On the issue of telocytes of skin
https://doi.org/10.20340/vmi-rvz.2020.4.15
Abstract
This manuscript is devoted to the description of a new population of interstitial cells – telocytes discovered by L.M. Popescu and M.S. Faussone-Pellegrini. Later telocytes were found in the dermis, where they perform an important metabolic function and maintain homeostasis. Telocytes are small cells with a large elongated nucleus and a small amount of cytoplasm, which contains long cellular prolongations made of thin (podomeres, 40–100 nm) and thick (pods, 200–500 nm) segments – telopodes. Based on the results of morphological studies, it was possible to reliably differentiate telocytes from fibroblasts. During immunostaining they express CD34 and PDGFRα. Nevertheless, despite the numerous studies carried out regarding the role of telocytes, their function in the skin remains unclear and requires further investigations.
About the Author
A. Yu. Tcibulevsky
Private Institution of Higher Education ‘Moscow Medical University ‘Reaviz’
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Popescu LM, Faussone-Pellegrini MS. Telocytes – a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to telocytes. J Cell Mol Med. 2010 Apr;14(4):729-40. doi: 10.1111/j.1582-4934.2010.01059.x.
2. Faussone Pellegrini MS, Popescu LM. Telocytes. Biomol Concepts. 2011;2(6):481–9.
3. Ceafalan L, Gherghiceanu M, Popescu LM, Simionescu O. Telocytes in human skin – are they involved in skin regeneration? J Cell Mol Med. 2012;16(7):1405–20., Manole CG, Gherghiceanu M, Simionescu O. Telocyte dy-namics in psoriasis. J Cell Mol Med.2015;19(7):1504–19.
4. Vannucchi MG, Traini C, Guasti D, Del Popolo G, Faussone-Pellegrini MS. Tel-ocytes sub- types in human urinary bladder. J Cell Mol Med. 2014;18(10):2000–8.
5. Chang Y, Li C, Lu Z, Li H, Guo Z. Multiple immunophenotypes of cardiac telo-cytes. Exp Cell Res. 2015;338(2):239–44.
6. Ceafalan L, Gherghiceanu M, Popescu LM, Simionescu O. Telocytes in human skin – are they involved in skin regeneration? J Cell Mol Med. 2012;16(7):1405–20.
7. Manole CG, Gherghiceanu M, Simionescu O. Telocyte dynamics in psoriasis. J Cell Mol Med.2015;19(7):1504–19.
8. Manole CG, Simionescu O. The Cutaneous Telocytes. Adv Exp Med Biol. 2016;913:303-323. doi: 10.1007/978-981-10-1061-3-20.
9. Manetti M, Guiducci S, Ruffo M, Rosa I, Faussone-Pellegrini MS, Matucci-Cerinic M, Ibba-Manneschi L. Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis. J Cell Mol Med. 2013;17(4):482–96.
Review
For citations:
Tcibulevsky A.Yu. On the issue of telocytes of skin. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(4):135-136. (In Russ.) https://doi.org/10.20340/vmi-rvz.2020.4.15
Views:
707
Email this article 