Aggressive angiomyxoma as an incidental finding in a man during a routine check-up
https://doi.org/10.20340/vmi-rvz.2025.3.CASE.2
Abstract
Deep (aggressive) angiomyxoma is a rare benign mesenchymal tumor that usually arises from the soft tissues of the perineum and pelvis in premenopausal women. As of September 2020, only 88 cases of aggressive angiomyxoma in men have been reported. Deep or aggressive angiomyxoma is usually asymptomatic. At the same time, it is characterized by slow growth, a tendency to deeply invade the tissues of the retroperitoneal space and the muscles of the pelvic diaphragm. The article discusses a clinical case of deep angiomyxoma detection in a man during a medical examination. The importance of conducting a thorough differential diagnosis, regular preventive examinations and medical examinations by patients, as well as the significance of an objective physical examination of the patient at each visit to the doctor for the earliest possible detection of signs of neoplasms is shown.
About the Authors
E. A. BykhanovaRussian Federation
Elena A. Bykhanova - Resident of the Department of Hospital Therapy and Immunology with the course of professional development; General Practitioner of Polyclinic No. 2
Author's contribution: author of the idea, writing the working version of the manuscript, responsibility for the integrity of all parts of the article.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022;
43, Karl Marx St., Krasnoyarsk, 660049
Competing Interests:
The authors declare no competing interests.
T. A. Garkusha
Russian Federation
Tat'yana A. Garkusha - Assistant of the Department of Pathological Anatomy named after Professor P.G. Podzolkov; pathologist
Author's contribution: author of the idea, writing the working version of the manuscript, preparing illustrations.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022;
3D, Partizana Zheleznyaka str., Krasnoyarsk, 660022
Competing Interests:
The authors declare no competing interests.
M. N. Kuznetsov
Russian Federation
Mikhail N. Kuznetsov - Cand. Sci. (Med.), Associate Professor of the Department of General Surgery named after prof. M.I. Gulman; Head of the Surgical Department No. 2
Author's contribution: author of the idea, writing the working version of the manuscript, preparing illustrations.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022;
47, Lomonosov st., Krasnoyarsk, 660058
Competing Interests:
The authors declare no competing interests.
I. V. Demko
Russian Federation
Irina V. Demko - Dr. Sci. (Med.), Professor, Head of the Department of Hospital Therapy and Immunology with a Course in Postgraduate Education; Head of the Pulmonary Allergology Center, Krasnoyarsk Regional Clinical Hospital No. 2.
Author's contribution: scientific consultant, editing the text of the article.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022
Competing Interests:
The authors declare no competing interests.
N. I. Kondrashova
Russian Federation
Natal'ya Ivanovna Kondrashova - Head of Polyclinic No. 2
Author's contribution: collection and processing of material, editing the text of the article.
43, Karl Marx St., Krasnoyarsk, 660049
Competing Interests:
The authors declare no competing interests.
O. T. Oleynikova
Russian Federation
Ol'ga T. Oleynikova - Head of the Therapy Department No. 2 of the Polyclinic No. 2
Author's contribution: collection and processing of material, editing of the article text.
43, Karl Marx St., Krasnoyarsk, 660049
Competing Interests:
The authors declare no competing interests.
E. S. Khramikhina
Russian Federation
Elizaveta S. Khramikhina - Student of the Faculty of Medicine
Author's contribution: collection and processing of material, literature analysis.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022
Competing Interests:
The authors declare no competing interests.
I. S. Krasnoramenskaya
Russian Federation
Irina S. Krasnoramenskaya - Therapist of Polyclinic No. 2
Author's contribution: collection and processing of material, literature analysis, preparation of illustrations.
43, Karl Marx St., Krasnoyarsk, 660049
Competing Interests:
The authors declare no competing interests.
V. V. Deulina
Russian Federation
Vera V. Deulina - Cand. Sci. (Med.), Associate Professor of the Department of General Surgery named after prof. M.I. Gulman
Author's contribution: collection and processing of material, literature analysis.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022
Competing Interests:
The authors declare no competing interests.
N. S. Shtoppel'
Russian Federation
Nataliya S. Shtoppel' - Cand. Sci. (Med.), Associate Professor of the Department of General Surgery named after prof. M.I. Gulman
Author's contribution: collection and processing of material, literature analysis.
1, Partizana Zheleznyaka str., Krasnoyarsk, 660022
Competing Interests:
The authors declare no competing interests.
A. E. Khardikova
Russian Federation
Aleksandra E. Khardikova - Proctologist of the surgical department No. 2
Author's contribution: collection and processing of material, literature analysis, preparation of illustrations.
47, Lomonosov st., Krasnoyarsk, 660058
Competing Interests:
The authors declare no competing interests.
References
1. Dellino, M, Magazzino F, Domenici L, Cicogna S, Miano ST, Pignata S. et al. Aggressive Angiomyxoma of the Lower Female Genital Tract: A Review of the MITO Rare Tumors Group. Cancers. 2024;16(7):1375. https://doi.org/10.3390/cancers16071375
2. Blandamura S, Cruz J, Faure Vergara L, Machado Puerto I, Ninfo V. Aggressive angiomyxoma: a second case of metastasis with patient's death. Human Pathology. 2003; 34(10):1072-1074. https://doi.org/10.1053/s0046-8177(03)00419-2
3. Geng J, Cao B, Wang L. Aggressive angiomyxoma: an unusual presentation. Korean Journal Radiology. 2012;13(1): 90-93. https://doi.org/10.3348/kjr.2012.13.1.90
4. Siassi RM, Papadopoulos T, Matzel KE. Metastasizing aggressive angiomyxoma. The New England Journal of Medicine. 1999; 341(23):1772. https://doi.org/10.1056/nejm199912023412315
5. Steeper, T. A, Rosai, J. Aggressive angiomyxoma of the female pelvis and perineum. The American Journal of Surgical Pathology. 1983;7:463–476. https://doi.org/10.1097/00000478-198307000-00009
6. Chatzigrigoriadis C, Tatanis V, Spinos T, Peteinaris A, Samaras A, Thanos A et al. An Unusual Cause of Inguinal Mass in a Patient with Urolithiasis: A Case Report of Deep (Aggressive) Angiomyxoma in a Male Patient. Clinical Practice. 2024; 14: 2705–2712. https://doi.org/10.3390/ clinpract14060213
7. Sabbagh AJ, Arnaout K, Arnaout AY, Toutounji B, Ghabreau L, Ayoub Ket al. Aggressive angiomayxoma in men: Case report and systematic review. Annals of medicine and surgery. 2022;79:103880. https://doi.org/10.1016/j.amsu.2022.103880
8. Cao Z, Miao L, Liu M, Liu W, Zhang H, Liu X et al. Aggressive angiomyxoma: The first case report in skull. Frontiers in Surgery. 2022;9: 985739, https://doi.org/10.3389/fsurg.2022.985739
9. Aisihaer M, TuoLiKen H, Muhetaer M, Song G. Aggressive angiomyxoma of transplanted kidney in male: A case report and brief review of literature. Urology Case Reports. 2024;55:102796, https://doi.org/10.1016/j.eucr.2024.102796
10. Rawlinson NJ, West WW, Nelson M, Bridge JA. Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: report of a case and review of the literature. Cancer Genetics and Cytogenetics. 2008;181(2):119-24. https://doi.org/10.1016/j.cancergencyto.2007.11.008.
11. Cicogna S, Dellino M, Miano ST, Magazzino F, Domenici L, Pignata S et al. Aggressive Angiomyxoma of the Lower Female Genital Tract in Pregnancy: A Review of the MITO Rare Tumors Group. Cancers. 2023;15(13):3403. https://doi.org/10.3390/cancers15133403
12. Idrees MT, Hoch BL, Wang BY, Unger PD. Aggressive angiomyxoma of male genital region. Report of 4 cases with immunohistochemical evaluation including hormone receptor status. Annals of Diagnostic Pathology. 2006;10(4):197-204. https://doi.org/10.1016/j.anndiagpath.2005.09.002
13. Angelico G, Marletta S, Broggi G, Vigneri P, Vecchio GM, Salvatorelli L et al. Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview. Diagnostics. 2022;12(2):357. https://doi.org/10.3390/diagnostics12020357
14. Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL et al. Fibroblasts: Origins, definitions, and functions in health and disease. Cell. 2021;184(15):3852-3872. https://doi.org/10.1016/j.cell.2021.06.024
15. Carlinfante G, De Marco L, Mori M, Ferretti S, Crafa P. Aggressive angiomyxoma of the spermatic cord. Two unusual cases occurring in childhood. Pathology Research and Practice. 2001;197(2):139-44. https://doi.org/10.1078/0344-0338-00025. PMID: 11261819.
16. Ywasa Y., Fletcher C., Flucke U. WHO Classification of Soft Tissue and Bone Tumours. WHO; Geneva, Switzerland: 2020.
17. Lai CH, Ji J, Bian X, Xu T, Hu H. Prostatic aggressive angiomyxoma (AAM) with initial presentation of urinary obstruction: a rare case report and literature review. Translational Andrology and Urology. 2024;13(12):2827-2832. https://doi.org/10.21037/tau-24-425.
18. Hajjar R, Alharthi M, Richard C, Gougeon F, Loungnarath R. Pelvic Aggressive Angiomyxoma: Major Challenges in Diagnosis and Treatment. Cureus. 2019;11(4):e4419. https://doi.org/10.7759/cureus.4419
Supplementary files
Review
For citations:
Bykhanova E.A., Garkusha T.A., Kuznetsov M.N., Demko I.V., Kondrashova N.I., Oleynikova O.T., Khramikhina E.S., Krasnoramenskaya I.S., Deulina V.V., Shtoppel' N.S., Khardikova A.E. Aggressive angiomyxoma as an incidental finding in a man during a routine check-up. Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH). 2025;15(3):194-200. (In Russ.) https://doi.org/10.20340/vmi-rvz.2025.3.CASE.2