ASSESSMENT OF MARKERS OF HEMOSTASIS AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PROGRESSIVE OBLITERATING LOWER LIMB ATHEROSCLEROSIS
Abstract
We performed a comprehensive evaluation of the hemostatic system and markers of endothelial dysfunction in patients with obliterating lower limb atherosclerosis involving the femoral-popliteal-tibial segment. Progressive course of obliterating atherosclerosis is associated with hypercoagulation (increased platelet aggregation activity, shortened aPTT, PT, TT, increased levels of fibrinogen, SFMCs, and D-dimer), as well as with endothelial dysfunction (increased levels of endothelin-1, von Willebrand factor, homocysteine, and Creactive protein).
About the Authors
E. A. Korymasov
Federal State Budgetary Institution of Higher Education ‘Samara State Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Samara
Russian Federation
Samara
E. P. Krivoshchekov
Federal State Budgetary Institution of Higher Education ‘Samara State Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Samara
Russian Federation
Samara
A. V. Kazantsev
Federal State Budgetary Institution of Higher Education ‘Samara State Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Samara
Russian Federation
Samara
D. L. Pribytkov
State Budgetary Healthcare Institution ‘V.D. Seredavin Samara Regional Clinical Hospital‘
Russian Federation
Samara
Russian Federation
Samara
P. N. Zolotarev
Private Institution of Higher Education ‘Medical University ‘Reaviz’
Russian Federation
Samara
Russian Federation
Samara
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Review
For citations:
Korymasov E.A., Krivoshchekov E.P., Kazantsev A.V., Pribytkov D.L., Zolotarev P.N. ASSESSMENT OF MARKERS OF HEMOSTASIS AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PROGRESSIVE OBLITERATING LOWER LIMB ATHEROSCLEROSIS. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(3):138-145. (In Russ.)
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