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BIOCHEMICAL PARAMETERS OF THE INTENSITY OF SYSTEMIC INFLAMMATORY RESPONSE IN THE ASSESSMENT OF BIOCOMPATIBILITY OF POLYCAPROLACTONE/VATERITE SCAFFOLDS

Abstract

In this study, we analyzed biocompatibility of polycaprolactone/vaterite scaffolds by assessing the dynamics of systemic inflammatory response. We detected an increase in the CRP level after 7 days and no changes in the level TNF-α and IL-1β after 7 and 21 days, which indicates a weak and short-term inflammatory reaction and is a pathogenetic component of matrix biocompatibility.

About the Authors

E. A. Galashina
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Russian Federation
Saratov


Yu. A. Chibrikova
Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Saratov


A. N. Ivanov
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Russian Federation
Saratov


E. V. Gladkova
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Russian Federation
Saratov


I. A. Norkin
Research Institute of Traumatology, Orthopedics, and Neurosurgery, Federal State Budgetary Institution of Higher Education ‘V.I. Razumovsky Saratov State Medical University,’ Ministry of Health of the Russian Federation
Russian Federation
Saratov


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Review

For citations:


Galashina E.A., Chibrikova Yu.A., Ivanov A.N., Gladkova E.V., Norkin I.A. BIOCHEMICAL PARAMETERS OF THE INTENSITY OF SYSTEMIC INFLAMMATORY RESPONSE IN THE ASSESSMENT OF BIOCOMPATIBILITY OF POLYCAPROLACTONE/VATERITE SCAFFOLDS. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(2):98-103. (In Russ.)

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ISSN 2226-762X (Print)
ISSN 2782-1579 (Online)