Anaphylaxis in obstetrics: a literature review and own clinical observation

Background. Anaphylactic shock in obstetrics is a rare but potentially life-threatening cause of maternal and perinatal morbidity and mortality, largely determined by the specific immunological alterations occurring during pregnancy.
Case presentation. We report a case of anaphylactic shock developing after administration of cefotaxime as preoperative antibiotic prophylaxis, resulting in a fatal maternal outcome. The causative agent was a cephalosporin capable of inducing cross-allergic reactions with penicillins.
Conclusion. Thorough allergological history-taking and careful assessment of comorbidities in pregnant patients may not entirely prevent anaphylaxis, but can substantially reduce its severity and consequences.

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