Toxicological characteristics of dental gel ‘Matripin’
Abstract
We performed toxicological evaluation of dental gel ‘Matripin.’ Objective: to assess acute and chronic toxicity of dental gel ‘Matripin’ on mature rats. Animals were kept in standard vivarium conditions. Our findings suggest that ‘Matripin’ is a class 5 drug (virtually non-toxic substance). The assessment of chronic toxicity demonstrated that topical application of ‘Matripin’ does not have any toxic effects on the lungs, heart, spleen, liver, and kidneys, since morphological changes in these organs were similar in the experimental and control groups.
About the Authors
L. I. Arystan
International Research and Manufacturing Holding ‘Phytochemistry
Kazakhstan
Karaganda
Kazakhstan
Karaganda
M. A. Romanova
International Research and Manufacturing Holding ‘Phytochemistry
Kazakhstan
Karaganda
Competing Interests:
Kazakhstan
Karaganda
Competing Interests:
Романова Мария Андреевна, магистр естественных наук, младший научный сотрудник
Караганда
D. Dzh. Kauzbaeva
Karaganda Medical University
Kazakhstan
Karaganda
Kazakhstan
Karaganda
S. T. Tuleutaeva
Karaganda Medical University
Kazakhstan
Karaganda
Kazakhstan
Karaganda
D. S. Tutay
International Research and Manufacturing Holding ‘Phytochemistry
Kazakhstan
Karaganda
Kazakhstan
Karaganda
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Review
For citations:
Arystan L.I., Romanova M.A., Kauzbaeva D.D., Tuleutaeva S.T., Tutay D.S. Toxicological characteristics of dental gel ‘Matripin’. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(1):5-16. (In Russ.)
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