Несостоятельности трансплантата у реципиентов аллогенных гемопоэтических стволовых клеток: диагностика и лечение

Несостоятельность трансплантата – группа осложнений после трансплантации аллогенных гемопоэтических стволовых клеток, которая встречается по разным данным до 30 % случаев. В группу осложнений входят первичная и вторичная несостоятельность трансплантата, первичная, вторичная и транзиторная гипофункция трансплантата и отторжение трансплантата. Сложности диагностики заключаются в отсутствии единых критериев, принятых в трансплантационном сообществе, и в двоякой интерпретации этих осложнений по данным иностранной литературы. Целью данного обзора литературы было определить наиболее часто встречающиеся критерии различных видов несостоятельности трансплантата и тактику диагностики и лечения. В обзоре мы проанализировали данные различных источников литературы, дали определения несостоятельности и гипофункции трансплантата, проанализировали литературные данные по применяемым методам лечения данных состояний.

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