratov



References

1. Chang Y.-J., Huang X.-J. Use of G-CSFstimulated marrow in allogeneic hematopoietic stem cell transplanta tion settings: a comprehensive review. Clin Transplant. 2011;25(1):13-23.

2. Learning Radiology: Recognizing the Basics, 3e 3rd Edition by William Herring

3. Rutella S., Zavala F., Danese S. et al. Granulocyte colony-stimulating factor: a novel mediator of T-cell toler ance. J Immunol. 2005;175(11):7085-91.

4. Vysokodoznaya himioterapiya i transplantaciya kostnogo mozga u vzroslyh bol'nyh. Protivorakovoe ob shchestvo Rossii. URL: http://www.pror.ru/treatment/transplantation

5. CHesnokova N.P., Morrison V.V., Nevvazhaj T.A. et al. Gemopoez i ego regulyaciya na razlichnyh stadiyah differencirovki gemopoeticheskih kletok kostnogo mozga. Saratovskij nauchno-medicinskij zhurnal. 2012;8(3):711-719.

6. Zacepin S.T. Kostnaya patologiya vzroslyh: rukovodstvo dlya vrachej. Moscow, 2001. 640 s.

7. Machneva E.B., Panarina V.YU., Aliev T.Z. et al. Hronicheskaya reakciya «transplantat protiv hozyaina» posle allogennoj transplantacii gemopoeticheskih stvolovyh kletok: osnovnye harakteristiki, patogeneticheskie mekhanizmy, strategii terapii i problemy klinicheskoj praktiki. Rossijskij zhurnal detskoj gematologii i onkologii. 2020;7(2):94-111.

8. CHesnokova N.P., Morrison V.V., Bril' G.E. et al. Obshchaya patologiya. Moscow, 2006.

9. Uss A.L. Transplantaciya stvolovyh gemopoeticheskih kletok pri limfome Hodzhkina. Zdravoohranenie. 02.02.2016. URL:.http://www.zdrav.by/transplantologiya/transplantatsiya-stvolovyh-gemopoeticheskih kletok-pri-limfome-hodzhkina/


Review

For citations:


Strelnikova A.Р., Sarksyan E.V., Bogova V.S., Levanov A.N., Shelekhova Т.V., Lviv N.I. Results of allogeneic hematopoietic stem cell transplantation in a patient with classical Hodgkin's lymphoma. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2021;(2):113-121. (In Russ.) https://doi.org/10.20340/vmi-rvz.2021.2.TX.1

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ISSN 2226-762X (Print)
ISSN 2782-1579 (Online)