Changes in the morphofunctional state of the adrenal glands in cancer (literature review)

Oncopathology is one of the main causes of mortality and makes diagnosis difficult due to the asymptomatic course of metastases and non-specificity of analyses. Tumours act as stressors, causing metabolic disorders and altering metabolic regulation. The adrenal glands respond to stressors and their changes, especially in the fascicular and reticular zones, may indicate long-term tumour exposure. However, the literature is insufficient to highlight the impact of various benign and malignant tumours on the morphofunctional state of the adrenal glands. The studied patterns of changes in the morphofunctional state of the adrenal glands in various malignant tumors of the abdominal organs can be used to predict the course of oncopathology, assess the effect of concomitant pathology on the course of the disease and the effectiveness of treatment on the outcome. The revealed age and sex characteristics of changes in the morphofunctional state of the adrenal glands in various malignant tumors of the abdominal organs can be used as the basis for methods of preventing deaths.

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