Синдром обратимой задней энцефалопатии (обзор литературы)

Синдром обратимой задней энцефалопатии (СОЗЭ, Posterior Reversible Encephalopathy Syndrome (PRES)) – клиникорадиологический синдром, характеризующийся острой церебральной эндотелиопатией, нарушением проницаемости гематоэнцефалического барьера с формированием вазогенного отёка белого вещества головного мозга, преимущественно затылочной и теменной долей и, как следствие, развитием таких клинических проявлений, как головная боль, снижение уровня бодрствования, эпилептические приступы и зрительные расстройства. Изначально данное заболевание связывали только с артериальной гипертензией, однако в последствии исследования показали, что синдром обратимой задней энцефалопатии может быть вызван и другими факторами, такими как инфекции, болезни почек или использование определённых лекарственных препаратов. В данной статье рассмотрены основные причины возникновения синдрома обратимой задней энцефалопатии, клинические проявления и методы верификации, а также принципы лечения данного состояния.

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