Difficulties in diagnostics of genital tuberculosis
https://doi.org/10.20340/vmi-rvz.2025.3.CASE.3
Abstract
Genital tuberculosis is a specific lesion of the female genital organs by an infection caused by mycobacteria of the Mycobacteriaceae family. The disease is most often registered in reproductive age, the leading complaints are infertility, menstrual irregularities, pelvic pain. Diagnosis of tuberculosis of the female genital organs is a complex task: the absence of specific clinical symptoms, the duration of the course, as well as the low level of alertness of doctors and patients do not always allow for a timely diagnosis and the beginning of appropriate treatment. In addition, patients with infertility against the background of undiagnosed genital tuberculosis can be subjected to assisted reproductive technology procedures. In the article, we present a clinical example of a patient with secondary infertility against the background of tuberculous lesions of the uterine appendages demonstrating all of the above.
About the Authors
M. A. AndrianovBelarus
Maksim A. Andrianov - General practitioner
Author's contribution: article concept and design, review of publications on the topic of the article, collection and processing of material.
83, Dzerzhinsky Ave., Minsk, 220083
Competing Interests:
The authors declare no competing interests.
A. K. Davletova
Russian Federation
Anara Kayratovna Davletova - Clinical resident of the 1st year of study, special faculty
Author's contribution: review of publications on the topic of the article, collection and processing of material.
6, Klinicheskaya St., Saint Petersburg, 194044
Competing Interests:
The authors declare no competing interests.
T. E. Kurmanbaev
Russian Federation
Timur E. Kurmanbaev - Cand. Sci. (Med.), senior lecturer, Department of Obstetrics and Gynecology
Author's contribution: review of publications on the topic of the article, writing the text.
6, Klinicheskaya St., Saint Petersburg, 194044
Competing Interests:
The authors declare no competing interests.
L. E. Albegova
Russian Federation
Lyubov' E. Albegova - Obstetrician-gynecologist of Department No. 4 for patients with extrapulmonary tuberculosis
Author's contribution: collection and processing of material, writing the text of the article.
93, Torez Ave., Saint Petersburg, 194214
Competing Interests:
The authors declare no competing interests.
E. T. Nurmukhametova
Russian Federation
El'mira T. Nurmukhametova - Cand. Sci. (Med.), Associate Professor of the Department of Obstetrics and Gynecology with a course in endoscopic surgery
Author's contribution: collection and processing of material.
227, Chapaevskaya St., Samara, 443001
Competing Interests:
The authors declare no competing interests.
References
1. Kulchavenya E.V. Tuberculosis of female genital organs. Clinical lecture. Gynecology. 2022;24(5):413–420(In Russ.). DOI: https://doi.org/ 10.26442/ 207956 96. 20 22.5.201818
2. Tjahyadi D., Ropii B., Tjandraprawira K. D., Parwati I., Djuwantono T., Permadi W., Li T. Female genital tuberculosis: clinical presentation, current diagnosis, and treatment. Infectious Diseases in Obstetrics and Gynecology, 2022(1): 3548190. DOI: https://doi.org/ 10.1155/2022/3548190
3. Kayukova S.I., Ochirova S.O., Sinyatkina V.V., Karpina N.L., Uvarova E.V., Mikhaleva L.M. Diagnosis and treatment of chronic endometritis in women with tuberculosis of the respiratory organs. Obstetrics and Gynecology. 2024; 10:11-18(In Russ.). DOI: https://doi.org/ 10.18565/aig.2024.149
4. Klinyshkova T.V., Yakovleva A.A. Female infertility associated with genital tuberculosis. Obstetrics, Gynecology and Reproduction. 2018; 12 (1): 74-85 (In Russ.). DOI: https://doi.org/ 10.17749/2313-7347.2018.12.1.074-085
5. Leshchenko O.Ya., Malanova A.B., Atalyan A.V. Reproductive health disorders associated with genital tuberculosis in women. Obstetrics and Gynecology.2018;6:107-12.(In Russ). DOI: https://doi.org/ 10.18565/aig.2018.6.107-112
6. Efared B., Sidibé I. S., Erregad F., Hammas N., Chbani L., El Fatemi H. Female genital tuberculosis: a clinicopathological report of 13 cases. Journal of surgical case reports, 2019(3), rjz083. DOI: https://doi.org/ 10.1093/jscr/rjz083
7. Kayukova S. I. Tuberculosis of female genital organs – difficulties in diagnosing a rare form of extrapulmonary tuberculosis. Modern problems of science and education, 2012; (1): 43-43.(In Russ).
8. Djuwantono T., Permadi W., Septiani L., Faried A., Halim D., Parwati I. Female genital tuberculosis and infertility: serial cases report in Bandung, Indonesia and literature review. BMC research notes, 2017;10: 1-7. DOI: https://doi.org/ 10.1186/s13104-017-3057-z.
9. Grace G. A., Devaleenal D. B., Natrajan M. Genital tuberculosis in females. Indian Journal of Medical Research, 2017;145(4): 425-436. DOI: https://doi.org/ 10.4103/ijmr.IJMR_1550_15
10. Kulchavenya E.V. Tuberculosis and other urogenital infections as sexually transmitted diseases. Bulletin of Urology. 2023;11(1):177-183 (In Russ).DOI: https://doi.org/ 10.21886/2308-6424-2023-11-1-177-183
11. World Health Organization. Global tuberculosis report 2021: supplementary material. World Health Organization.2022: 57 р.
12. Tzelios C., Neuhausser W. M., Ryley D., Vo N., Hurtado R. M., Nathavitharana R. R. Female genital tuberculosis. Open Forum Infect Dis, 2022;9(11):ofac543. DOI: https://doi.org/ 10.1093/ofid/ofac543
13. Sethi S., Dhaliwal L., Dey P., Kaur H.,Yadav R. Loop-mediated isothermal amplification assay for detection of Mycobacterium tuberculosis complex in infertile women. Indian journal of medical microbiology,2016; 34(3): 322-327. DOI: https://doi.org/ 10.4103/0255-0857.188323.
14. Kashyap B., Srivastava N., Kaur I. R., Jhamb R., Singh, D. K. Diagnostic dilemma in female genital tuberculosis-staining techniques revisited. Iranian journal of reproductive medicine, 2013;11(7): 545.
15. Shevchenko S. Yu., Alekseeva T. V., Baranchukova A. A. Informativeness of Diaskintest in screening of urogenital tuberculosis. Siberian Medical Bulletin, 2017;(1): 42-44.(In Russ).
16. Gilyazutdinova Z.Sh. Genital tuberculosis in women (practical guide). Kazan: "Dom Pechati", 1998-102 p.
17. Lu X., Li C., Li W., Long X., Fang Y., Sun R., Xie Y. Use of Interferon‐γ release assay for the diagnosis of female genital tuberculosis in Northwest China. Journal of Clinical Laboratory Analysis, 2019;33(1): e22621. DOI: https://doi.org/ 10.1002/jcla.22621
18. Shah H.U., Sannananja B., Baheti A.D., Udare A.S., Badhe P.V. Hysterosalpingography and ultrasonography findings of female genital tuberculosis. Diagnostic and Interventional Radiology, 2015; 21(1): 10. DOI: https://doi.org/ 10.5152/dir.2014.13517
19. Aggarwal A., Das C.J., Manchanda S. Imaging spectrum of female genital tuberculosis: a comprehensive review. Current Problems in Diagnostic Radiology, 2022;51(4): 617-627. DOI: https://doi.org/ 10.1067/j.cpradiol.2021.06.014
20. Klein T.A., Richmond J.A., Mishell Jr. D.R. Pelvic tuberculosis. Obstetrics and Gynecology, 1976;48(1): 99-104.
21. Sharma J.B. Sharma's parachute sign a new laparoscopic sign in abdomino pelvic tuberculosis. Indian Journal of Tuberculosis, 2021;68(3): 389-395. DOI: 10.1016/j.ijtb.2019.06.004
Review
For citations:
Andrianov M.A., Davletova A.K., Kurmanbaev T.E., Albegova L.E., Nurmukhametova E.T. Difficulties in diagnostics of genital tuberculosis. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2025;15(3):201-206. (In Russ.) https://doi.org/10.20340/vmi-rvz.2025.3.CASE.3