Features of the clinical course of arterial hypertension in alien residents of Western Siberia with the establishment of patterns of metabolic changes

Metabolic syndrome is considered as a polyetiological disease that makes a significant contribution to the increase in mortality from vascular accidents. The combination of metabolic syndrome and arterial hypertension is a complex pathogenetic duet, the diagnosis and treatment of which continues to be actively discussed.

The aim of the study was to study the metabolic syndrome in patients with arterial hypertension permanently residing in the Far North, the frequency of occurrence of the main variants of the metabolic syndrome depending on the degree of hypertension in comparison between men and women.

Material and methods. The study was conducted in the Khanty-Mansiysk Autonomous Okrug – YUGRA, the study period: September 2017 – November 2018. The study involved 205 patients permanently residing in the Far North: men – 82 people (40 %), women – 123 people (60 %). By age, patients are represented by two groups: group 1 – 38–43 years old (n = 98), of which 46 men (46.9 %), women – 52 people (53.1 %); group 2 – 44–50 years old (n = 107), of which 46 men (43 %), women – 61 people (57 %). By degree of AH: 1st degree AH (n = 38), including 14 men (36.84 %), 24 women (61.16 %); 2nd degree AH (n = 115), men – 53 people (46.1 %), women – 62 people (53.9 %); 3 degree AH (n = 52), men – 21 people (40.38 %), women – 31 people (59.62 %).

Results – statistically significant variants of the metabolic syndrome were identified for patients with arterial hypertension living in harsh climatic and geographical conditions, an analysis of these variants was carried out in comparison between men and women, depending on the age and degree of arterial hypertension. 

1. Drapkina OM, Eliashevich SO, Shepel RN. Obesity as a risk factor for chronic noncommunicable diseases. Russ J Cardiol. 2016;6(134):73-9. (In Russ). https://doi.org/10.15829/1560-4071-2016-6-73-79

2. Shalnova SA, Deev AD, Balanova Yu.A., et al. Twenty-year trends in obesity and arterial hypertension and their associations in Russia. Cardiovascular therapy and prevention. 2017;16(4):4-10 (In Russ). https://doi.org/10.15829/1728-8800-2017-4-4-10

3. Rotar OP, Libis RA, Isaeva EN, et al. Metabolic syndrome prevalence in Russian cities. Russian Journal of Cardiology. 2012;(2):55-62. (In Russ). https://doi.org/10.15829/1560-4071-2012-2-55-62

4. Simonova GI, Pechenkina EA, Shcherbakova LV et al. Prevalence of metabolic syndrome and its components in Siberia. Actual issues of diagnosis and treatment of metabolic syndrome: abstracts of the conference. Moscow, 2006;17 (In Russ).

5. Nebesnykh AL. The characteristics of metabolic syndrome manifestations in different ethnic groups. Sibirskiy meditsinskiy zhurnal. 2013:(7)19-23 (In Russ).

6. Nikitin YP, Voevoda МI, Simonova GI. Diabetes mellitus and metabolic syndrome in Siberia and in the Far East. Vestnik RAMN. 2012;67(1):66-74 (In Russ).

7. Oganov RG, Simanenkov VI, Bakulin IG et al. Comorbid pathology in clinical practice. Diagnostic and treatment algorithms. Cardiovascular Therapy and Prevention. 2019;18(1):5-66 (In Russ). https://doi.org/10.15829/1728-8800-2019-1-5-66

8. Recommendations for the management of patients with metabolic syndrome. Clinical guidelines Ministry of Health of the Russian Federation. 2013(43). (In Russ). URL: https://mzdrav.rk.gov.ru/file/mzdrav_18042014_Klinicheskie_rekomendacii_Metabolicheskij_sindrom.pdf

9. Health of the population of Russia: the impact of the environment in a changing climate / ed. ed. academician A.I. Grigoriev; The Russian Academy of Sciences. Moscow: Nauka, 2014;428. (In Russ).

10. Khasnulin V.I., Khasnulina A.V. Individual features of metabolic characteristics and resistance to psycho-emotional stress in the North. World of Science, Culture, Education. 2012;4;295–299. (In Russ).

11. Zapesochnaya I.L., Avtandilov A.G. The problem of adaptation of the cardiovascular system when living in the Far North: study guide. Moscow:: GBOU DPO RMAPO, 2015; 127. (In Russ).