GENERAL ISSUES OF IRON METABOLISM AND PATHOGENESIS OF IRON DEFICIENCY ANEMIA
Abstract
Iron is an essential trace element, because it is required for adequate erythropoietic function, oxidative metabolism, and cellular immune responses. In this article, we analyze the mechanisms of iron homeostasis and pathogenesis of iron-deficiency conditions and iron-deficiency anemia.
About the Authors
T. E. Potemina
Federal State Budgetary Institution of Higher Education ‘Volga Region Research Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Nizhny Novgorod
Russian Federation
Nizhny Novgorod
C. A. Volkova
Federal State Budgetary Institution of Higher Education ‘Volga Region Research Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Nizhny Novgorod
Russian Federation
Nizhny Novgorod
S. V. Kuznetsova
Federal State Budgetary Institution of Higher Education ‘Volga Region Research Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Nizhny Novgorod
Russian Federation
Nizhny Novgorod
A. V. Pereshein
Federal State Budgetary Institution of Higher Education ‘Volga Region Research Medical University’, Ministry of Health of the Russian Federation
Russian Federation
Nizhny Novgorod
Russian Federation
Nizhny Novgorod
References
1. Andreichev N.A., Baleeva L.V. Zhelezodeficitnye sostoyaniya i zhelezodeficitnaya anemiya // Vest-nik sovremennoj klinicheskoj mediciny. – 2009. – T. 2. – № 3. – S. 60–65.
2. Molekulyarnye i kletochnye osnovy metabolizma zheleza u cheloveka (obzor) / I.V. Milto, I.V. Suhodolo, V.D. Prokopeva i dr. // Biohimiya. – 2016. – T. 81. – № 6. – S. 725–742.
3. Patologicheskaya biohimiya / A.D. Taganovich, E.I. Oleckij, I.L. Kotovich. – M.: Binom, 2013. – 448 s.
4. Patofiziologiya mikroelementov. Soobshenie 3. Zhelezo / D. Oberlis, A.V. Skalnyj, M.G. Skal-naya i dr. // Patogenez. – 2016. – T.14. – № 2. – C. 20– 27.
5. Smirnov O.A., Smirnova O.N. Giposideroz kak forma mikroelementoza s narusheniem obmena zhe-leza // Mikroelementy v medicine. – 2019. – № 20 (3). – S. 12−19.
6. Strutynskij A.V. Zhelezodeficitnye anemii. Diagnostika i lechenie // Trudnyj pacient. – 2013. – № 12. – T. 11. – C. 38–42.
7. Stuklov N.I., Mitchenkova A.A. Anemiya i deficit zheleza. Globalnye problemy i algoritmy re-shenij // Terapiya. – 2018. – № 6 (24). – S. 147–156.
8. Cvetaeva N.V., Levina A.A., Mamukova Yu.I. Osnovy regulyacii obmena zheleza // Klinicheskaya onko-gematologiya. – 2010. – T. 3. – № 3. – S. 278–283.
9. Anderson Gregory J., Frazer David M. Current understanding of iron homeostasis // The American Journal of Clinical Nutrition. – 2017. – V. 106 (Suppl_6). – 1559S–1566S. DOI: 10.3945/ajcn.117.155804
10. Besarab A., Hemmerich S. Iron-Deficiency Anemia // Management of Anemia A Comprehensive Guide for Clinicians. – 2018. – P. 11–29.
11. Biomarkers of Nutrition for Development (BOND) – Iron Review / Sean Lynch, Christine M Pfeiffer, Michael K Georgieff and al. // The Journal of Nutrition. – 2018. – V. 148( suppl_1):1001S–1067S.
12. Camaschella C. How I manage patients with atypical microcytic anaemia // British Journal of Haematology. – 2012. – V. 160. – P. 12–24.
13. Camaschella C. New insights into iron deficiency and iron deficiency anemia // Blood Reviews. – 2017. – 31 (4). – P. 225–233.
14. Cappellini M.D., Musallam K.M., Taher A.T. Iron deficiency anaemia revisited // The Association for the Publication of the Journal of Internal Medicine. – 2020. – V. 287. – P. 153–170.
15. Crichton R. Iron Metabolism. From Molecular Mechanisms to Clinical Consequences. – Wiley. – 2016. – P. 556.
16. Dev S., Jodie L. Babitt Overview of Iron Metabolism in Health and Disease // Hemodial Int. – 2017. – V. 21 (Suppl 1): S6–S20. DOI:10.1111/hdi.12542
17. Gozzelino R., Arosio P. Iron Homeostasis in Health and Disease // Int. J. Mol. Sci. – 2016. – V. 17(1), 130; DOI:10.3390/ijms17010130
18. Lopez A., Cacoub P., Macdougall I.C., Peyrin-Biroulet L. Iron defi ciency anaemia // Lancet. – 2016. – V. 387. – P. 907–916.
19. Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches / K. Shubham, T. Anukiruthika, S. Dutta and al. // Trends in Food Science & Technology. – 2020. – V. 99. – P. 58–75.
20. Oliveira F., Rocha S., Fernandes R. Iron Metabolism: From Health to Disease // Journal of Clinical Laboratory Analysis. – 2014. – V. 28 – N. 3. – P. 210– 218.
21. Two to Tango Regulation of Mammalian Iron Metabolism / Matthias W. Hentze, Martina U. Muckenthaler, Bruno Galy, Clara Camaschella // Cell. – 2010. – № 142. – P. 24–38.
Review
For citations:
Potemina T.E., Volkova C.A., Kuznetsova S.V., Pereshein A.V. GENERAL ISSUES OF IRON METABOLISM AND PATHOGENESIS OF IRON DEFICIENCY ANEMIA. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2020;(3):125-137. (In Russ.)
Views:
313
Email this article 