Treatment of severe arterial limb ischemia in patients with multifocal atherosclerosis and chd infusion of 0.01 % nitroglycerin solution
A. N. Shcherbyuk,
V. L. Lemenev,
B. I. Yaremin,
V. M. Manuylov,
Ya. E. Nemstsveridze,
R. I. Stepanova,
L. R. Derbina https://doi.org/10.20340/vmi-rvz.2023.4.CLIN.1
Abstract
Occlusive lesions of the main arteries of the extremities are a common and severe disease that leads to disability and has a high rate of death [1]. Many different drugs are known for the treatment of this pathology, however, despite the large number of pharmacological drugs and conservative treatment methods, surgical methods of treatment are the most effective in terms of saving the limb [3, 4]. However, methods of conservative therapy continue to be the most important component of the treatment of arterial limb ischemia, which requires the development of more effective methods. As a result of the use of intravenous administration of a 0.01 % solution of nitroglycerin for the treatment of arterial ischemia of the extremities in patients with coronary artery disease, it was possible to obtain good immediate results in an average of 57.3 % of cases.
Supporting agencies: This research received no external funding
About the Authors
A. N. Shcherbyuk
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
Russian Federation
Competing Interests:
Russian Federation
Aleksandr N. Shcherbyuk - Dr. Sci. (Med.), Professor, Department of Surgery.
61/2 Shchep-kina, Moscow, 129110
Competing Interests:
none
V. L. Lemenev
Sklifosovsky N.V. Research Institute of Emergency Medicine
Russian Federation
Competing Interests:
Russian Federation
Vladimir L. Lemenev - Dr. Sci. (Med.), Professor, Laureate of the State Prize of the Russian Federation, Honored Doctor of the Russian Federation, Scientific consultant.
3 Bolshaya Sukharevskaya Square, Moscow, 129090
Competing Interests:
none
B. I. Yaremin
Moscow Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Boris I. Yaremin - Vice-Rector for Clinical Work, Head of the Department of Surgical Diseases.
2 Krasnobogatyrskaya str., p. 2, Moscow, 107564
Competing Interests:
B.l. Yaremin is the executive secretary of the editorial board of the journal. They did not take part in the decision to publish the work
V. M. Manuylov
Moscow Regional Hospital named after prof. Rozanova V.P.
Russian Federation
Competing Interests:
Russian Federation
Vladimir M. Manuylov - Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Chief Physician.
35 Aviation, Pushkino, Moscow region, 141206
Competing Interests:
none
Ya. E. Nemstsveridze
Moscow Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Yakov E. Nemstsveridze - 4th year student of the Faculty of Dentistry.
2 Krasnobogatyrskaya str., p. 2, Moscow, 107564
Competing Interests:
none
R. I. Stepanova
Moscow Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Regina I. Stepanova - 4th year student of the Faculty of Dentistry.
2 Krasnobogatyrskaya str., p. 2, Moscow, 107564
Competing Interests:
none
L. R. Derbina
Center of Modern Medicine "PROFMED"
Russian Federation
Competing Interests:
Russian Federation
Larisa R. Derbina - General Director.
Gorky str., 7, office 1-29, Moscow region, Khimki, 141421
Competing Interests:
none
References
1. Abdel'latif А.М., Shuvalova Yu.A., Slivkina A.A., Kaminnyy A.I. The effect of metabolic syndrome on the long-term prognosis of patients with acute myocardial infarction with ST segment elevation. Atherosclerosis and dyslipidemia. 2016; 1:68-75. (In Russ)].
2. Abdulkerimova A.A., Chichkova M.A., Kovalenko N.V. Prognostic factors for the development of acute heart failure in patients with Q-myocardial infarction. Modern problems of science and education (electronic journal). 2015;1-1:1302. (In Russ).
3. 3 Boytsov S.A., Samorodskaya I.V., Nikulina N.N., Yakushin S.S., Andreev E.M., Zarat'yants O.V., Barbarash O.L. Comparative analysis of population mortality from acute forms of coronary heart disease over a fifteen-year period in the Russian Federation and the USA and factors influencing its formation. Therapeutic archive (archive up to 2018). 2017;89(9):53-59. (In Russ).
4. 4 Bokeriya L.A., Gudkova R.G. Cardiovascular surgery – 2016. Diseases and congenital anomalies of the circulatory system. Moscow: NTSSSH im. A.N. Bakuleva RAMS. 2017;198. (In Russ).
5. 5 Boldueva S.A., Evdokimov D.S. Coronary heart disease: angina pectoris: teaching aid. St. Petersburg: SZGMU im. I.I. Mechnikov. 2021;92. (In Russ).
6. 6 Vyaznikov V.A. Acute arterial obstruction: study guide. Kirov: Kirov State Medical University. 2021;90. (In Russ).
7. 7 Dedov D.V. The value of quality of life parameters in a comprehensive assessment of the effectiveness of interventional and conservative treatment of patients with coronary heart disease. Tver Medical Journal. 2015;4:131-135. (In Russ).
8. 8 Makolkin V.I., Ovcharenko S.I., Sulimov V.A. Internal diseases: textbook. 6th ed., revised and additional. Moscow: GEOTAR-Media, 2017:768. (In Russ).
9. 9 Maksimov A.V., Korejba K.A. Critical ischemia of the lower extremities in patients of the department of purulent-septic surgery. Angiology and vascular surgery. 2016;2:152-155. (In Russ).
10. 10 Nagibina Ju.V., Zaharova L.A. Coronary heart disease (CHD) occupies medical and social characteristics of patients with coronary heart disease and quality of life. Russian Journal of Cardiology. 2017;3(143):155-159. (In Russ).
11. 11 National guidelines for the management of patients with diseases of the arteries of the lower extremities. M., 2013:189. (In Russ).
12. 12 Nepomnjashhih R.D., Karpova A.A., Bakarev M.A., Nepomnjashhih L.M. Comparative analysis of risk factors for the development of acute myocardial infarction and chronic ischemic disease. Fundamental aspects of compensatory-adaptive processes, molecular-cellular and medical-ecological problems of compensation and adaptation. 2015:184-185. (In Russ).
13. 13 Olesin A.I., Konstantinova I.V., Zueva Yu.S. Ischemic heart disease: angina – diagnosis and treatment: teaching aid. St. Petersburg: SZGMU im. I.I. Mechnikov. 2021:72. (In Russ).
14. 14 Orlova A.Ju., Sukovatyh B.S., Artjushkova E.B., Gordov M. Ju. Effect of actovegin and solcoseryl on microcirculation in critical ischemia of the lower extremities in the experiment. Angiology and vascular surgery. 2017;1:29-35. (In Russ).
15. 15 Mel'nikov M.V., Ivanov M.A., Mel'nikov M.V., Koshelev T.E. Acute limb ischemia: a textbook. St. Petersburg: SZGMU im. I.I. Mechnikov. 2022:48. (In Russ).
16. 16 Samorodskaya I.V., Boytsov S.A., Zayrat'yants O.V., Andreev E.M. Comparison of mortality rates from coronary heart disease among men and women over 50 in Russia and the USA. Russian journal of cardiology. 2017;6(146):100-106. (In Russ).
17. 17 Safronova E.A., Kuzin A.I., Shamaeva T.N., Zapol'skikh L.G. Arrhythmogenic effect of nitroglycerin in patients with stable angina of functional class 1 and 2. Modern problems of science and education. 2019;2:56-58. (In Russ).
18. 18 Chuchalin A.G., Bobkov E.V. Clinical diagnostics: textbook. Moscow: GEOTAR-Media. 2018:736. (In Russ).
19. 19 Shabunin A.V., Matveev D.V., Kuznetsov M.R. Objective assessment of the degree of ischemia and the effectiveness of treatment in chronic arterial insufficiency of the lower extremities. Angiology and vascular surgery. 2018;4:177-182. (In Russ).
20. 20 Shikhverdiev N.N., Kupatadze D.D., Badurov R.B. Congenital heart defects in adults: textbook. St. Petersburg: SPbGPMU, 2021; 7:67-69. (In Russ).
21. 21 Colwell J.A., Nesto R.W. The platelet in diabetes: focus on prevention of ischemic events. Diabetes Care. 2013;26:2181–2188.
22. 22 Olinic D.M., Stanek A., Tataru D.A., Homorodean C., Olinic M. Acute limb ischemia: an update on diagnosis and management. J Clin Med. 2019;8(8):1215.
23. 23 Teraa M., Conte M.S., Moll F.L., Verhaar M.C. Critical Limb Ischemia: Current Trends and Future Directions. J Am Heart Assoc. 2016;5(2).
24. 24 Veerasuri S., Kulkarni S.R., Wilson W.R., Paravastu S.CV. Bilateral acute lower limb ischemia secondary to COVID-19. Vasc Endovascular Surg. 2020;55(2):196–199.
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For citations:
Shcherbyuk A.N., Lemenev V.L., Yaremin B.I., Manuylov V.M., Nemstsveridze Ya.E., Stepanova R.I., Derbina L.R. Treatment of severe arterial limb ischemia in patients with multifocal atherosclerosis and chd infusion of 0.01 % nitroglycerin solution. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2023;13(4):32-38. (In Russ.) https://doi.org/10.20340/vmi-rvz.2023.4.CLIN.1
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