BIOCHEMICAL PARAMETERS OF THE INTENSITY OF SYSTEMIC INFLAMMATORY RESPONSE IN THE ASSESSMENT OF BIOCOMPATIBILITY OF POLYCAPROLACTONE/VATERITE SCAFFOLDS
Abstract
In this study, we analyzed biocompatibility of polycaprolactone/vaterite scaffolds by assessing the dynamics of systemic inflammatory response. We detected an increase in the CRP level after 7 days and no changes in the level TNF-α and IL-1β after 7 and 21 days, which indicates a weak and short-term inflammatory reaction and is a pathogenetic component of matrix biocompatibility.
About the Authors
E. A. Galashina
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Россия
Saratov
Россия
Saratov
Yu. A. Chibrikova
Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian Federation
Россия
Saratov
Россия
Saratov
A. N. Ivanov
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Россия
Saratov
Россия
Saratov
E. V. Gladkova
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Россия
Saratov
Россия
Saratov
I. A. Norkin
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Россия
Saratov
Россия
Saratov
References
1. Kotlyarova M.S. i dr. Biorezorbiruemye skaffoldy na osnove fibroina dlya regeneracii kostnoj tka-ni // Vestnik Moskovskogo universiteta. Seriya Biologiya. – 2017. – № 72 (4). – S. 222–228.
2. Dolgalev A.A., Arakelyan N.G. Tkanevaya inzheneriya pri vosstanovlenii defektov kostnoj tkani // Vestnik molodogo uchyonogo. – 2018. – № 4. – S. 19–24.
3. Wang W., Huang B., Byun J.J. et al. Assessment of PCL/carbon material scaffolds for bone regeneration // Journal of the Mechanical Behavior of Biomedical Materials. – 2019. – No 93. – Р. 52–60.
4. Schröder R., Besch L., Pohlit H. et al. Particles of vaterite, a metastable CaCO3 polymorph, exhibit high biocompat-ibility for human osteoblasts and endothelial cells and may serve as a biomaterial for rapid bone regeneration // Journal of Tissue Engineering and Regenerative Medicine. – 2018. – No 12 (7). – Р. 1754-68.
5. Novochadov V.V. Problema upravleniya kletochnym zaseleniem i remodelirovaniem tkaneinzhenernyh matric dlya vosstanovleniya sustavnogo hryashcha // Vestnik Volgograd. gos. un-ta. Ser. 11, Estestv. nauki. – 2013. – № 1 (5). – S. 19–28.
6. Vishwakarma A., Bhise N.S., Evangelista M.B. et al. Engineering immunomodulatory biomaterials to tune the in-flammatory response // Trends in Biotechnology. – 2016. – № 34 (6). – Р. 470-82.
7. Prudente A., Favaro W., Filho P. et al. Host Inflammatory Response to Polypropylene Implants: Insights From a Quantitative Immunohistochemical and Birefringence Analysis in a Rat Subcutaneous Model // International Brazilian Journal of Urology. – 2016. – No 42 (3). – Р. 585-93.
8. Chereshnev V.A., Gusev E.Yu. Immunologicheskie i patofiziologicheskie mekhanizmy sistemnogo vospale-niya // Medicinskaya immunologiya. – 2012. – № 14 (1-2). – S. 9--20.
9. Vasconcelos D.M., Gonçalves R.M., Almeida C.R. et al. Fibrinogen scaffolds with immunodulatory properties promote in vivo bone regeneration // Biomaterials. – 2016. – No 111. – Р. 163–178.
10. Haase T., Krost A., Sauter T. et al. In Vivo Biocompatibility Assessment of Poly (Ether Imide) Electrospun Scaffolds // Journal of Tissue Engineering and Regenerative Medicine. – 2017. – No 11(4). – Р. 1034–44.
Review
For citations:
Galashina E.A., Chibrikova Yu.A., Ivanov A.N., Gladkova E.V., Norkin I.A. BIOCHEMICAL PARAMETERS OF THE INTENSITY OF SYSTEMIC INFLAMMATORY RESPONSE IN THE ASSESSMENT OF BIOCOMPATIBILITY OF POLYCAPROLACTONE/VATERITE SCAFFOLDS. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(2):98-103. (In Russ.)
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