The effect of the aqueous extract of reddish hellebore on the emotional state of the offspring of rats
https://doi.org/10.20340/vmi-rvz.2023.4.PHYS.2
Abstract
Anxiety is a natural survival mechanism that helps to cope with potentially dangerous situations. It is accompanied by changes in the functioning of the nervous and endocrine systems, which affect the behavior of living beings. It is possible to establish the level of anxiety and the severity of depression thanks to various behavioral methods, with the help of which it is possible to fix indicators, establish their duration, and then compare data on the emotional state of animals from the control and experimental groups. The purpose of the study: to identify the features of the emotional state of the offspring of rats that received an aqueous plant extract of reddish hellebore. Conclusions: aquatic plant extract of reddish hellebore has a modeling effect that reduces the level of anxiety and depression.
Keywords
rat anxiety level,
elevated maze method,
rat depression level,
forced swimming test,
reddish hellebore
Supporting agencies: This research received no external funding
About the Authors
S. N. Klychkova
Samara State Medical University
Russian Federation
Competing Interests:
Russian Federation
Svetlana N. Klychkova - Senior lecturer of the Department of Physiology with the course of safety-news of vital activity and disaster medicine.
89 Chapaevskaya str., Samara, 443099
Competing Interests:
none
O. N. Pavlova
Samara State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga N. Pavlova - Dr. Sci. (Biol.), Associate Professor, Head of the Department of Physiology with the course of Life Safety and Disaster Medicine.
89 Chapaevskaya str., Samara, 443099
Competing Interests:
Author O.N. Pavlova is the head of the editorial office of the magazine. She did not participate in the review of this work
O. N. Gulenko
Samara State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga N. Gulenko - Cand. Sci. (Biol.), Docent, Associate Professor of the Department of Physiology with the course of life safety and Disaster Medicine.
89 Chapaevskaya str., Samara, 443099
Competing Interests:
none
O. V. Gerasimova
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Gerasimova Olga Valeryevna - Cand. Sci. (Biol.), Associate Professor of the Department of Biomedical Sciences.
227 Chapaevskaya str., Samara, 443001
Competing Interests:
none
A. V. Kolesnikov
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Kolesnikov Anatoly Vladimirovich - Cand. Sci. (Biol.), Associate Professor of the Department of Biomedical Sciences.
227 Chapaevskaya str., Samara, 443001
Competing Interests:
none
V. V. Maslyakov
Saratov State Medical University named after V.l. Razumovsky
Russian Federation
Competing Interests:
Russian Federation
Vladimir V. Maslyakov - Dr. Sci. (Med.), Professor Department of Mobilization Training in Public Health and Disaster Medicine.
12 B. Cossack, Saratov, 410012
Competing Interests:
none
References
1. 1 Mamylina N.V., Pavlova V.I. Physiological aspects of behavioral activity of animals under emotional stress: monograph. Chelyabinsk. 2013:298. (In Russ).
2. 2 Pavlova O.N., Gulenko O.N., Temkin M.L., Zhelonkin N.N., Devyatkin A.A., Kanaeva E.S., Khabibullina T.V. Study of the emotional state of the offspring of rats treated with aqueous plant extracts. International Scientific Research Journal. 2022;11. (In Russ).
3. 3 Kaluev A.V. Studying anxiety in animals – yesterday, today, tomorrow. Stress and behavior: Materials of the 7th Interdisciplinary Conference on Biological Psychiatry. M. 2003;145–148. (In Russ).
4. 4 Kade A.H., Kravchenko S.V., Trofimenko A.I., Polyakov P.P., Lipatova A.S., Ananyeva E.I., etc. Modern methods of assessing the level of anxiety of rodents in behavioral tests based on models without prior conditioning. Kuban Scientific Medical Bulletin. 2018;25(6):171—176. (In Russ).
5. Lyubimov В.I. et al. Methodological recommendations for the preclinical study of the reproductive toxicity of pharmacological agents. Biomedical Journal Medline. ru. 2006. 26 Nov. URL: http://www.medline.rU/public/fund/pharmcom/4.phtmlom/4.phtml (In Russ)].
6. Sudakov S.K., Nazarova G.A., Alekseeva E.V., Bashkatova V.G. Determination of anxiety level in rats in the tests "open field", "cruciform raised maze" and the Vogel test. Byul. exp. biology and medicine. 2013;155(3):268-270. (In Russ)].
7. Grigoryan G.A., Gulyaeva N.V. Modeling depression on animals: behavior as the basis of methodology, evaluation criteria and classification. GNI Magazine. 2015;65(6):643-660. (In Russ).
8. Yauzina N.A., Komleva Yu.К., Salmina А.В., Petrova M.M., Morozova G.A., Malinovskaya N.A., Duke G.E. Modern experimental models of depression. Biomedicine. 2013; 1:61 —71. (In Russ).
Review
For citations:
Klychkova S.N., Pavlova O.N., Gulenko O.N., Gerasimova O.V., Kolesnikov A.V., Maslyakov V.V. The effect of the aqueous extract of reddish hellebore on the emotional state of the offspring of rats. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2023;13(4):27-31. (In Russ.) https://doi.org/10.20340/vmi-rvz.2023.4.PHYS.2
Views:
219
Email this article 